1
James F Eggler, Gerald F Holland, Mickael R Johnson, Robert A Volkmann: Hypoglycemic thiazolidinediones. Pfizer, Peter C Richardson, Albert E Frost, Robert K Blackwood, October 27, 1987: US04703052 (53 worldwide citation)

Hypoglycemic 2,3-dihydro-5-benzo[b]furanyl-2,3-dihydro-5-benzo[b]thienyl-, 3,4-dihydro(2H)-6-benzopyranyl- and 6-thiochromanyl-thiazolidine-2,4-diones and pharmaceutically acceptable salts thereof, method for their use in treatment of hyperglycemic animals and pharmaceutical compositions containing ...


2
Anthony Marfat, James F Eggler, Michael J Fray, Kelvin Cooper: Azabenzimidazoles in the treatment of asthma, arthritis and related diseases. Pfizer, Peter C Richardson, Gregg C Benson, Robert T Ronau, June 21, 1994: US05322847 (40 worldwide citation)

A series of imidazo[4,5-c]pyridines which inhibit platelet activating factor (PAF) and also block leukotriene D4 receptors are useful in treating asthma, arthritis, psoriasis, gastrointestinal distress, myocardial infarction, stroke and shock.


3
James F Eggler, Anthony Marfat, Lawrence S Melvin Jr: Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases. Pfizer, Peter C Richardson, J Trevor Lumb, Robert K Blackwood, October 22, 1991: US05059609 (33 worldwide citation)

Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals, pharmaceutical compo ...


4
James F Eggler, Michael R Johnson, Lawrence S Melvin Jr: Bicyclic benzo fused pyran compounds used for nausea treatment and prevention. Pfizer, Peter C Richardson, J Trevor Lumb, Gregg C Benson, September 26, 1989: US04870084 (22 worldwide citation)

Bicyclic fused benzenoid compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, where M is O, CH.sub.2 or NR.sub.6 ; R.sub.6 is hydrogen, formyl, carbobenzyloxy or certain carboalkoxyalkyl, alkanoyl, alkyl, aralkyl or aralkylcarbonyl groups;


5
James F Eggler, Hans Jurgen E Hess: 13,14-Dihydro-15-alkenyl- and 13,14-dihydro-15-alkynyl prostaglandins and analogs thereof. Pfizer, Connolly and Hutz, May 19, 1981: US04268522 (18 worldwide citation)

The invention discloses certain novel 13,14-dihydro-15-alkenyl prostaglandins and 13,14-dihydro-15-alkynyl prostaglandins and analogs of each as well as the novel intermediates employed in their preparation. The 9-oxo compounds of this novel series demonstrate selective bronchodilator activity, cert ...


6
Michael R Johnson, Thomas K Schaaf, Jasjit S Bindra, Hans Jurgen E Hess, James F Eggler: 2-Descarboxy-2-(tetrazol-5-yl)-11-desoxy-15-substituted-.ome ga.-pentanorprostaglandins. Pfizer, Connolly and Hutz, January 13, 1976: US03932389 (13 worldwide citation)

The 2-descarboxy-2-(tetrazol-5-yl)-11-desoxy-15-substituted-.omega.-pentanorpr ostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tis ...


7
James F Eggler, Jasjit S Bindra, Hans Jurgen E Hess: 11-Desoxy-16-aryl-.omega.-tetranorprostaglandins. Pfizer, Connolly and Hutz, October 5, 1976: US03984400 (12 worldwide citation)

11-Desoxy-16-aryl-.omega.-tetranorprostaglandins and various intermediates and processes employed in their preparation are disclosed. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins but they exhibit a greater tissue specifi ...


8
James F Eggler, Gerald F Holland, Michael R Johnson, Robert A Volkmann: Hypoglycemic thiazolidinediones. Pfizer, Peter C Richardson, Albert E Frost, Robert K Blackwood, April 19, 1988: US04738972 (11 worldwide citation)

Hypoglycemic 5-[1-(5,6,7,8-tetrahydro-2-napthyl-; 1,2,3,4-tetrahydro-6-quinolyl-; 2-indanyl-; and 2-indolyl)alkyl]thiazolidine-2,4-dione derivatives, pharmaceutically acceptable salts thereof, and a method for their use in the treatment of hyperglycemic mammals.


9
James F Eggler, Anthony Marfat, Lawrence S Melvin Jr: Substituted tetralins, chromans and related compounds in the treatment and related compounds in the treatment of asthma, arthritis and related diseases. Pfizer, Peter C Richardson, Gregg C Benson, Mervin E Brokke, December 7, 1999: US05998451 (8 worldwide citation)

Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals, pharmaceutical compo ...


10
James F Eggler, Anthony Marfat, Hiroko Masamune, Lawrence S Melvin Jr: Substituted chromans and their use in the treatment of asthma, arthritis and related diseases. Pfizer, Peter C Richardson, Gregg C Benson, A Dean Olson, March 29, 1994: US05298512 (7 worldwide citation)

Substituted chromans which by inhibiting 5-lipoxygenase enzyme are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction, stroke and related disease states in mammals, pharmaceutical compositions thereof, a method of treatment therewith, and to intermed ...