1
Andreas Huth, Dieter Seidelmann, Karl Heinz Thierauch, Guido Bold, Paul William Manley, Pascal Furet, Jeanette Marjorie Wood, Jürgen Mestan, Jose Brüggen, Stefano Ferrari, Martin Krüger, Eckhard Ottow, Andreas Menrad, Michael Schirner: Anthranilic acid amides and the use thereof as medicaments. Schering, Novartis, Millen White Zelano & Branigan P C, October 17, 2006: US07122547 (36 worldwide citation)

The invention relates to anthranilic acid amides and the use thereof as medicaments for the treatment of diseases that are triggered by persistent angiogenesis, in addition to intermediate products in the production of anthranilic acid amides.


2

3

4
Karl Heinz Altmann, Guido Bold, Pascal Furet, Paul William Manley, Jeanette Marjorie Wood, Stefano Ferrari, Francesco Hofmann, Jürgen Mestan, Andreas Huth, Martin Krüger, Dieter Seidelmann, Andreas Menrad, Martin Haberey, Karl Heinz Thierauch: VEGF receptor tyrosine kinase inhibitors. Novartis, Schering Aktiengesellschaft, Lydia T McNally, George R Dohmann, April 12, 2005: US06878720 (22 worldwide citation)

Described are compunds of formula (I), wherein W is O or S; X is NR8; Y is CR9R10—(CH2)n wherein R9 and R10 are independently of each other hydrogen or lower alkyl, and n is an integer of from and including 0 to and including 3; or Y is SO2; R1 is aryl; R2 is a bicyclic heteroaryl group comprising o ...


5

6
Karl Heinz Altmann, Guido Bold, Pascal Furet, Paul William Manley, Jeanette Marjorie Wood, Stefano Ferrari, Francesco Hofmann, Jürgen Mestan, Andreas Huth, Martin Krüger, Dieter Seidelmann, Andreas Menrad, Martin Haberey, Karl Heinz Thierauch: N-Aryl (thio) anthranilic acid amide derivatives, their preparation and their use as VEGF. Novartis, Schering Aktiengesellschaft, Lydia T McNally, February 21, 2006: US07002022 (10 worldwide citation)

Described are compunds of formula (I), wherein W is O or S; X is NR8; Y is CR9R10—(CH2)n wherein R9 and R10 are independently of each other hydrogen or lower alkyl, and n is an integer of from and including 0 to and including 3; or Y is SO2; R2 is aryl; R2 is a mono- or bicyclic heteroaryl group com ...


7

8
Guido Bold, Janet Dawson King, Jörg Frei, Richard Heng, Paul William Manley, Bernhard Wietfeld, Jeanette Marjorie Wood: Phthalazine derivatives for treating inflammatory diseases. Novartis, D Gabrielle Brouillette, Carol A Loeschorn, February 3, 2004: US06686347 (6 worldwide citation)

The invention relates to the treatment of an inflammatory disease, especially an inflammatory rheumatoid or rheumatic disease, and/or pain with an inhibitor of the activity of VEGF receptor tyrosine kinase of the formula I,


9
Romulus Kimbro Brazzell, Jeanette Marjorie Wood, Peter Anthony Campochiaro, Frances Elizabeth Kane: Method for treating ocular neovascular diseases. CIBA Vision Corporation, David E Wildman, August 7, 2001: US06271233 (6 worldwide citation)

The invention relates to the use of certain phthalazines in the preparation of medicaments for the treatment of ocular neovascularization.


10
Heidi Lane, Terence O Reilly, Jeanette Marjorie Wood: Treatment of solid tumors with rapamycin derivatives. Novartis Pharmaceuticals Corporation, Ann R Pokalsky, Dilworth & Barrese, July 15, 2014: US08778962 (3 worldwide citation)

Rapamycin derivatives have interesting effects in the treatment of solid tumours, optionally in combination with a chemotherapeutic agent.