51
Esmir Gunic, Jean Luc Girardet, Jean Michel Vernier, Martina E Tedder, David A Paisner: Compounds, compositions and methods of using same for modulating uric acid levels. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, March 4, 2010: US20100056465-A1

Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.


52
Jean Luc Girardet, Yung Hyo Koh: 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio)acetic acid and methyl ester. Wilson Sonsini Goodrich & Rosati, March 18, 2010: US20100069645-A1

A series of S-triazolyl α-mercaptoacetanilides having general structure (I) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.


53
Jean Luc Girardet, Yung Hyo Koh: 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio)acetic acid and methyl ester. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, April 1, 2010: US20100081827-A1

A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2. SO3H or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.


54
Jean Luc Girardet, Zhi Hong, Stephanie Shaw, Yung hyo Koh: 4-cyanophenylamino-substituted bicyclic heterocyclic compounds as hiv inhibitors. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, November 12, 2009: US20090281124-A1

This application concerns certain 4-cyanophenylamino-substituted bicyclic heterocycles of formula I where the dashed line represents a double bond that may be located either between A and C(V) or between C(V) and D, where A is S or C(Z); D is S or C(W); provided that one and only one of A and D is S ...


55
Jean Luc Girardet, Yung Hyo Koh, Stephanie Shaw, Hong Woo Kim: Diaryl-purines, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitor for treatment of hiv. Wilson Sonsini Goodrich & Rosati, May 14, 2009: US20090124802-A1

This application concerns certain 2-phenylamino-6-aryl amino-, 6-aryloxy-, and 6-arylthio-purines, -azapurines and -deazapurines. These compounds are non-nucleoside reverse transcriptase inhibitors and have potential as anti-HIV treatment.


56
Martha De La Rosa, Jean Luc Girardet: Compounds, Compositions and Methods for Modulating Uric Acid Levels. Ardea Biosciences, May 17, 2012: US20120122780-A1

Described herein are compounds useful in the reduction of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.


57
Martha De La Rosa, Jean Luc Girardet, Karen Watson: Methods Of Modulating Uric Acid Levels. Ardea Biosciences, May 31, 2012: US20120135929-A1

Described herein are compounds useful in the reduction of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, a compound disclosed herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.


58
Irina Zamansky, Jean Luc Girardet, Gabriel Galvin: Polymorphic, crystalline and mesophase forms of sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio) acetate, and uses thereof. Ardea Biosciences, May 24, 2012: US20120129903-A1

Crystalline polymorphs and solid mesophase forms of sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate are described. In addition, pharmaceutical compositions and uses of such compositions for the treatment of a variety of diseases and conditions are provided.


59
Jean Luc GIRARDET, Zhi HONG, Stephanie SHAW, Yung hyo KOH: Substituted Thienol[2,3-d] pyrimidines as HIV Inhibitors. Ardea Biosciences, September 6, 2012: US20120225894-A1

This application concerns certain 4-cyanophenylamino-substituted bicyclic heterocycles of formula I where the dashed line represents a double bond that may be located either between A and C(V) or between C(V) and D, where A is S or C(Z); D is S or C(W); provided that one and only one of A and D is S ...


60
Jean Luc Girardet, Yung Hyo Koh, Stephanie Shaw, Hong Woo Kim, Zhi Hong: Pyrrolo [2,3-d] pyrimidines as non-nucleoside reverse transcriptase inhibitors for treatment of hiv. Ardea Biosciences, September 6, 2012: US20120226037-A1

This application concerns certain 2-phenylamino-6-aryl amino-, 6-aryloxy-, and 6-arylthio-purines, -azapurines and -deazapurines. These compounds are non-nucleoside reverse transcriptase inhibitors and have potential as anti-HIV treatment.