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Jean Michel Vernier, Colin Edward Rowlings, Jean Luc Girardet, Stuart Dimock, Barry Quart, Jeffrey N Miner: Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same. Ardea Biosciences, March 10, 2011: US20110060049-A1

This invention concerns N-(2-arylamino) aryl sulfonamide compounds which are inhibitors of MEK including crystalline polymorphic forms which exhibit a specific powder x-ray diffraction profile and/or a specific differential scanning calorimetry profile. This invention also concerns pharmaceutical co ...


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Barry D Quart, Jean Luc Girardet, Esmir Gunic, Li Tain Yeh: Novel compounds and compositions and methods of use. Ardea Biosciences, December 1, 2011: US20110293719-A1

Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.


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Jean Luc Girardet, Yung Hyo Koh, Martha De La Rosa, Esmir Gunic, Zhi Hong, Stanley Lang, Woo Hong Kim: S-triazolyl alpha-mercapto acetanilides as inhibitors of hiv reverse transcriptase. Ardea Biosciences, December 22, 2011: US20110313157-A1

A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.


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Jean Luc Girardet, Yung hyo Koh, Martha de la Rosa, Zhi Hong, Stanley Lang: N[s(4-aryl-triazol-3-yl)alpha-mercaptoacetyl]-p-amino benzoic acids as hiv reverse transcriptase inhibitors. Ardea Biosciences, March 29, 2012: US20120077981-A1

A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. are provided, where Q is CO2H, or a salt or ester thereof, or a C(O) N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the tre ...


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Jean Luc Girardet, Yung Hyo Koh, Martha De La Rosa, Esmir Gunic, Zhi Hong, Stanley Lang, Woo Hong Kim: S-triazolyl alpha-mercapto acetanilides as inhibitors of hiv reverse transcriptase. Ardea Biosciences, November 8, 2012: US20120283301-A1

A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.


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Barry D Quart, Jean Luc Girardet, Esmir Gunic, Li Tain Yeh: Novel compounds and compositions and methods of use. Ardea Biosciences, November 3, 2011: US20110268801-A1

Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.


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Barry D Quart, Jean Luc Girardet, Esmir Gunic, Li Tain Yeh: Novel compounds and compositions and methods of use. Ardea Biosciences, June 28, 2012: US20120164222-A1

Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.


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Gabriel Galvin, Laszlo R Treiber, Irina Zamansky, Jean Luc Girardet: Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio)acetic acid and uses thereof. Ardea Biosciences, July 5, 2012: US20120172405-A1

Crystalline polymorph forms of 2-(5-bromo-4-(4-cyclopropyl naphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid are described. Pharmaceutical compositions and the uses of such compounds, compound forms, and compositions for the treatment of a variety of diseases and conditions are also presented.


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