1
James R Spears: Method for treating an arterial wall injured during angioplasty. Wayne State University, Brooks & Kushman, March 3, 1992: US05092841 (378 worldwide citation)

A method for treating a lesion in an arterial wall having plaque thereon and a luminal surface, the arterial wall having been mechanically injured during an angioplasty procedure, the arterial wall and the plaque including fissures resulting therefrom, the method comprising the steps of positioning ...


2
James R Spears: Method of treatment of atherosclerosis and a balloon catheter for same. The Beth Israel Hospital Association, Anthony M Lorusso, April 23, 1985: US04512762 (251 worldwide citation)

A method for the treatment of atherosclerosis in a mammal by destruction of atheromatous plaque is disclosed. The disclosed method includes injecting a hematoporphyrin into the mammal for selective uptake into the atheromatous plaque, and delivering light to the diseased vessel so that the light act ...


3
James R Spears: Method of drug application in a transporting medium to an arterial wall injured during angioplasty. Wayne State University, Brooks & Kushman, April 6, 1993: US05199951 (136 worldwide citation)

A method for treating a lesion (27) in an arterial wall (28) having plaque (52) thereon and a luminal surface (29). The arterial wall (28) has typically been mechanically injured during an angioplasty procedure. As a result of that procedure, the arterial wall (28) and the plaque (52) include fissur ...


4
James R Spears: Method and apparatus for calibrating rapid sequence radiography. Freilich Hornbaker Wasserman Rosen & Fernandez, August 23, 1983: US04400827 (64 worldwide citation)

By moving a wedge (18) within the radiographic field during exposure of an area of interest, steps of the wedge are presented one by one at the same film location over sequential exposures. Wedge steps are thus superimposed over an identical position within the radiographic field, and a correlation ...


5
James R Spears: Apparatus and method for making a diffusing tip in a balloon catheter system. Wayne State University, Brooks & Kushman, September 6, 1994: US05344419 (63 worldwide citation)

An apparatus and method are disclosed for making a laser balloon catheter (10) having a diffusing tip (24) for propagating a uniform cylindrical pattern of laser energy. Included in the catheter are an elongated flexible tube (12) with an inflatable balloon (14) connected to the tube and means for i ...


6
James R Spears: Method and apparatus for injection of gas hydrates. Wayne State University, Brooks & Kushman, November 16, 1993: US05261875 (54 worldwide citation)

A method of gasification of an environment having the characteristic of a low concentration of gas. The method is particularly suited for oxygenation of hypoxemic blood. The method comprises the steps of preparing a powdered oxygen hydrate; mixing the hydrate with powdered ice; pulverizing the mixtu ...


7
James R Spears: Method of microencapsulation of hyperbaric gas. Wayne State University, Brooks & Kushman, February 11, 1992: US05086620 (51 worldwide citation)

Method of encapsulating a hyperbaric gas for the treatment of diseases in humans with encapsulated gaseous precursors, such as microbubbles of oxygen. The method includes the step of immersing a receptacle containing an encapsulating material into a reaction vessel. An ultrasonic probe is then inser ...


8
James R Spears: Apparatus and method of delivery of gas-supersaturated liquids. Wayne State University, Brooks & Kushman PC, February 4, 1997: US05599296 (39 worldwide citation)

An apparatus 10 for delivery of a gas, such as oxygen, solution into an environment (such as a coronary artery). The apparatus includes a high pressure tubular housing 12 defining a lumen 14 therewithin. A plurality of axially disposed concentric tubes 16 are supported within the lumen 14. Each defi ...


9
James R Spears: Method for delivering a gas-supersaturated fluid to a gas-depleted site and use thereof. Wayne State University, Brooks & Kushman PC, October 29, 1996: US05569180 (36 worldwide citation)

A method of injecting gas-supersaturated fluids as a bubble-free effluent from a delivery system into a relatively low pressure, gas-depleted environment without cavitation or bubble formation. The method includes the steps of eliminating cavitation nuclei from within the delivery system, compressin ...


10
James R Spears: Method and apparatus for delivering oxygen into blood. Wayne State University, Brooks & Kushman, April 18, 1995: US05407426 (33 worldwide citation)

A method and apparatus for delivering oxygen into an environment of interest, such as blood plasma, having the characteristic of a low concentration of oxygen before delivery. The method includes the steps of preparing a mixture of oxygen and a liquid, compressing the mixture so that the oxygen diss ...