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Stéphane De Lombaert
Raymond F Horvath, Jennifer Tran, Stéphane De Lombaert, Kevin J Hodgetts, Philip A Carpino, David A Griffith: Certain alkylene diamine-substituted heterocycles. Neurogen Corporation, Pfizer, Ladas & Parry, January 14, 2003: US06506762 (111 worldwide citation)

The present invention also provides a general method to whereby mono-, bi-, or tricyclic heterocycles may be modified to obtain potent antagonists at the NPY


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Stéphane De Lombaert
Rajagopal Bakthavatchalam, Charles A Blum, Harry L Brielmann, James William Darrow, Stéphane De Lombaert, Alan Hutchison, Jennifer Tran, Xiaozhang Zheng, Richard Louis Elliott, Marlys Hammond: Spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines. Pfizer, Neurogen Corporation, Ladas & Parry, May 20, 2003: US06566367 (57 worldwide citation)

Substituted spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines capable of modulating NPY5 receptor activity are provided. Such compounds may be used to modulate ligand binding to NPY5 receptors in vivo or in vitro, and are particularly useful in the treat ...


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Stéphane De Lombaert
Raymond F Horvath, Jennifer Tran, Stéphane De Lombaert, Kevin J Hodgetts, Philip A Carpino, David A Griffith: Certain alkylene diamine-substituted heterocycles. Neurogen, Pfizer, Sonia K Guterman, Lawson & Weitzen, July 11, 2006: US07074929

This invention relates to novel compounds, compositions, and methods for the treatment of physiological disorders associated with an excess of neuropeptide Y. The novel compounds encompassed by the present invention are those of the formula II, IV, V, VII–IX and XI


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Rongliang Lou, Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay J Farmer, Joel A Goldberg, Roger Hanselmann, Alia Orbin, Adegboyega K Oyelere, Joseph M Salvino, Dane M Springer, Jennifer Tran, Deping Wang, Yusheng Wu: Biaryl heterocyclic compounds and methods of making and using the same. November 29, 2005: US06969726 (18 worldwide citation)

The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.


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Rongliang Lou, Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay J Farmer, Joel A Goldberg, Roger Hanselmann, Alia Orbin, Adegboyega K Oyelere, Joseph M Salvino, Dane M Springer, Jennifer Tran, Deping Wang, Yusheng Wu: Biaryl heterocyclic compounds and methods of making and using the same. Rib X Pharmaceuticals, Ivor R Elrifi, Heidi A Erlacher, Mintz Levin Cohn Ferris Glovsky and Popeo P C, December 12, 2006: US07148219 (14 worldwide citation)

The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.


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Renata Xavier Kover, Silva Terdjanian, Jennifer Tran, Andrew Thurkauf: Benzylpiperazinyl and piperidinyl ethanone derivatives: dopamine receptor subtype specific ligands. Neurogen Corporation, Steven J Sarussi, McDonnel Boehnen Hulbert & Berghoff, July 4, 2000: US06084098 (7 worldwide citation)

Disclosed are compounds of the formula: ##STR1## or pharmaceutically acceptable addition salts thereof wherein: Y represents oxygen or sulfur; Z is nitrogen or CH;



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