Jan Steyaert (1 - 10 of 11 results)


1
Jan Steyaert, Els Pardon, Soren Rasmussen, Juan Fung, Brian Kobilka, Toon Laeremans: Protein binding domains stabilizing functional conformational states of GPCRs and uses thereof. VIB VZW, Vrije Universiteit Brussel, The Board of Trustees of the Leland Stanford Junior University, TraskBritt P C, September 27, 2016: US09453065 (4 worldwide citation)

The disclosure relates to the field of GPCR structure biology and signaling. In particular, it relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, it provides protein bi ...

2
Serge Muyldermans, Jan Steyaert, Karen Silence, Els Torreele: Recombinant phages capable of entering host cells via specific interaction with an artificial receptor. Vlaams Interuniversitair Institutuut voor Biotechnologie VZW, Fish & RIchardson P C P A, November 12, 2002: US06479280 (3 worldwide citation)

The invention relates to a genetically modified bacteriophage, pseudovirion or phagemid capable of entering a host cell by binding of its artificial ligand to an artificial receptor present on said host cell. The invention relates also to the use of the genetically modified bacteriophage, pseudoviri ...

3
Jan Steyaert, Juan Jose Fung, Brian Kobilka, Toon Laeremans, Els Pardon, Soren G F Rasmussen: Protein binding domains stabilizing functional conformational states of GPCRs and uses thereof. VIB VZW, Vrije Universiteit Brussel, The Board of Trustees of the Leland Stanford Junior University, TraskBritt P C, June 27, 2017: US09689872 (2 worldwide citation)

The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifical ...

4
Jan Steyaert, Toon Laeremans, Els Pardon: Chimeric polypeptides comprising G protein-coupled receptors and VHH antibodies. VIB VZW, Vrije Universiteit Brussel, TraskBritt P C, March 14, 2017: US09593157

Described are polypeptides and their use for screening and drug discovery. More specifically, the disclosure provides chimeric polypeptides comprising a membrane protein, in particular a GPCR, fused to a binding domain, wherein the binding domain is directed against and/or specifically binds to the ...

5
Jan Steyaert, Els Pardon, Soren G F Rasmussen, Juan Jose Fung, Brian Kobilka, Toon Laeremans: Protein binding domains stabilizing functional conformational states of GPCRs and uses thereof. VIB VZW, Vrije Universiteit Brussel, The Board of Trustees of the leland Stanford Junior University, Patent Law Works, September 18, 2018: US10078088

The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifical ...

6
Jan Steyaert, Els Pardon, Soren G F Rasmussen, Juan Jose Fung, Brian Kobilka, Toon Laeremans: Protein binding domains stabilizing functional conformational states of GPCRs and uses thereof. VIB VZW, VRIJE UNIVERSITEIT BRUSSEL, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, TraskBritt P C, August 21, 2018: US10054598

The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifical ...

7
Jan Steyaert, Els Pardon, Soren G F Rasmussen, Juan Jose Fung, Brian Kobilka, Toon Laeremans: Protein binding domains stabilizing functional conformational states of GPCRS and uses thereof. VIB VZW, VRIJE UNIVERSITEIT BRUSSEL, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, TraskBritt P C, January 9, 2018: US09863959

The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifical ...

8
Jan Steyaert, Nico Callewaert, Toon Laeremans, Els Pardon, Kristof Vandewalle, Katrien Claes: Tools and methods for expression of membrane proteins. VIB VZW, VRIJE UNIVERSITEIT BRUSSEL, UNIVERSITEIT GENT, TraskBritt P C, February 13, 2018: US09890217

The disclosure relates cells or cellular systems that express both a membrane protein and a binding domain directed to the membrane protein. Also, methods are provided that use such cells or cellular systems to produce higher amounts of the membrane proteins. Further, the cells or cellular systems c ...

9
Els Pardon, Jan Steyaert, Lode Wyns: Epitope tag for affinity-based applications. VIB VZW, Vrije Universiteit Brussel, TraskBritt P C, December 13, 2016: US09518084

Described is an epitope tag useful in affinity-based applications. The invention further includes fusion proteins, methods for preparing fusion proteins, nucleic acid molecules encoding these fusion proteins and recombinant host cells that contain these nucleic acid molecules. The invention also rel ...

10
Serge Muyldermans, Jan Steyaert, Karen Silence, Els Torreele: Recombinant phages capable of entering host cells via specific interaction with an artificial receptor. VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW a Belgium corporation, Mark S Ellinger Phd, Fish & Richardson PC PA, August 7, 2003: US20030148508-A1

The invention relates to a genetically modified bacteriophage, pseudovirion or phagemid capable of entering a host cell by binding of its artificial ligand to an artificial receptor present on said host cell. The invention relates also to the use of the genetically modified bacteriophage, pseudoviri ...