1
Russell N Van Gelder, Mark E Von Zastrow, Jack D Barchas, James H Eberwine: Process for amplifying a target polynucleotide sequence using a single primer-promoter complex. Tracy J Dunn, August 13, 1996: US05545522 (183 worldwide citation)

This invention relates to the use of promoters for ribonucleic acid amplification and other genetic manipulations. Processes are provided wherein complementary deoxyribonucleic acid (cDNA) is synthesized from a ribonucleic acid (RNA) sequence using a complementary primer linked to an RNA polymerase ...


2
Russell N Van Gelder, Mark E Von Zastrow, Jack D Barchas, James H Eberwine: Processes for genetic manipulations using promoters. Board of Trustees of Leland Stanford Junior University, Townsend and Townsend and Crew, February 10, 1998: US05716785 (177 worldwide citation)

This invention relates to the use of promoters for ribonucleic acid amplification and other genetic manipulations. Processes are provided wherein complementary deoxyribonucleic acid (cDNA) is synthesized from a ribonucleic acid (RNA) sequence using a complementary primer linked to an RNA polymerase ...


3
Russell N Van Gelder, Mark E Von Zastrow, Jack D Barchas, James H Eberwine: Processes for genetic manipulations using promoters. Board of Trustees of Leland Stanford University, Arnold White & Durkee, April 6, 1999: US05891636 (153 worldwide citation)

This invention relates to the use of promoters for ribonucleic acid amplification and other genetic manipulations. Processes are provided wherein complementary deoxyribonucleic acid (cDNA) is synthesized from a ribonucleic acid (RNA) sequence using a complementary primer linked to an RNA polymerase ...


4
Mark I Greene, James H Eberwine, Janet Estee Kacharmina, Hongtao Zhang: Method for immuno-detection of epitopes. The Trustees of the University of Pennsylvania, Pepper Hamilton, March 11, 2008: US07341831 (4 worldwide citation)

Methods, systems and kits are provided for detecting, molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific CDR attached to an oligonucleotide.


5
James H Eberwine, Corinne Spencer: Administration of an RNA stem loop structure to modulate protein synthesis. Trustees of the University of Pennsylvania, Law offices of Jane Massey Licata, January 14, 1997: US05593863 (3 worldwide citation)

A method for modulating synthesis of a selected protein in a cell or tissue by contacting the cell or tissue with at least a portion of a mRNA stem loop structure are provided. Compositions containing a mRNA stem loop structure are also provided.


6
Russell N Van Gelder, Mark E Von Zastrow, Jack D Barchas, James H Eberwine: Multi-gene expression profile. Board of Trustees of Leland Stanford University, Barbara J Luther, The Luther Law Firm, May 23, 2006: US07049102

This invention relates to the use of promoters for ribonucleic acid amplification and other genetic manipulations. Processes are provided wherein complementary deoxyribonucleic acid (cDNA) is synthesized from a ribonucleic acid (RNA) sequence using a complementary primer linked to an RNA polymerase ...


7
James H Eberwine, Ulo Langel, Emelia Eiriksdottir, Tina Peritz, Jai Yoon Sul, Philip G Haydon, Junhyong Kim: Methods of detecting transcription. The Trustees of the University of Pennsylvania, Riverside Law, February 16, 2016: US09260703

The present invention includes compositions, methods and kits for the real-time detection of transcription and translation in live cells, tissues and organisms. The present invention further provides method for the rapid sequencing of nucleic acids without using conventional sequencing techniques or ...


8
James H Eberwine, Max B Kelz: In situ cloning from pathological tissue specimens. The Trustees of the Univeristy of Pennsylvania, Riverside Law, September 10, 2013: US08530196

The present invention pertains to methods related to cloning nucleic acids from biological samples, particularly pathological tissue samples. This method includes hybridizing a population of oligonucleotide sequence probes comprising degenerate sequence tags to a fixed tissue, isolating the hybridiz ...


9
James H Eberwine: Methods and kits for identifying and quantifying RNAs and DNAs associated with RNA and DNA binding proteins. Trustees of the University of Pennsylvania, Licata & Tyrrell P C, October 17, 2006: US07122313

Methods and kits for identifying RNAs and DNAs associated with an RNA or DNA binding protein via a detector specific for the binding protein or protein bound thereto which is linked to an oligonucleotide capable of directing the synthesis of cDNA copies of RNA or DNA that are in close proximity to o ...


10
James H Eberwine, Lindy E Barrett: Transcription factors in neuronal dendrites-dendritic protein synthesis and cell death. The Trustees of the University of Pennsylvania, Riverside Law, August 25, 2015: US09114159

The present invention relates to methods of altering the competence of a dendrite and/or the viability of a neuron by modulating the level of Elk-1 in a dendrite. The present invention also provides methods of altering the ATP levels in a neuron, methods of isolating at least one protein of a mitoch ...