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Jean Luc Girardet, Yung Hyo Koh, Martha De La Rosa, Zhi Hong, Stanley Lang: -amino benzoic acids as HIV reverse transcriptase inhibitors, N[S(4-aryl-triazol-3-yl)α-mercaptoacetyl]-. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, October 8, 2013: US08552043 (3 worldwide citation)

A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. are provided, where Q is CO2H, or a salt or ester thereof, or a C(O) N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the tre ...


22
Jean Luc Girardet, Yung Hyo Koh, Martha De La Rosa, Esmir Gunic, Zhi Hong, Stanley Lang, Hong Woo Kim: S-triazolyl α-mercaptoacetanilides as inhibitors of HIV reverse transcriptase. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, July 9, 2013: US08481581 (3 worldwide citation)

A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.


23
Jean Luc Girardet, Yung Hyo Koh, Martha De La Rosa, Esmir Gunic, Zhi Hong, Stanley Lang, Hong Woo Kim: S-triazolyl α-mercapto acetanilides as inhibitors of HIV reverse transcriptase. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, August 28, 2012: US08252828 (3 worldwide citation)

A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.


24
Esmir Gunic, Jean Luc Girardet, David A Paisner: Compounds, compositions and methods of using same for modulating uric acid levels. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, January 1, 2013: US08344012 (2 worldwide citation)

Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.


25
Irina Zamansky, Jean Luc Girardet, Gabriel Galvin: -1,2,4-triazol-3-ylthio) acetate, and uses thereof, Polymorphic, crystalline and mesophase forms of sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, September 3, 2013: US08524754 (2 worldwide citation)

Crystalline polymorphs and solid mesophase forms of sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate are described. In addition, pharmaceutical compositions and uses of such compositions for the treatment of a variety of diseases and conditions are provided.


26
Jeffrey Miner, Jean Luc Girardet, Barry D Quart: Treatment of gout. ARDEA BIOSCIENCES, Wilson Sonsini Goodrich & Rosati, August 2, 2016: US09402827

Sodium 2-(5-bromo-4-(4-cyclopropyl-naphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate is described. In addition, pharmaceutical compositions and uses such compositions for the treatment of a variety of diseases and conditions.


27
Jeffrey Miner, Jean Luc Girardet, Barry D Quart: Treatment of gout and hyperuricemia. ARDEA BIOSCIENCES, Wilson Sonsini Goodrich & Rosati, December 22, 2015: US09216179

Sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate is described. In addition, pharmaceutical compositions and uses of such compositions for the treatment of a variety of diseases and conditions are described.


28
Jean Luc Girardet, Yung Hyo Koh, Stephanie Shaw, Hong Woo Kim, Zhi Hong: Diaryl-purines, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitor for treatment of HIV. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, July 24, 2012: US08227601

This application concerns certain 2-phenylamino-6-aryl amino-, 6-aryloxy-, and 6-arylthio-purines, -azapurines and -deazapurines. These compounds are non-nucleoside reverse transcriptase inhibitors and have potential as anti-HIV treatment.


29
Jean Luc Girardet, Yung hyo Koh, Stephanie Shaw, Hong Woo Kim, Zhi Hong: Pyrrolo [2,3-D] pyrimidines as non-nucleoside reverse transcriptase inhibitors for treatment of HIV. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, January 15, 2013: US08354532

This application concerns certain 2-phenylamino-6-aryl amino-, 6-aryloxy-, and 6-arylthio-purines, -azapurines and -deazapurines. These compounds are non-nucleoside reverse transcriptase inhibitors and have potential as anti-HIV treatment.


30
Jean Luc Girardet, Zhi Hong, Stephanie Shaw, Yung hyo Koh: Substituted thieno[3,2-d]pyrimidines as HIV inhibitors. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, July 3, 2012: US08211898

This application concerns certain 4-cyanophenylamino-substituted bicyclic heterocycles of formula I where the dashed line represents a double bond that may be located either between A and C(V) or between C(V) and D, where A is S or C(Z); D is S or C(W); provided that one and only one of A and D is S ...