1
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin: Very large scale immobilized polymer synthesis using mechanically directed flow paths. Affymax Technologies, Kevin R Kaster, Vern Norviel, January 24, 1995: US05384261 (398 worldwide citation)

A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are flowed through the channels, the substrate is rotated by a rotatin ...


2
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin, Douglas N Modlin: Combinatorial strategies for polymer synthesis. Affymax Technologies, Townsend and Townsend and Crew, October 14, 1997: US05677195 (250 worldwide citation)

A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rota ...


3
R Fabian Pease, Glenn McGall, Martin J Goldberg, Richard P Rava, Stephen P A Fodor, Virginia Goss, Lubert Stryer, James L Winkler: Printing molecular library arrays using deprotection agents solely in the vapor phase. Affymetrix, Townsend & Townsend & Crew, February 4, 1997: US05599695 (217 worldwide citation)

A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier material, among ot ...


4
Earl A Hubbell, Robert J Lipshutz, Macdonald S Morris, James L Winkler: Computer-aided engineering system for design of sequence arrays and lithographic masks. Affymetrix, Townsend & Townsend & Crew, January 14, 1997: US05593839 (199 worldwide citation)

An improved set of computer tools for forming arrays. According to one aspect of the invention, a computer system is used to select probes and design the layout of an array of DNA or other polymers with certain beneficial characteristics. According to another aspect of the invention, a computer syst ...


5
Earl A Hubbell, MacDonald S Morris, James L Winkler: Computer-aided engineering system for design of sequence arrays and lithographic masks. Affymax Technologies, Townsend and Townsend and Crew, November 5, 1996: US05571639 (195 worldwide citation)

An improved set of computer tools for forming arrays. According to one aspect of the invention, a computer system (100) is used to select probes and design the layout of an array of DNA or other polymers with certain beneficial characteristics. According to another aspect of the invention, a compute ...


6
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin, Douglas N Modlin: Combinatorial strategies for polymer synthesis. Affymetrix, Banner & Witcoff, March 21, 2000: US06040193 (179 worldwide citation)

An array is created by moving a dispenser toward a solid support until a tip of the dispenser touches the support, withdrawing the tip from the surface and releasing a drop of 5 nanoliters or less in an area smaller than 1 mm.sup.2 to create an array of at least 100 spots.


7
Stephen P A Fodor, Lubert Stryer, James L Winkler, Christopher P Holmes, Dennis W Solas: Photolabile nucleoside and peptide protecting groups. Affymax Technologies, Townsend and Townsend and Crew, February 6, 1996: US05489678 (167 worldwide citation)

A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reacto ...


8
Donald M Besemer, Virginia W Goss, James L Winkler: Apparatus for packaging a chip. Affymetrix, Townsend & Townsend & Crew, August 31, 1999: US05945334 (140 worldwide citation)

A body 300 having a cavity 310 for mounting a chip 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity t ...


9
R Fabian Pease, Glenn McGall, Martin J Goldberg, Richard P Rava, Stephen P A Fodor, Virginia Goss, Lubert Stryer, James L Winkler: Printing oligonucleotide arrays using deprotection agents solely in the vapor phase. Affymetrix, Townsend and Townsend and Crew, November 3, 1998: US05831070 (119 worldwide citation)

A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier material, among ot ...


10
Donald M Besemer, Virginia W Goss, James L Winkler: Method and apparatus for packaging a probe array. Affymetrix, Townsend&Townsend&Crew, October 31, 2000: US06140044 (96 worldwide citation)

A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cav ...