1
Zhi Hong, Jean Luc Girardet, Kanda Ramasamy, Johnson Lau: Nucleoside compounds and uses thereof. Ribapharm, Brown Raysman Millstein Felder & Steiner, November 9, 2004: US06815542 (68 worldwide citation)

Nucleosides, novel nucleoside analog compounds and their novel prodrug forms are disclosed. The novel compounds, prodrugs, or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to treat an infection, an infestation, a neo ...


2
Zbigniew Pietrzkowski, Guangyi Wang, Johnson Lau, Zhi Hong, Jean Luc Girardet, Esmir Gunic: Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine nucleosides. Valeant Research & Development, Brown Raysman Millstein Felder & Steiner, July 25, 2006: US07081449 (43 worldwide citation)

A purine nucleoside analog includes a pyrido[2,3-d]pyrimidine or a pyrimido[4,5-d]pyrimidine and further has a sugar moiety that is optionally modified at the C2′, C3′, C4′ and/or C5′ position. Particularly contemplated compounds also include prodrug forms of the purine nucleoside analogs, and both ...


3
Jean Luc Girardet, Yung hyo Koh, Martha de la Rosa, Zhi Hong, Stanley Lang: -amino benozioc acids as HIV reverse transcriptase inhibitors, N[S(4-aryl-triazol-3-yl)α-mercaptoacetyl]-. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, October 14, 2008: US07435752 (25 worldwide citation)

A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. are provided, where Q is CO2H, or a salt or ester thereof, or a C(O)N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the trea ...


4
Jean Luc Girardet, Martha de la Rosa, Zhi Hong, Stanley Lang: -amino benzoic acids as HIV reverse transcriptase inhibitors, N[S(4-aryl-triazol-3-yl)α-mercaptoacetyl] -. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, March 23, 2010: US07683087 (19 worldwide citation)

A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. are provided, where Q is CO2H, or a salt or ester thereof, or a C(O) N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the tre ...


5
Barry D Quart, Jean Luc Girardet, Esmir Gunic, Li Tain Yeh: Compounds and compositions and methods of use. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, December 27, 2011: US08084483 (17 worldwide citation)

Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.


6
Jean Luc Girardet, Yung Hyo Koh: 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid and methyl ester. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, August 23, 2011: US08003681 (17 worldwide citation)

A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.


7
Jean Luc Girardet, Yung Hyo Koh, Martha De La Rosa, Esmir Gunic, Zhi Hong, Stanley Lang, Woo Hong Kim: S-triazolyl α-mercaptoacetanilides as inhibitors of HIV reverse transcriptase. Ardes Biosciences, Wilson Sonsini Goodrich & Rosati, May 24, 2011: US07947721 (13 worldwide citation)

A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.


8
Esmir Gunic, Jean Luc Girardet, Jean Michel Vernier, Martina E Tedder, David A Paisner: Compounds, compositions and methods of using same for modulating uric acid levels. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, May 8, 2012: US08173690 (10 worldwide citation)

Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.


9
Jean Luc Girardet, Yung hyo Koh, Martha De La Rosa, Zhi Hong, Stanley Lang: -amino benzoic acids as HIV reverse transcriptase inhibitors, N[S(4-aryl-triazol-3-yl)α-mercaptoacetyl]. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, January 31, 2012: US08106205 (9 worldwide citation)

A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. are provided, where Q is CO2H, or a salt or ester thereof, or a C(O) N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the tre ...


10
Esmir Gunic, Jean Luc Girardet, David A Paisner: Compounds, compositions and methods of using same for modulating uric acid levels. Ardea Biosciences, Wilson Sonsini Goodrich & Rosati, June 5, 2012: US08193234 (8 worldwide citation)

Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.