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Jiang Xin, Greiner Jack, Maravetz Lester L, Szucs Stephen S, Visnick Melean: Antioxidant inflammation modulators: novel derivatives of oleanolic acid. Reata Pharmaceuticals, Jiang Xin, Greiner Jack, Maravetz Lester L, Szucs Stephen S, Visnick Melean, Voges Mark H, December 3, 2009: WO/2009/146216 (34 worldwide citation)

Disclosed herein are novel oleanolic acid derivatives. Methods of preparing these compounds are also disclosed. The oleanolic acid derivatives of this invention may be used for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies invo ...


2
Anderson Eric, Bolton Gary L, Ferguson Deborah A, Jiang Xin, Kral Robert M Jr, O Brian Patrick M, Visnick Melean: Compounds including an anti-inflammatory pharmacore and methods of use. Reata Pharmaceuticals, Anderson Eric, Bolton Gary L, Ferguson Deborah A, Jiang Xin, Kral Robert M Jr, O Brian Patrick M, Visnick Melean, Voges Mark H, December 3, 2009: WO/2009/146218 (34 worldwide citation)

This invention provides novel compounds comprising the following anti-inflammatory pharmacore Formula (I): wherein X, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making t ...


3
Anderson Eric, Jiang Xin, Visnick Melean: Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17. Reata Pharmaceuticals, Anderson Eric, Jiang Xin, Visnick Melean, VOGES Mark H, October 22, 2009: WO/2009/129546 (33 worldwide citation)

This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the co ...


4
Anderson Eric, Jiang Xin, Liu Xiaofeng, Visnick Melean: Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring. Reata Pharmaceuticals, Anderson Eric, Jiang Xin, Liu Xiaofeng, Visnick Melean, VOGES Mark H, October 22, 2009: WO/2009/129545 (32 worldwide citation)

This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the co ...


5
Jiang Xin, Liu Xiaofeng, Greiner Jack, Szucs Stephen S, Visnick Melean: Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives. Reata Pharmaceuticals, Jiang Xin, Liu Xiaofeng, Greiner Jack, Szucs Stephen S, Visnick Melean, VOGES Mark H, October 22, 2009: WO/2009/129548 (31 worldwide citation)

This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula (I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the ...


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ANDERSON Eric, JIANG Xin, VISNICK Melean, BENDER Christoper F, LIU Xiaofeng: DÉRIVÉS MONOMÉTHYLE TRITERPÉNOÏDES EN C4 ET LEURS PROCÉDÉS DUTILISATION, C4-MONOMETHYL TRITERPENOID DERIVATIVES AND METHODS OF USE THEREOF. REATA PHARMACEUTICALS, ANDERSON Eric, JIANG Xin, VISNICK Melean, BENDER Christoper F, LIU Xiaofeng, VOGES Mark H, September 20, 2012: WO/2012/125488 (18 worldwide citation)

Disclosed herein are novel C4-monomethyl triterpenoid compounds and derivatives thereof, including those of the formula (I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates u ...


7
Elliott Vicki S, Swarnakar Anita, Griffin Jennifer A, Lee Ernestine A, Sprague William W, Hafalia April J A, Lee Soo Yeun, Kable Amy E, Ison Craig H, Khare Reena, Chawla Narinder K, Marquis Joseph P, Jiang Xin, Jackson Alan A, Becha Shanya D, Emerling Brooke M, Jin Pei, Wilson Amy D, Richardson Thomas W, Yang Junming, Baughn Mariah R, Gandhi Ameena R, Nguyen Danniel B, Ramkumar Jayalaxmi, Kallick Deborah A, Kearney Liam, Lu Dyung Aina M, Gietzen Kimberly J, Tribouley Catherine M, Lal Preeti G, Blake Julie J, Lu Yan, Arvizu Chandra S: Protein modification and maintenance molecules. Incyte Corporation, Elliott Vicki S, Swarnakar Anita, Griffin Jennifer A, Lee Ernestine A, Sprague William W, Hafalia April J A, Lee Soo Yeun, Kable Amy E, Ison Craig H, Khare Reena, Chawla Narinder K, Marquis Joseph P, Jiang Xin, Jackson Alan A, Becha Shanya D, Emerling Brooke M, Jin Pei, Wilson Amy D, Richardson Thomas W, Yang Junming, Baughn Mariah R, Gandhi Ameena R, Nguyen Danniel B, Ramkumar Jayalaxmi, Kallick Deborah A, Kearney Liam, Lu Dyung Aina M, Gietzen Kimberly J, Tribouley Catherine M, Lal Preeti G, Blake Julie J, Lu Yan, Arvizu Chandra S, FOLEY Washington Harbour 3000 K Street NW Suite 500 Washington DC 20007 5143, January 29, 2004: WO/2004/009797 (11 worldwide citation)

Various embodiments of the invention provide human protein modification and maintenance molecules (PMMM) and polynucleotides which identify and encode PMMM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide meth ...


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Bender Steven Lee, Casperson Gerald Fries, Hu Lowe Dana Dan, Jiang Xin, Li Gang, North Michael Aidan, Wang Jianying, Wickman Grant, Brams Peter, Huang Haichun, Devaux Brigitte, Chen Haibin, Tanamachi Dawn M, Toy Kristopher, Yang Lan, Sproul Tim W, Yamanaka Mark: Alpha 5 - beta 1 antibodies and their uses. Medarex, Pfizer, Bender Steven Lee, Casperson Gerald Fries, Hu Lowe Dana Dan, Jiang Xin, Li Gang, North Michael Aidan, Wang Jianying, Wickman Grant, Brams Peter, Huang Haichun, Devaux Brigitte, Chen Haibin, Tanamachi Dawn M, Toy Kristopher, Yang Lan, Sproul Tim W, Yamanaka Mark, BRADY James W, August 13, 2009: WO/2009/100110 (5 worldwide citation)

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells ...


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FANG YADONG, JIANG XIN, CHEN DONG, ZHANG KAI: [fr] SYSTÈME ET PROCÉDÉ DE RÉSEAU AD HOC, [de] AD-HOC-NETZWERKSYSTEM UND VERFAHREN, [en] AD-HOC NETWORK SYSTEM AND METHOD. ZTE, April 28, 2010: EP2180640-A1 (4 worldwide citation)

[en] A system and method of a self-organizing network is provided, and the system comprises: a Home NodeB (101) a Home NodeB configuration server (103), which interacts with the Home NodeB (101) and provides configuration data information and version information for the Home NodeB (101) a domestic n ...