1
James E Brown, Wouter E Roorda: Directional drug delivery stent and method of use. Alza Corporation, Burns Doane Swecker & Mathis L, June 6, 2000: US06071305 (465 worldwide citation)

The invention relates to a directional drug delivery stent which includes an elongated or tubular member having a cavity containing a biologically active agent. In one embodiment, the active agent is diffused from the reservoir directly to the walls of a body lumen, such as a blood vessel, through d ...


2
Wouter E Roorda, Keith E Dionne, James E Brown, Jeremy C Wright, Craig R Davis, Steven J Prestrelski, Stelios T Tzannis: Diffusional implantable delivery system. ALZA Corporation, Burns Doane Swecker & Mathis L, October 26, 1999: US05972369 (83 worldwide citation)

A sustained release delivery system for delivering a beneficial agent is provided. The system includes a reservoir comprising the beneficial agent and a capillary channel in communication with the reservoir and the exterior of the system for delivering the beneficial agent from the system. The capil ...


3
Juan C Gumucio, Keith E Dionne, James E Brown: Self adjustable exit port. ALZA Corporation, Burns Doane Swecker & Mathis L, December 7, 1999: US05997527 (53 worldwide citation)

A delivery device having a first chamber containing an osmotic agent, a membrane forming a wall of the first chamber through which fluid is imbibed by osmosis, a second chamber containing a beneficial agent to be delivered, and a moveable piston separating the two chambers. In fluid communication wi ...


4
John R Peery, Scott J Gilbert, James E Brown: Osmotic implant with membrane and membrane retention means. ALZA Corporation, January 16, 2007: US07163688 (37 worldwide citation)

An osmotic delivery system for controlled delivery of a beneficial agent includes an implantable capsule containing a beneficial agent and an osmotic engine that swells on contact with water, thereby causing the release of the beneficial agent over time. The osmotic delivery system has a membrane ma ...


5
Gary R Muller, Scott M Theiss, James E Brown Jr, Bobby R Lawson: Nuclear steam generator sludge lancing method and apparatus. Apex Technologies, Sughrue Mion Zinn Macpeak & Seas, December 29, 1987: US04715324 (29 worldwide citation)

A method and apparatus for removing from the tube sheet and transfer tubes of a nuclear steam generator sludge deposits which occur from the use of all volatile treatment water chemistry. A continuously activated suction apparatus maintains at a low level the water/sludge inventory on the tube sheet ...


6
Juan C Gumucio, Keith E Dionne, James E Brown: Self adjustable exit port. ALZA Corporation, Pauline A Clarke, Robert G Mukai, Steven F Stone, April 17, 2001: US06217906 (27 worldwide citation)

A delivery device having a first chamber containing an osmotic agent, a membrane forming a wall of the first chamber through which fluid is imbibed by osmosis, a second chamber containing a beneficial agent to be delivered, and a moveable piston separating the two chambers. In fluid communication wi ...


7
Felix Theeuwes, James E Brown: Regulation of drug delivery through flow diversion. Durect Corporation, Carol L Francis, Adam Bell, Bozicevic Field & Francis, October 28, 2003: US06638263 (23 worldwide citation)

The present invention features methods and devices for modulating the rate of delivery of a drug formulation from a drug delivery device by diverting drug away from a drug delivery pathway. In one embodiment, a flow regulator is positioned relative to a drug delivery pathway of a drug delivery syste ...


8
James E Brown, Cynthia A Cowgill: Phospholipid affinity purification of Factor VIII:C. Miles Laboratories, David J Aston, Pamela A Simonton, January 3, 1989: US04795806 (17 worldwide citation)

Affinity purification of Factor VIII:C, both plasma derived and genetically engineered, using coupled phosphatidylserine (PS) as the predominant phospholipid (PH) results in a high degree of purity of Factor VIII:C, similar to that previously demonstrated with monoclonal antibodies specific to eithe ...


9
Jehu R Bell, Dean W Hazelton, James E Brown, Gene E Dodson, Gary W Harter: Ultrasonic cutting system for stock material. General Tire, Calfee Halter & Griswold, November 30, 1993: US05265508 (11 worldwide citation)

An ultrasonic cutting system for stock material temporarily bonds the stock material to an anvil incorporated in a processing table and cuts the stock material at a low angle with an ultrasonic cutting tool. The ultrasonic cutting tool is mounted on a carriage assembly which traverses the width of t ...


10
James E Brown, Jeffrey R Simons: Gripper assembly for a conveying device for conveying single-sheet or multi-sheet printed products and a method for modifying the same. Philadelphia Newspapers, Dechert, May 8, 2001: US06227589 (6 worldwide citation)

A gripper assembly for a conveying device for conveying printed products. More particularly, a gripper assembly having: (a) a first gripper part, having a clamping surface and an external surface; (b) a second gripper part, having a clamping surface and an external surface; wherein the first gripper ...



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