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Donna L Romero, Matthew David Wessel, Shaughnessy Robinson, Jeremy Robert Greenwood, Karl Shawn Watts, Leah Lynn Frye, Geraldine C Harriman, Alan Franklin Corin, Craig E Masse, Mee Shelley: IRAK inhibitors and uses thereof. Nimbus Iris, Choate Hall & Stewart, Andrea C Robidoux, Thomas H McLean, April 22, 2014: US08703941 (8 worldwide citation)

The present invention provides thienopyrimidine and thienopyridine compounds, compositions thereof, and methods of using the same for the treatment of diseases mediated by IRAK enzymes. Such diseases include inflammatory and proliferative diseases.


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Donna L Romero, Shaughnessy Robinson, Matthew David Wessel, Jeremy Robert Greenwood: IRAK inhibitors and uses thereof. Nimbus Iris, Choate Hall & Stewart, Andrea L C Reid, Thomas H McLean, July 21, 2015: US09085586 (2 worldwide citation)

The present invention provides arylo-fused thienopyrimidine compounds, compositions thereof, and methods of using the same.


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Donna L Romero, Matthew David Wessel, Shaughnessy Robinson, Jeremy Robert Greenwood, Karl Shawn Watts, Leah Lynn Frye, Geraldine C Harriman, Alan Franklin Corin, Craig E Masse, Mee Shelley: IRAK inhibitors and uses thereof. NIMBUS IRIS, Dechert, Andrea L C Reid, May 17, 2016: US09340554 (1 worldwide citation)

The present invention provides 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine compounds and pharmaceutical compositions thereof as inhibitors of IRAK.


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Geraldine C Harriman, Craig E Masse, James Harwood, Sathesh Bhat, Jeremy Robert Greenwood: ACC inhibitors and uses thereof. Nimbus Apollo, Choate Hall & Stewart, Andrea L C Reid, Thomas H McLean, March 3, 2015: US08969557 (1 worldwide citation)

The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.


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Donna Romero, Craig E Masse, Shaughnessy Robinson, Jeremy Robert Greenwood, Geraldine C Harriman: IRAK inhibitors and uses thereof. Nimbus Iris, Andrea L C Reid, Dechert, December 13, 2016: US09518065

The present invention provides compounds of the general formula I: or a pharmaceutically acceptable salt thereof, wherein each variable is as defined and described herein, as inhibitors of one or more interleukin-1 receptor-associated kinases (“IRAK”).


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Wei Chen, Longcheng Wang, Shunqi Yan, David J Loury, Zhaozhong J Jia, Leah Lynn Frye, Jeremy Robert Greenwood, Mee Yoo Shelley, Gordana Babic Atallah, Riccardo Zanaletti, Maria Pia Catalani, Luca Francesco Raveglia: Inhibitors of Brutons tyrosine kinase. PHARMACYCLICS, Foley Hoag, February 28, 2017: US09580416

Disclosed herein are compounds that inhibit Bruton's tyrosine kinase (Btk) having the structure of Formula (B): Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the ...


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Geraldine C Harriman, Craig E Masse, James Harwood, Sathesh Bhat, Jeremy Robert Greenwood: ACC inhibitors and uses thereof. Gilead Apollo, Sheppard Mullins Richter & Hampton, September 27, 2016: US09453026

The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.