1
Roger N Piasio, James W Ryan, James E Woiszwillo: Reverse sandwich immunoassay. Corning Glass Works, William E Maycock, Clinton S Janes Jr, Clarence R Patty Jr, July 4, 1978: US04098876 (355 worldwide citation)

Method of determining the presence and/or concentration of a polyvalent antigenic substance in a fluid. The method comprises the steps of incubating the fluid with labeled antibodies to the substance to form a first labeled immunochemical complex and then incubating that complex with immobilized ant ...


2
James E Woiszwillo, Larry R Brown, Terrence L Scott, Jie Di, Judith Sudhalter, Charles D Blizzard: Macromolecular microparticles and methods of production and use. Epic Therapeutics, Jones & Askew, July 18, 2000: US06090925 (165 worldwide citation)

Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromol ...


3
James E Woiszwillo, Larry R Brown, Terrence L Scott, Jie Di, Judith Sudhalter, Charles D Blizzard, Frank J Riske: Macromolecular microparticles and methods of production and use. Epic Therapeutics, Jones & Askew, November 9, 1999: US05981719 (145 worldwide citation)

Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromol ...


4
James E Woiszwillo, Larry R Brown, Terrence L Scott, Jie Di, Judith Sudhalter, Charles D Blizzard, Frank J Riske: Macromolecular microparticles and methods of production and use. Epic Therapeutics, Wolf Greenfield & Sacks P C, July 31, 2001: US06268053 (114 worldwide citation)

Methods relating to the field of biochemistry and more specifically relating to microparticles for use in diagnostics, therapeutics, and research are provided.


5
James E Woiszwillo: Macromolecular microparticles and methods of production. Middlesex Sciences, Jones & Askew, November 26, 1996: US05578709 (99 worldwide citation)

A macromolecular microparticle composition formed by dehydrating an aqueous macromolecule solution and crosslinking the dehydrated macromolecules with a crosslinking agent while in a liquid phase or with heat. Preferably, the dehydrating agent is a polymer mixture of polyvinylpyrrolidone and polyeth ...


6
James E Woiszwillo, Jie Di: Method and kit for making a polysaccharide-protein conjugate. Middlesex Sciences, Jones & Askew, September 10, 1996: US05554730 (53 worldwide citation)

A method and kit for making a polysaccharide-protein Schiff base conjugate. A polysaccharide is oxidized with an oxidizing agent and combined with a protein in the presence of a macromolecular crowding agent to form a Schiff base. Preferably, the macromolecular crowding agent is a soluble linear pol ...


7
James E Woiszwillo, Fred Rothstein: Method for isolating biomolecules from a biological sample with linear polymers. Middlesex Sciences, Jones & Askew, February 4, 1997: US05599719 (30 worldwide citation)

A method, composition, and kit for isolating biomolecules from a biological sample wherein the sample is mixed with a soluble, linear polymer, such as polyvinylpyrrolidone, to form a precipitate. The biomolecule of interest is found in the precipitate or is isolated from the supernatant.


8
James E Woiszwillo: Method for isolating biomolecules from a biological sample with linear polymers. Middlesex Sciences, Jones & Askew, June 11, 1996: US05525519 (17 worldwide citation)

A method and composition for isolating biomolecules from a biological sample wherein the sample is mixed with a soluble, linear polymer, such as polyvinylpyrrolidone, to form a precipitate. The biomolecule of interest is found in the precipitate or is isolated from the supernatant.


9
James E Woiszwillo: Ionically formulated biomolecule microcarriers. Sedum Laboratories, Kilpatrick Stockton, November 11, 2003: US06645525 (16 worldwide citation)

Compositions for sustained delivery of a biomolecule including an anionic polymer and a cationic polymer which ironically interact with each other and, optionally, with the biomolecule. Methods for making the compositions, including the step of combining the negatively charged polymer with the posit ...


10
James E Woiszwillo, Larry R Brown, Terrence L Scott, Jie Di, Judith Sudhalter, Charles D Blizzard: Macromolecular microparticles and methods of production and use. Epic Therapeutics, Jones Askew, December 15, 1998: US05849884 (7 worldwide citation)

Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromol ...