1
Sergei M Gryaznov, Ronald G Schultz, Jer kang Chen: Oligonucleotide N3.fwdarw.P5 phosphoramidates. Lynx Therapeutics, Stephen C Macevicz, John D Mendlein, Vincent M Powers, October 12, 1999: US05965720 (189 worldwide citation)

Modified oligonucleotides 3'-NHP(O)(O.sup.-)O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation experiments demonstrated that these compounds form m ...


2
Sergei M Gryaznov, Ronald G Schultz, Jer kang Chen: Oligonucleotide N3.fwdarw.P5 phosphoramidates: triplex DNA formation. Lynx Therapeutics, January 7, 1997: US05591607 (136 worldwide citation)

Modified oligonucleotides 3'-NHP(O)(O.sup.-)O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation experiments demonstrated that these compounds form m ...


3
Sergei M Gryaznov, Ronald G Schultz, Jer Kang Chen: Oligodeoxyribonucleotide N3 P5 phosphoramidates. Lynx Therapeutics, Stephen C Macevicz, March 10, 1998: US05726297 (135 worldwide citation)

Modified oligodeoxyribonucleotide 3'--NHP (O) (O.sup.-) O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation experiments demonstrated that these comp ...


4
Sergei M Gryaznov, Ronald G Schultz, Jer kang Chen: Oligonucleotide N3-P5 phosphoramidates: hybridization and nuclease resistance properties. Lynx Therapeutics, Gary R Fabian, John D Mendlein, November 17, 1998: US05837835 (132 worldwide citation)

Modified oligonucleotides 3'-NHP(O)(O.sup.-)O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation experiments demonstrated that these compounds form m ...


5
Sergei M Gryaznov, Ronald G Schultz, Jer kang Chen: Oligonucleotide N3-P5 phosphoramidates: hybridization and nuclease resistance properties. Lynx Therapeutics, February 4, 1997: US05599922 (129 worldwide citation)

Modified oligonucleotide 3'-NHP(O)(O.sup.-)O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation experiments demonstrated that these compounds form mo ...


6
Sergei M Gryaznov, Ronald G Schultz, Jer Kang Chen: Oligonucleotide N3.fwdarw.P5 phosphoramidates: hybridization and nuclease resistance properties. Lynx Therapeutics, May 20, 1997: US05631135 (128 worldwide citation)

Modified oligonucleotides 3'-NHP(O)(O.sup.-)O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation experiments demonstrated that these compounds form m ...


7

8
Roger A O Neill, Jer Kang Chen, Claudia Chiesa, George Fry: Multiplex polynucleotide capture methods and compositions. The Perkin Elmer Corporation, Scott R Bortner, September 26, 2000: US06124092 (61 worldwide citation)

The invention relates to methods and compositions for simultaneously generating a plurality of polynucleotide sequencing ladders or PCR amplification products. Each sequencing ladder is generated from a recoverable primer, i.e., an oligonucleotide primer comprising a recovery tag. The recovery tag m ...


9
Roger A O&apos Neill, Jer Kang Chen, Claudia Chiesa, George Fry: Multiplex polynucleotide capture methods and compositions. PE Corporation, Scott R Bortner, February 4, 2003: US06514699 (38 worldwide citation)

The invention relates to methods and compositions for simultaneously generating a plurality of polynucleotide sequencing ladders or PCR amplification products. Each sequencing ladder is generated from a recoverable primer, i.e., an oligonucleotide primer comprising a recovery tag. The recovery tag m ...


10
Steven Menchen, Barnett Rosenblum, Paul Kenney, Shoeb Khan, Zhaochun Ma, Jer Kang Chen, Joe Y Lam, Boli Huang: Unnatural polymerase substrates that can sustain enzymatic synthesis of double stranded nucleic acids from a nucleic acid template and methods of use. Life Technologies Corporation, November 15, 2011: US08058414 (20 worldwide citation)

Nucleotide analogs that can sustain the enzymatic synthesis of double-stranded nucleic acid from a nucleic template are described. The nucleotide analogs include: (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine, uracil and their analogs; (ii) a label attached to ...