1
Nicholas D Cosford, Jean Michel Vernier: Substituted pyridines useful as modulators of acethylcholine receptors. SIBIA Neurosciences, Stephen E Gray Care Ware & Freidenrich Reiter, December 22, 1998: US05852041 (92 worldwide citation)

In accordance with the present invention, there provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists, antagoni ...


2
Jean Michel Vernier, Nicholas D P Cosford, Ian A McDonald: Substituted pyridine compounds useful as modulators of acetylcholine receptors. Merck & Co, David Rubin, David L Rose, October 14, 2003: US06632823 (39 worldwide citation)

In accordance with the present invention, a novel class of substituted pyridine compounds (optionally containing ether, ester, amide, ketone or thioether substitutions) that promote the release of ligands involved in neurotransmission have been discovered. In a particular aspect compounds of the pre ...


3
Nicholas D Cosford, Jean Michel Vernier: Substituted pyridines useful as modulators of acetylcholine receptors. Sibia Neurosciences, Stephen E Reiter, Pretty Schroeder Brueggemann & Clark, December 17, 1996: US05585388 (26 worldwide citation)

In accordance with the present invention, there is provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists, antag ...


4
Nicholas D Cosford, Jean Michel Vernier: Substituted pyridines useful as modulators of acetylcholine receptors. SIBIA Neurosciences, Stephen E Gary Cary Ware & Freidenrich Reiter, April 7, 1998: US05736560 (21 worldwide citation)

In accordance with the present invention, there is provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists, antag ...


5
Nicholas D Cosford, Jean Michel Vernier: Substituted pyridines useful as modulators of acetylcholine receptors. Merck & Co, Shu M Lee, David L Rose, February 27, 2001: US06194581 (17 worldwide citation)

In accordance with the present invention, there is provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists, antag ...


6
Andreas Maderna, Jean Michel Vernier, Dinesh Barawkar, Varaprasad Chamakura, Hassan el Abdellaoui, Zhi Hong: Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK. Ardea Biosciences, Millen White Zelano & Branigan P C, July 20, 2010: US07759518 (14 worldwide citation)

This invention concerns N-(2-arylamino)aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.


7
Jean Michel Vernier, Andreas Maderna, Yung hyo Koh, Zhi Hong: Inhibitors of MEK. Bayer Schering Pharma, Millen White Zelano & Branigan P C, October 26, 2010: US07820664 (14 worldwide citation)

This invention concerns to N-(2-aylamino)aryl sulfonamides, which are inhibitors of MEK, methods of using such compounds in the treatment of hyperproliferative diseases, and to pharmaceutical compositions containing such compounds.


8
Esmir Gunic, Jean Luc Girardet, Jean Michel Vernier, Martina E Tedder, David A Paisner: Compounds, compositions and methods of using same for modulating uric acid levels. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, May 8, 2012: US08173690 (10 worldwide citation)

Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.


9
Peter Charles Astles, Stephen Richard Baker, Rowena Villanueva Cube, Jose Antonio Martinez Perez, Ana Isabel Mateo Herranz, Jean Michel Vernier, Colin Peter Dell, Sonia Gutierrez, Lourdes Prieto, Martine Keenan, Adam Jan Sanderson, Colin William Smith: Modulators of acetylcholine receptors. Merck & Co, John C Todaro, Melvin Winokur, December 12, 2006: US07148236 (10 worldwide citation)

The present invention relates to compounds that modulate neurotransmission by promoting the release of neurotransmitters such as acetylcholine, dopamine and norepinephrine. More particularly, the present invention relates to thio-bridged aryl compounds that are capable of modulating acetylcholine re ...


10
Andreas Maderna, Jean Michel Vernier, Dinesh Barawkar, Varaprasad Chamakura, Hassan El Abdellaoui, Zhi Hong: Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK. Ardea Biosciences, Millen White Zelano & Branigan P C, January 24, 2012: US08101799 (8 worldwide citation)

This invention concerns N—(2-arylamino) aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.



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