1
Stephen Brocchini, Stephen R Hanson, Joachim B Kohn: Polymeric drug formulations. Rutgers The State University of New Jersey, Synnestvedt & Lechner, March 2, 1999: US05877224 (304 worldwide citation)

Polymeric drug formulations containing a non-releasing single-phase dispersion of a water-soluble drug in a water-insoluble tissue-compatible polymer matrix. Polymeric drug formulations are also disclosed containing a single-phase dispersion of a water-soluble drug and a water-insoluble tissue-compa ...


2
Joachim B Kohn, Chun Yu: Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide). Rutgers The State University, Lerner David Littenberg Krumholz & Mentlik, August 19, 1997: US05658995 (262 worldwide citation)

Random block copolymers having the formula: ##STR1## wherein R.sub.1 is --CH.dbd.CH-- or (--CH.sub.2 --).sub.j, in which j is zero or an integer from one to eight; R.sub.2 is selected from hydrogen, straight and branched alkyl and alkylaryl groups containing up to 18 carbon atoms and derivatives or ...


3
Samuel Zalipsky, Durgadas Bolikal, Aruna Nathan, Joachim B Kohn: Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon. Enzon, Lerner David Littenberg Krumholz & Mentlik, June 15, 1993: US05219564 (235 worldwide citation)

Copolymers of poly(alkylene oxides) and amino acids or peptide sequences are disclosed, which amino acids or peptide sequences have pendant functional groups that are capable of being conjugated with pharmaceutically active compounds for drug delivery systems and cross-linked to form polymer matrice ...


4
Joachim B Kohn, Durgadas Bolikal, George L Brode, Sylvie I Ertel, Shuiyun Guan, John E Kemnitzer: Biodegradable, anionic polymers derived from the amino acid L-tyrosine. The State University Rutgers, Synnestvedt & Lechner, September 19, 2000: US06120491 (230 worldwide citation)

A polymer with a hydrolytically labile backbone and having the structure: ##STR1## wherein R.sub.9 is an alkyl, aryl or alkylaryl group with up to 18 carbon atoms having a pendent carboxylic acid group or the benzyl ester thereof;


5
Joachim B Kohn, Durgadas Bolikal, Sanyog M Pendharkar: Radio-opaque polymer biomaterials. Rutgers The State University, Synnestvedt & Lechner, November 5, 2002: US06475477 (132 worldwide citation)

Iodinated and/or brominated derivatives of aromatic dihydroxy monomers are prepared and polymerized to form radio-opaque polymers. The monomers may also be copolymerized with other dihydroxy monomers. The iodinated and brominated aromatic dihydroxy monomers can be employed as radio-opacifying, bioco ...


6
Joachim B Kohn, Kimberly A Hooper: Synthesis of tyrosine derived diphenol monomers. Rutgers The State University, Lerner David Littenberg Krumholz & Mentlik, December 24, 1996: US05587507 (126 worldwide citation)

A method for preparing diphenol compounds, which method includes the steps of coupling a hydroxyphenyl carboxylic acid with a L-tyrosine ester in a water-miscible organic reaction solvent containing a carbodiimide capable of forming a water-soluble urea by-product, thereby forming a diphenol reactio ...


7
Howard B Levene, Christelle M Lhommeau, Joachim B Kohn: Porous polymer scaffolds for tissue engineering. Rutgers The State University, Synnestvedt & Lechner, August 15, 2000: US06103255 (117 worldwide citation)

Biodegradable and biocompatible porous scaffolds characterized by a substantially continuous polymer phase, having a highly interconnected bimodal distribution of open pore sizes with rounded large pores of about 50 to about 500 microns in diameter and rounded small pores less than 20 microns in dia ...


8
Joachim B Kohn, James J Fiordeliso: Polyarylate containing derivatives of the natural amino acid L-tyrosine. Rutgers The State University of New Jersey, Lerner David Littenberg Krumholz & Mentlik, June 1, 1993: US05216115 (81 worldwide citation)

Bioerodible polyarylates derived from biocompatible dicarboxylic acids and natural amino acid-derived diphenol starting materials. Molded articles and controlled drug delivery systems prepared from the polyarylates are also disclosed.


9
Joachim B Kohn, Satish K K Pulapura: Synthesis of amino acid-derived bioerodible polymers. Rutgers The State University of New Jersey, Lerner David Littengerg Krumholz & Mentlik, March 24, 1992: US05099060 (81 worldwide citation)

Novel amino acid-derived polycarbonates and amino acid-derived diphenol compound starting materials from which the polycarbonates are polymerized. Polymer blends of the amino acid-derived polycarbonates with polyiminocarbonates prepared from identical amino acid-derived diphenol starting materials.


10
Joachim B Kohn, Robert S Langer, Steven M Niemi, James G Fox: Biodegradable polymeric drug delivery system with adjuvant activity. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds, September 5, 1989: US04863735 (77 worldwide citation)

An antigen delivery system utilizing a biodegradable polymer with good mechanical properties in combination with a material stimulating the immune system. The material having adjuvant activity may be polymer degradation products or an adjuvant which is contained within or bound to the polymer. In on ...