1
Mark Munson, David A Mareska, Youngboo Kim, Robert D Gronenberg, James P Rizzi, Martha Rodriguez, Ganghyeok Kim, Guy Vigers, Chang Rao, Devan Balachari, Darren Harvey: P38 inhibitors and methods of use thereof. Array BioPharma, John R Moore Esq, Viksnins Harris & Padys PLLP, September 21, 2010: US07799782 (190 worldwide citation)

This invention relates to inhibitors of p38 and methods of utilizing the inhibitors and pharmaceutical compositions thereof in the treatment and prevention of various disorders mediated by p38.


2
Ralph P Robinson, James P Rizzi: Arylsulfonylamino hydroxamic acid derivatives. Pfizer, Peter C Richardson, Paul H Ginsburg, Gezina Holtrust, January 26, 1999: US05863949 (75 worldwide citation)

A compound of formula (I), wherein n, X, R.sup.3, R.sup.4 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, scleritis and other diseases characterized ...


3
Anthony Piscopio, James P Rizzi: Arylsulfonyl hydroxamic acid derivatives as MMP and TNF inhibitors. Pfizer, Peter C Richardson, Paul H Ginsburg, Gezina Holtrust, January 19, 1999: US05861510 (74 worldwide citation)

A compound of the formula ##STR1## wherein R.sup.1, R.sup.2 R.sup.3, R.sup.4 R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9 and Ar are as defined above, useful in the treatment of a condition seiected from the group consisting of arthritis, cancer, tisuue ulceration, restenosis, periodontal disease, ep ...


4
David A Clark, Steven W Goldstein, Gerald F Holland, Bernard Hulin, James P Rizzi: Thiazolidinedione hypoglycemic agents. Pfizer, Peter C Richardson, Gregg C Benson, Mervin E Brokke, June 29, 1993: US05223522 (31 worldwide citation)

Hypoglycemic thiazolidine-2,4-dione derivatives of the formula ##STR1## wherein the dotted line represents a bond or no bond;


5
David A Clark, Steven W Goldstein, Gerald F Holland, Bernard Hulin, James P Rizzi: Thiazolidinedione hypoglycemic agents. Pfizer, Peter C Richardson, J Trevor Lumb, Mervin E Brokke, June 9, 1992: US05120754 (27 worldwide citation)

Hypoglycemic thiazolidine-2,4-dione derivatives of the formula ##STR1## wherein the dotted line represents a bond or no bond; A and dB are each independently CH or N, with the proviso that when A or B is N, the other is CH;


6
David A Clark, Steven W Goldstein, Gerald F Holland, Bernard Hulin, James P Rizzi: Thiazolidinedione hypoglycemic agents. Pfizer, Peter C Richardson, J Trevor Lumb, Mervin E Brokke, October 29, 1991: US05061717 (26 worldwide citation)

Hypoglycemic thiazolidine-2,4-dione derivatives of the formula ##STR1## wherein the dotted line represents a bond or no bond; A and B are each independently CH or N, with the proviso that when A or B is N, the other is CH;


7
Jeffery A Zablocki, Eugene Tarlton Jr, James P Rizzi, Nathan B Mantlo: Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents. Amgen, Frank Ungemach, Steven M Odre, January 30, 2001: US06180643 (15 worldwide citation)

The present invention comprises a new class of novel aryl and heteroaryl substituted fused pyrrole compounds useful for the prophylaxis and treatment of diseases or conditions, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. In particu ...


8
Jeffery A Zablocki, Eugene Tarlton Jr, James P Rizzi, Nathan B Mantlo: Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents. Amgen, Steven M Odre, Ron K Levy, Frank S Ungemach, August 27, 2002: US06440973 (12 worldwide citation)

The present invention comprises a new class of novel aryl and heteroaryl substituted fused pyrrole compounds useful for the prophylaxis and treatment of diseases or conditions, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. In particu ...


9
Laurence E Burgess, James P Rizzi: Compounds which inhibit tryptase activity. Array Biopharma, McDonnell Boehnen Hulbert & Berghoff, March 26, 2002: US06362216 (10 worldwide citation)

The present invention is directed to compounds which are capable of inhibiting the activity of tryptase. Such compounds are useful in the treatment or prevention of inflammatory disease, particularly those disease states which are mediated by mast cell activation. Also encompassed by the invention a ...


10
Arthur A Nagel, James P Rizzi, Terry J Rosen: Arylthiazolylimidazoles. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, April 3, 1990: US04914207 (10 worldwide citation)

Arylthiazolylimidazoles as 5HT.sub.3 antagonists useful in the treatment of nausea, anxiety, pain, schizoprenia and gastrointestinal disorders.