1
James E Shapland, Mark B Knudson, Jin Shimada: Drug delivery apparatus and method. CorTrak Medical, Merchant Gould Smith Edell Welter & Schmidt, February 15, 1994: US05286254 (551 worldwide citation)

A drug delivery apparatus and method for delivering a drug locally to internal body tissue. The invention contemplates positioning a drug delivery device in a body passageway or within body tissue and then selectively introducing a selected drug so that it is transported across a drug transport wall ...


2
James E Shapland, Mark B Knudson, Jin Shimada: Phoretic balloon catheter with hydrogel coating. Cortrak Medical, Moore & Hansen, May 13, 1997: US05628730 (390 worldwide citation)

A drug delivery apparatus and method for delivering a drug locally to internal body tissue. The invention contemplates positioning a drug delivery device in a body passageway or within body tissue and then selectively introducing a selected drug so that it is transported across a drug transport wall ...


3
James E Shapland, Mark B Knudson, Jin Shimada, Keith R Hildebrand: Drug delivery apparatus and method. CorTrak Medical, Merchant Gould Smith Edell Welter & Schmidt, February 1, 1994: US05282785 (283 worldwide citation)

A drug delivery apparatus and method for delivering a drug locally to internal body tissue. The invention contemplates positioning a drug delivery device in a body passageway or within body tissue and then selectively introducing a selected drug so that it is transported across a drug transport wall ...


4
James E Shapland, Keith R Hildebrand: Simultaneous cardiac pacing and local drug delivery method. CorTrak Medical, Merchant Gould Smith Edell Welter & Schmidt PA, June 3, 1997: US05634899 (274 worldwide citation)

An apparatus and method for delivering a drug selectively and locally to internal body tissue with a catheter using electric current/voltage controlled in conjunction with active pacing of cardiac activity.


5
Joel R Racchini, James E Shapland, Mark B Knudson, Jin Shimada, Keith R Hildebrand: Porous balloon for selective dilatation and drug delivery. CorTrak Medical, Merchant Gould Smith Edell Welter & Schmidt, October 17, 1995: US05458568 (273 worldwide citation)

A drug delivery apparatus and method for delivering a drug locally to internal body tissue. The invention contemplates positioning a drug delivery device in a body passageway or within body tissue and then selectively wetting a membrane within the device, making the membrane permeable and allowing t ...


6
James E Shapland, Keith R Hildebrand: Simultaneous cardiac pacing and local drug delivery. Cortrak Medical, Merchant Gould Smith Edell Welter & Schmidt P A, February 2, 1999: US05865787 (215 worldwide citation)

An apparatus and method for delivering a drug selectively and locally to internal body tissue with a catheter using electric current/voltage controlled in conjunction with active pacing of cardiac activity.


7
James E Shapland, Keith R Hildebrandt, Mark B Knudson: Method for iontophoretically delivering drug adjacent to a heart. Cortrak Medical, Merchant Gould Smith Edell Welter & Schmidt, March 19, 1996: US05499971 (197 worldwide citation)

A drug delivery apparatus and method for iontophoretically delivering a drug locally to internal body tissue. The iontophoretic delivery apparatus and method include a current source producing a net flow of current in a desired direction with high frequency waveforms which enhance delivery and minim ...


8
James E Shapland, Mark B Knudson, Jin Shimada, Joel R Racchini: Simultaneous angioplasty and phoretic drug delivery. CorTrak Medical, Merchant Gould Smith Edell Welter & Schmidt, March 12, 1996: US05498238 (185 worldwide citation)

A method of simultaneous angioplasty and drug delivery to a localized portion of coronary or peripheral arteries or any other type of body passage that has a stricture. The invention contemplates positioning a drug delivery device in a body passageway and then selectively introducing a selected drug ...


9
Jin Shimada, James E Shapland: Drug delivery by multiple frequency phonophoresis. Trancell, Merchant Gould Smith Edell Welter & Schmidt, December 7, 1993: US05267985 (167 worldwide citation)

The present invention provides a method and apparatus for enhancing the diffusion of a substance to a local area of material or tissue by providing ultrasonic energy to the substance and material in two or more distinct frequencies simultaneously. Each of the distinct frequencies of ultrasonic energ ...


10
Mark B Knudson, James E Shapland: Invasive FTIR blood constituent testing. Inomet, Merchant Gould Smith Edell Welter & Schmidt, January 7, 1992: US05079421 (37 worldwide citation)

An apparatus is disclosed for measuring a blood constituent. In a preferred embodiment, the apparatus includes a semipermeable membrane for defining a volume with a flexible membrane disposed on one end and with a light source disposed on an opposite end. The flexible membrane flexes to become the m ...



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