1
Kevin Rodzinak
Jeannie M Arruda, Brian T Campbell, Nicholas D P Cosford, Jacob M Hoffman, Essa H Hu, Mark E Layton, Yiwei Li, Jun Liang, Kevin J Rodzinak, Tony Siu, Brian A Stearns, Lida R Tehrani, Mark T Bilodeau, Peter J Manley: Inhibitors of Akt activity. Merck Sharp & Dohme, Matthew A Leff, David A Muthard, March 22, 2011: US07910561 (1 worldwide citation)

The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer ...


2
Kevin Rodzinak
Jeannie M Arruda, Brian T Campbell, Nicholas DP Cosford, Jacob M Hoffman, Essa H Hu, Mark E Layton, Yiwei Li, Jun Liang, Kevin J Rodzinak, Tony Siu, Brian A Stearns, Lida R Tehrani, Mark T Bilodeau, Peter J Manley: Inhibitors of Akt Activity. Merck And Co, November 20, 2008: US20080287457-A1

The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer ...


3
John Howard Hutchinson, Thomas Jon Seiders, Bowei Wang, Jeannie M Arruda, Jeffrey Roger Roppe, Timothy Parr: Polycyclic antagonists of lysophosphatidic acid receptors. Amira Pharmaceuticals, Wilson Sonsini Goodrich & Rosati, November 15, 2011: US08058300 (8 worldwide citation)

Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating L ...


4
John Howard Hutchinson, Brian Andrew Stearns, Jill Melissa Scott, Yen Pham Truong, Jeffrey Roger Roppe, Nicholas Simon Stock, Jeannie M Arruda, Thomas Jon Seiders, Bowei Wang, Deborah Volkots: receptors, N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D. Panmira Pharmaceuticals, Wilson Sonsini Goodrich & Rosati, November 29, 2011: US08067445 (6 worldwide citation)

Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alo ...


5
John Howard Hutchinson, Thomas Jon Seiders, Bowei Wang, Jeannie M Arruda, Jeffrey Roger Roppe, Timothy Parr: Antagonists of lysophosphatidic acid receptors. Amira Pharmaceuticals, Wilson Sonsini Goodrich & Rosati, November 1, 2011: US08048902 (6 worldwide citation)

Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating L ...


6
John H Hutchinson, Petpiboon Peppi Prasit, Mark Moran, Jillian F Evans, Brian Andrew Stearns, Jeffrey Roger Roppe, Yiwei Li, Jasmine Eleanor Zunic, Jeannie M Arruda, Nicholas Simon Stock, Mustapha Haddach: 5-lipdxygenase-activating protein (FLAP) inhibitors. Amira Pharmaceuticals, Robert J Smith, July 12, 2011: US07977359 (5 worldwide citation)

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, ...


7
John H Hutchinson, Petpiboon Peppi Prasit, Mark Moran, Jillian F Evans, Brian Andrew Stearns, Jeffrey Roger Roppe, Yiwei Li, Jasmine Eleanor Zunic, Jeannie M Arruda, Nicholas Simon Stock, Mustapha Haddach: 5-lipoxygenase-activating protein (FLAP) inhibitors. Panmira Pharmaceuticals, Robert J Smith, March 19, 2013: US08399666 (4 worldwide citation)

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, ...


8
John Howard Hutchinson, Thomas Jonathan Seiders, Brian Andrew Stearns, Bowei Wang, Yen Pham Truong, Jeannie M Arruda: receptors, Cyclic diaryl ether compounds as antagonists of prostaglandin D. Panmira Pharmaceuticals, Wilson Sonsini Goodrich & Rosati, August 14, 2012: US08242145 (4 worldwide citation)

Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD2 receptors described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other c ...


9
Thomas Jon Seiders, Lucy Zhao, Jeannie M Arruda, Brian Andrew Stearns, Yen Pham Truong, Jill Melissa Scott, John Howard Hutchinson, Nicholas Simon Stock, Deborah Volkots: Compounds as lysophosphatidic acid receptor antagonists. Amira Pharmaceuticals, Maureen S Gibbons, July 10, 2012: US08217066 (4 worldwide citation)

Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating L ...


10
John Howard Hutchinson, Brian Andrew Stearns, Jill Melissa Scott, Yen Pham Truong, Jeffrey Roger Roppe, Nicholas Simon Stock, Jeannie M Arruda, Thomas Jon Seiders, Bowei Wang, Deborah Volkots: N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors. Panmira Pharmaceuticals, Wilson Sonsini Goodrich & Rosati, January 29, 2013: US08362044 (3 worldwide citation)

Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alo ...



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