1
Alexei Kochkine, Jef Fensholdt, Henrik M Pfundheller: Synthesis of [2.2.1]bicyclo nucleosides. Exiqon, Peter F Corles, Christine C O&apos Day, Edwards & Angell, October 28, 2003: US06639059 (88 worldwide citation)

A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R


2
Alexei Kochkine, Jef Fensholdt, Henrik M Pfundheller: Synthesis of [2.2.1]bicyclo nucleosides. Exiqon, Peter F Corless, Christine C O&apos Day, Edwards & Angell, May 11, 2004: US06734291 (87 worldwide citation)

A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R


3
Jef Fensholdt: Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates. Exiqon, Peter F Corless, Dianne M Rees, Edwards & Angell, March 11, 2003: US06531591 (18 worldwide citation)

Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidi ...


4
Jef Fensholdt, Jacob Thorhauge, Bjarne Nørremark: Hydroxamic acid esters and pharmaceutical use thereof. Leo Pharma, Birch Stewart Kolasch & Birch, October 11, 2011: US08034811 (7 worldwide citation)

The invention relates to compounds of general formula I wherein D, E, F, G, W, Y, R1, A, R9, X, B, R8 are as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for ...


5
Jef Fensholdt, Sophie Elisabeth Havez, Bjarne Nørremark: Cyclic hydrocarbon compounds for the treatment of diseases. LEO PHARMA, Birch Stewart Kolasch & Birch, November 8, 2016: US09487494

The invention relates to novel cyclic hydrocarbon compounds and derivatives thereof, processes for the preparation thereof, to said compounds for use as a medicament, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with ...


6
Laetitia Maud Elysa Bouerat Duvold, Jef Fensholdt, Simon Feldbaek Nielsen, Xifu Liang, Sophie Elisabeth Havez, Ellen Christina Anderson, Lene Jensen, Jens Rainer Hansen: Novel therapeutic use. Leo Pharma, Birch Stewart Kolasch & Birch, July 19, 2007: US20070167488-A1

Certain oxindole compounds have been found to be effective in experimentally induced autoimmune encephalitis and are therefore suggested for the preparation of a medicament for the prevention, treatment or amelioration of multiple sclerosis, or to delay the onset of or reduce the relapse rate in mul ...


7
Alexei Kochkine, Jef Fensholdt, Henrik M Pfundheller: Synthesis of [2.2.1]bicyclo nucleosides. Exiqon, Edwards & Angell, May 15, 2003: US20030092905-A1

A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R4 and R5 are, for instance, sulfonates and R7 is, for instance, a halogen or an acetate. From compounds of the general formula II, such ...


8
Jef Fensholdt, Jacob Thorhauge, Bjarne Norremark: Novel Hydroxamic Acid Esters and Pharmaceutical Use Thereof. Leo Pharma, Birch Stewart Kolasch & Birch, October 18, 2007: US20070244117-A1

The invention relates to compounds of general formula I wherein D, E, F, G, W, Y, R1, A, R9, X, B, R8 are as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for ...


9
Xifu Liang, Thomas Høyer, Jef Fensholdt, Sophie Elisabeth Havez, Bjarne Nørremark: Substituted acetylenic compounds useful for the treatment of diseases. Leo Pharma, Birch Stewart Kolasch & Birch, November 4, 2010: US20100279936-A1

The invention relates to novel compounds according to formula Ia and Ib; (Formula Ia and Ib) wherein A represents substituted or unsubstituted C1-10heteroaryl, C6-14aryl or C6-10heterocycloalkylaryl; R1 is C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6hydroxyalkyl, C1-6haloalkyl, C1-6amino, C3-6 cycloalk ...


10
Lene Jensen, Jef Fensholdt: Src family kinase inhibitors. Birch Stewart Kolasch & Birch, April 22, 2010: US20100099710-A1

The invention relates to compounds of general formula (I) wherein X, A, R1 and R2 are as defined herein for use as antiinflammatory agents capable of modulating the activity of a protein tyrosine kinase of the Src family.