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John E Starrett Jr, Muzammil M Mansuri, John C Martin, David R Tortolani, Joanne J Bronson: Prodrugs of phosphonates. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, September 2, 1997: US05663159 (97 worldwide citation)

There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


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John E Starrett Jr, Muzammil M Mansuri, John C Martin, David R Tortolani, Joanne J Bronson: Prodrugs of phosphonates. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, August 11, 1998: US05792756 (76 worldwide citation)

There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


3
Muzammil M Mansuri, John C Martin, Thomas W Hudyma, Joanne J Bronson, Louis M Ferrara: Phosphonomethoxy carbocyclic nucleosides and nucleotides. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Mark L Bosse, April 28, 1998: US05744600 (28 worldwide citation)

A compound of the Formula I or Formula II ##STR1## wherein R.sup.1 and R.sup.2 are independently hydrogen, hydroxy, chlorine, fluorine, bromine, or an organic substituent having 1 to 5 carbon atoms and selected from acyloxy having a hydrocarbon stem of 1 to 4 carbon atoms, alkoxy, alkylthio, amino, ...


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Michael F Parker, Katharin E McElhone, Robert A Mate, Joanne J Bronson, Yonghua Gai, Carl P Bergstrom, Lawrence R Marcin, John E Macor: α-(N-sulfonamido)acetamide derivatives as β-amyloid inhibitors. Bristol Myers Squibb Company, Aldo A Algieri, November 27, 2007: US07300936 (21 worldwide citation)

There is provided a series of novel α-(N-sulfonamido)acetamide compounds of the Formula (I) wherein R, R1, R2 and R3 are defined herein, which are inhibitors of β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by anti-amyloid ac ...


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Robert W Webb II, Joanne J Bronson, John C Martin: Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, July 22, 1997: US05650510 (16 worldwide citation)

A series of compounds of Formula I which have anti-tumor activity, and are useful in treating viral infections, their compositions and use. ##STR1## In Formula I B is a purine or pyrimidine base; alk.sub.1 alk.sub.2 and alk.sub.3 are chemical bonds or alkylene groups; Q is hydrogen or hydroxyl; and ...


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Robert W Webb II, Joanne J Bronson, John C Martin: Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, December 29, 1998: US05854228 (14 worldwide citation)

A series of compounds of Formula I which have anti-tumor activity, and are useful in treating viral infections, their compositions and use. ##STR1## In Formula I B is a purine or pyrimidine base; alk.sub.1 alk.sub.2 and alk.sub.3 are chemical bonds or alkylene groups; Q is hydrogen or hydroxyl; and ...


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Kuo Long Yu, Joanne J Bronson, John C Martin: Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, April 12, 1994: US05302585 (12 worldwide citation)

The present invention provides chiral nucleotide analogs having the Formulas I and II ##STR1## and pharmaceutically acceptable salts and solvates thereof, and their pharmaceutical compositions for use in the treatment of viral infections, especially those caused by human immunodeficiency virus (HIV) ...


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Joanne J Bronson, Stanley V D Andrea, Shelley E Hoeft, John D Matiskella, Peter F Misco Jr, Bing Y Luh, Dane M Springer, Yasutsugu Ueda, John A Wichtowski: Cephalosporin derviatives. Bristol Myers Squibb Company, David M Morse, April 15, 1997: US05620969 (11 worldwide citation)

Novel cephem derivatives represented by the general formula ##STR1## in which the Acyl substituent is a group of the formula ##STR2## wherein Ar is a lipophilic optionally substituted phenyl, naphthyl or pyridyl group; R.sup.1 represents either the residue of a heterocyclic amino acid or a C.sub.2 - ...


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John D Matiskella, Stanley V D Andrea, Thomas W Hudyma, Yasutsugu Ueda, Oak K Kim, Raymond F Miller, Shelley E Hoeft, Joanne J Bronson: Cephalosporin derivatives. Bristol Meyers Squibb Company, David N Morse, July 25, 2000: US06093712 (10 worldwide citation)

Provided are cephem derivatives represented by the general formula ##STR1## wherein Ar, R.sup.1, R.sup.2, R.sup.3, R.sup.9 and R.sup.10 are as defined in the application. The derivatives are gram-positive antibacterial agents especially useful in the treatment of diseases caused by methicillin-resis ...


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