1
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, March 18, 2008: US07345178 (45 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


2
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch, Thomas Salzmann, David Armistead: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, December 21, 2010: US07855289 (18 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


3
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, January 10, 2012: US08093401 (17 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


4
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch, Thomas Salzmann, David Armistead: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, January 3, 2012: US08088928 (17 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


5
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, October 25, 2011: US08044198 (13 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


6
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch, Thomas Salzmann, David Armistead: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, May 15, 2012: US08178536 (1 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


7
Joseph J Nunes, Jill Milne, Chi B Vu: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, April 24, 2012: US08163908

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


8
Jesse Smith, Jill Milne, Amy Lynch, David Carney, Andre Iffland, Olivier Boss: Mass spectrometry assays for identifying compounds that activate deacetylases. Sirtris Pharmaceuticals, James T Olesen, Jeffrey A Sutton, November 6, 2012: US08304206

Provided are methods for determining the activity of proteins that modulate the acetylation state of a protein substrate. The methods may be used for determining both acetyltransferase activity and deacetylase activity. The methods utilize mass spectrometry for determining the acetylation state of a ...


9
Michael Milburn, Jill Milne, Jean Bemis, Joseph J Nunes, Roger Xie, Karl D Normington, Chi B Vu: Fused heterocyclic compounds and their use as sirtuin modulators. Sirtris Pharmaceuticals, Ropes & Gray, August 16, 2011: US07998974

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


10
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch, Thomas Salzmann, David Armistead: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Fish & Neave Ip Group, Ropes & Gray, February 15, 2007: US20070037809-A1

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...