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Nalin Subasinghe, Ehab Khalil, Kristi A Leonard, Farah Ali, Heather Hufnagel, Jeremy M Travins, Shelley K Ballentine, Kenneth T Wilson, Maxwell D Cummings, Wenxi Pan, Joan Gushue, Sanath Meegalla, Mark Wall, Jinsheng Chen, Jonathan M Rudolph, Hui Huang: Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions. 3 Dimensional Pharmaceuticals, November 21, 2006: US07138530 (11 worldwide citation)

Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmac ...


2
Nalin Subasinghe, Ehab Khalil, Kristi Leonard, Farah Ali, Heather Rae Hufnagel, Jeremy M Travins, Shelley K Ballentine, Kenneth T Wilson, Maxwell D Cummings, Wenxi Pan, Joan Gushue, Sanath Meegalla, Mark Wall, Jinsheng Chen, M Jonathan Rudolph, Hui Huang: Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions. 3 Dimensional Pharmaceuticals, September 19, 2006: US07109354 (6 worldwide citation)

Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I or a solvate, hydrate or pharmaceu ...


3
Tianbao Lu, Karen L Milkiewicz, Pierre Raboisson, Maxwell David Cummings, Raul R Calvo, Daniel J Parks, Louis V Lafrance III, Juan Jose Marugan Sanchez, Joan Gushue, Kristi Leonard: Substituted 1,4-diazepines and uses thereof. Ortho McNeil Pharmaceutical, Laura Donnelly, October 3, 2006: US07115598 (2 worldwide citation)

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: R1, R2, R9, R10, Ra, Rd and M are defined ...


4
Tianbao Lu, Karen L Milkiewicz, Pierre Raboisson, Maxwell David Cummings, Raul R Calvo, Daniel J Parks, Louis V Lafrance, Juan Jose Marugan Sanchez, Joan Gushue, Kristi Leonard: Substituted 1,4-diazepines and uses thereof. Philip S Johnson, Johnson & Johnson, November 4, 2004: US20040220179-A1

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: 1 or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: R1, R2, R9, R10, Ra, Rd and M are define ...


5
Tianbao Lu, Karen L Milkiewicz, Pierre Raboisson, Maxwell David Cummings, Raul R Calvo, Daniel J Parks, Louis V LaFrance, Juan Jose Marugan Sanchez, Joan Gushue, Kristi Leonard: Substituted 1,4-diazepines and uses thereof. Philip S Johnson, Johnson & Johnson, October 19, 2006: US20060235007-A1

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: R1, R2, R9, R10, Ra, Rd and M are defined h ...


6
Nalin Subasinghe, Ehab Khalil, Kristi Leonard, Farah Ali, Heather Rae Hufnagel, Jeremy M Travins, Shelley K Ballentine, Kenneth T Wilson, Maxwell D Cummings, Wenxi Pan, Joan Gushue, Sanath Meegalla, Mark Wall, Jinsheng Chen, M Jonathan Rudolph, Hui Huang: Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions. 3 Dimensional Pharmaceuticals, Sterne Kessler Goldstein & Fox Pllc, January 15, 2004: US20040009995-A1

Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I 1 or a solvate, hydrate or pharmac ...


7
Nalin Subasinghe, Ehab Khalil, Kristi A Leonard, Farah Ali, Heather Hufnagel, Jeremy M Travins, Shelley K Ballentine, Kenneth T Wilson, Maxwell D Cummings, Wenxi Pan, Joan Gushue, Sanath Meegalla, Mark Wall, Jinsheng Chen: Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions. Philip S Johnson, Johnson & Johnson, October 20, 2005: US20050234081-A1

Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmac ...


8