11
Zhi Hong, Yung hyo Koh, Jae Hoon Shim, Jean Luc Girardet: Antiviral phosphonate compounds and methods therefor. Valeant Research & Development, Thelen Reid Brown Raysman & Steiner, July 24, 2007: US07247621 (8 worldwide citation)

Pharmaceutical compositions comprise a nucleotide analog with a phosphonate group at a concentration effective to act as a substrate and/or inhibitor of a viral polymerase, and especially of the HCV RNA dependent RNA polymerase.


12
Barry D Quart, Jean Luc Girardet, Esmir Gunic, Li Tain Yeh: Compounds and compositions and methods of use. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, October 9, 2012: US08283369 (7 worldwide citation)

Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.


13
Esmir Gunic, Jean Luc Girardet, Jean Michel Vernier, Martina E Tedder, David A Paisner: Compounds, compositions and methods of using same for modulating uric acid levels. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, August 14, 2012: US08242154 (7 worldwide citation)

Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.


14
Jean Michel Vernier, Colin Edward Rowlings, Jean Luc Girardet, Stuart Dimock, Barry Quart, Jeffrey N Miner: Derivatives of N-(arylamino) sulfonamides including polymorphs as inhibitors of MEK as well as compositions, methods of use and methods for preparing the same. Ardea Biosciences, Millen White Zelano & Branigan P C, February 11, 2014: US08648116 (7 worldwide citation)

This invention concerns N-(2-arylamino) aryl sulfonamide compounds which are inhibitors of MEK including crystalline polymorphic forms which exhibit a specific powder x-ray diffraction profile and/or a specific differential scanning calorimetry profile. This invention also concerns pharmaceutical co ...


15
Barry D Quart, Jean Luc Girardet, Esmir Gunic, Li Tain Yeh: Compounds and compositions and methods of use. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, January 22, 2013: US08357713 (5 worldwide citation)

Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.


16
Laszlo R Treiber, Gabriel Galvin, Irina Zamansky, Jean Luc Girardet: -1,2,4-triazol-3-ylthio)acetic acid and uses thereof, Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, October 1, 2013: US08546436 (4 worldwide citation)

Crystalline polymorph forms of 2-(5-bromo-4-(4-cyclopropyl naphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid are described. Pharmaceutical compositions and the uses of such compounds, compound forms, and compositions for the treatment of a variety of diseases and conditions are also presented.


17
Jean Luc Girardet, Zhi Hong, Stephanie Shaw, Yung hyo Koh: Substituted thieno[3,2-D]pyrimidines as HIV inhibitors. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, September 29, 2009: US07595324 (4 worldwide citation)

This application concerns certain 4-cyanophenylamino-substituted bicyclic heterocycles of formula I where the dashed line represents a double bond that may be located either between A and C(V) or between C(V) and D, where A is S or C(Z); D is S or C(W); provided that one and only one of A and D is S ...


18
Barry D Quart, Jean Luc Girardet, Esmir Gunic, Li Tain Yeh: Compounds and compositions and methods of use. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, October 1, 2013: US08546437 (3 worldwide citation)

Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.


19
Martha De La Rosa, Jean Luc Girardet, Karen Watson: Methods of modulating uric acid levels. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, February 12, 2013: US08372807 (3 worldwide citation)

Described herein are compounds useful in the reduction of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, a compound disclosed herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.


20
Esmir Gunic, Jean Luc Girardet, Jean Michel Vernier, Martina E Tedder, David A Paisner: Compounds, compositions and methods of using same for modulating uric acid levels. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, January 21, 2014: US08633232 (3 worldwide citation)

Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.