1
James P Tam: Multiple antigen peptide system. The Rockefeller University, Wyatt Gerber Burke and Badie, July 20, 1993: US05229490 (191 worldwide citation)

Multiple antigen peptide systems are described in which a large number of antigens are bound to the functional groups of a dendritic core molecule providing a high concentration of antigen in a low molecular volume. The products are useful for producing chemically defined univalent or multivalent va ...


2
James P Tam: Multiple antigen peptide system having adjuvant properties, vaccines prepared therefrom and methods of use thereof. Klauber & Jackson, December 3, 1996: US05580563 (60 worldwide citation)

A multiple antigenic peptide system is disclosed that comprises a dendritic core and peptide and a lipophilic anchoring moiety. This particular combination has as an advantage that it eliminates the need for the inclusion of adjuvants found to be toxic to humans, and facilitates the exponential ampl ...


3
James P Tam, William F Heath Jr, Robert B Merrifield: Peptide synthesis reagents and method of use. Research Corporation, Scully Scott Murphy & Presser, March 26, 1985: US04507230 (52 worldwide citation)

A method of releasing a functional group present in an amino acid or amino acyl residue from a resin or protecting residue which is bonded to the functional group by a linkage having proton affinity, which comprises: reacting the functional group bonded to the organic residue, with a mixture of HF a ...


4
James P Tam: Method for synthesis of proteins. Vanderbilt University, Klauber & Jackson, October 30, 2001: US06310180 (32 worldwide citation)

A method for peptide synthesis is disclosed that requires neither protecting groups nor activation of the C-&agr; carboxyl groups. The method comprises ligating a first molecule to a second molecule by promoting the orthogonal coupling of the molecules to each other. In an aspect of this method, an ...


5
Rolf H Berg, Kristoffer Almdal, Walther B Pedersen, Arne Holm, James P Tam, Robert B Merrifield: Peptide synthesis method and solid support for use in the method. Riso National Laboratory, Wyatt Gerber Burke and Badie, November 2, 1993: US05258454 (15 worldwide citation)

A method for the solid-phase synthesis of peptides or proteins in high yield and high purity uses a solid-support consisting of a functionalized polystyrene-grafted polymer substrate, the grafted polystyrene chains being substantially non-cross-linked and having a chain molecular weight, not includi ...


6
James P Tam: Litigation of sidechain unprotected peptides via a masked glycoaldehyde ester and O,N-acyl rearrangement. Vanderbilt University, Klauber & Jackson, December 31, 1996: US05589356 (14 worldwide citation)

A method of chemical ligation of peptides that requires no side chain protecting groups and no activation of the C-.alpha. carboxyl group is presented. The method consists of three steps. In the first step, initiation, a masked glycoaldehyde ester is enzymatically or chemically coupled to the C-term ...


7
James P Tam: Oxidative folding of peptide and protein substrates using hydrocarbon sulfoxides. The Rockefeller University, Wyatt Gerber Burke & Badie, September 1, 1992: US05144006 (9 worldwide citation)

Method for oxidative folding of peptide and protein substrates to form disulfide bonds using dimethyl sulfoxide and other equivalent sulfoxides as mild oxidizing agents.


8
Rolf H Berg, Kristoffer Almdal, Walther B Pedersen, Arne Holm, James P Tam, Robert B Merrifield: Peptide synthesis method and solid support for use in the method. Riso National Laboratory, Henry T Burke, December 13, 1994: US05373053 (2 worldwide citation)

A method for the solid-phase synthesis of peptides or proteins in high yield and high purity uses a solid support consisting of a functionalized polystyrene-grafted polymer substrate, the grafted polystyrene chains being substantially non-cross-linked and having a chain molecular weight, not includi ...


9
James P Tam: Modified transforming growth factor alpha oligopeptides and pharmaceutical compositions thereof. The Rockefeller University, Wyatt Gerber Burke & Badie, January 26, 1993: US05182261 (1 worldwide citation)

This invention relates to transforming growth factor alpha modified by replacement of an L-amino acid residue with a D-amino acid residue and pharmaceutical compositions thereof useful in wound healing, ulcer treatment or trauma.


10
James P Tam, Qitao Yu, Yi An Lu, Jin Long Yang: Compositions of protein mimetics and methods of using same against HIV-1, SARS-coV and the like. Vanderbilt University, Morris Manning & Martin, May 26, 2005: US20050113292-A1

The present invention provides compositions of protein mimetics and methods of using same against HIV-1, SARS-coV and the like. In one aspect, the present invention relates to a protein mimetic for preventing HIV-1 entry to host cells of a living subject through membrane fusion, wherein HIV-1 contai ...