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Andreas G Weichert
Jan Robert Schwark, Joachim Brendel, Heinz Werner Kleemann, Hans Jochen Lang, Andreas Weichert, Hans Willi Jansen, Wolfgang Scholz: Phenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them. Hoechst Aktiengesellschaft, Finnegan Henderson Farabow Garrett & Dunner L, December 21, 1999: US06005010 (8 worldwide citation)

Compounds of the formula ##STR1## where T is ##STR2## and R(A), R(B), R(C), R(D), R(E), R(F), x and y have the meanings indicated in the claims, and their pharmaceutically acceptable salts are effective inhibitors of the cellular sodium-proton antiporter (Na.sup.+ /H.sup.+ exchanger). These compound ...


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Andreas G Weichert
Jan Robert Schwark, Joachim Brendel, Heinz Werner Kleemann, Hans Jochen Lang, Andreas Weichert, Udo Albus, Wolfgang Scholz: Substituted cinnamic acid guanidides, a process for their preparation, their use as medicaments or diagnostic agents and medicaments comprising them. Hoechst Aktiengesellschaft, Finnegan Henderson Farabow Garrett & Dunner L, March 16, 1999: US05883133 (5 worldwide citation)

Compounds of the formula I ##STR1## are described in which at least one of the substituents R(1), R(2), R(3), R(4) and R(5) is a nitrogen-containing heterocyclic radical. They are outstanding cardiovascular therapeutic agents. They are obtained by reaction of a compound II ##STR2## with guanidine.


4
Andreas G Weichert
Andreas Weichert, Joachim Brendel, Heinz Werner Kleemann, Hans Jochen Lang, Jan Robert Schwark, Wolfgang Scholz, Udo Albus: 4-fluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them. Aventis Pharma Deutschland, Finnegan Henderson Farabow Garrett & Dunner L, December 5, 2000: US06156800 (4 worldwide citation)

There are described benzoylguanidines of the formula I ##STR1## where R(1) is R(4)--SO.sub.m, R(5)R(6)N--SO.sub.2 --; O.sub.p --(CH.sub.2).sub.q --(CF.sub.2).sub.r --CF.sub.3 ; --SR(10), --OR(10) or --CR(10)R(11)R(12); R(2) is --(CH.sub.2).sub.u --(CF.sub.2).sub.t --CF.sub.3 ; R(3) is hydrogen or in ...


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Andreas G Weichert
Andreas Weichert, Joachim Brendel, Heinz Werner Kleemann, Hans Jochen Lang, Jan Robert Schwark, Udo Albus, Wolfgang Scholz: Ortho-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament comprising them. Hoechst Aktiengesellschaft, Finnegan Henderson Farabow Garrett & Dunner L, December 14, 1999: US06001881 (2 worldwide citation)

Benzoylguanidines of the formula I ##STR1## in which: R(1) to R(4) have the meanings given in the claims, are antiarrhythmic pharmaceuticals, having a cardioprotective component, which are also valuable for the prevention of ischemically induced damage, in particular in association with the triggeri ...


9
Andreas G Weichert
Heinz Werner Kleemann, Joachim Brendel, Jan Robert Schwark, Andreas Weichert, Hans Jochen Lang, Udo Albus, Wolfgang Scholz: Substituted benzyloxycarbonylguanidines, a process for their preparation, their use as a medicament or diagnostic, and a medicament containing them. Hoechst Aktiengesellschaft, Finnegan Henderson Farabow Garrett & Dunner L, May 19, 1998: US05753710 (2 worldwide citation)

Substituted benzyloxycarbonylguanidines, a process for their preparation, their use as a medicament or diagnostic, and a medicament containing them. There are described compounds of the formula I ##STR1## in which the substituents R(1) to R(7) and X have the meanings shown in the claims, and their p ...


10
Andreas G Weichert
Heinz Werner Kleemann, Joachim Brendel, Jan Robert Schwark, Andreas Weichert, Hans Jochen Lang, Udo Albus, Wolfgang Scholz: Sulfonylamino-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic aid, and medicament containing them. Hoechst Aktiengesellschaft, Finnegan Henderson Farabow Garrett & Dunner L, January 5, 1999: US05856344 (1 worldwide citation)

Benzoylguanidines of the formula I ##STR1## in which R(1) to R(6) have the meanings stated in the claims, are antiarrhythmic pharmaceuticals which have excellent activity and a cardioprotective component and are highly suitable for the prophylaxis of infarcts and the treatment of infarcts, and for t ...