1
Tarran Jones
Robert W Chestnut, Margaret J Polley, James C Paulson, S Tarran Jones, Jose W Saldanha, Mary M Bendig, Michael Kriegler, Carl Perez, Robert Bayer, Michael Nunn: Antibodies to P-selectin and their uses. Cytel Corporation, Campbell & Flores, September 1, 1998: US05800815 (24 worldwide citation)

The present invention relates to compositions and methods for treating inflammation and other pathological conditions using novel blocking P-selectin antibodies that inhibit adhesion of leukocytes to activated platelets and/or to activated vascular endothelium in vivo. Both murine and humanized anti ...


2
Tarran Jones
Robert W Chesnut, Margaret J Polley, James C Paulson, S Tarran Jones, Jose W Saldanha, Mary M Bendig, Michael Kriegler, Carl Perez, Robert Bayer, Michael Nunn: Method for detecting the presence of P-selectin. Cytel Corporation, Campbell & Flores, March 7, 2000: US06033667 (4 worldwide citation)

The present invention relates to compositions and methods for treating inflammation and other pathological conditions using novel blocking P-selectin antibodies that inhibit adhesion of leukocytes to activated platelets and/or to activated vascular endothelium in vivo. Both murine and humanized anti ...


3
James C Paulson, Eryn Ujita Lee, Karen J Colley, Beverly Adler, Jeffrey K Browne: Method for producing secretable glycosyltransferases and other Golgi processing enzymes. The Regents of the Univ of California, Poms Smith Lande & Rose, July 16, 1991: US05032519 (93 worldwide citation)

A method for genetically engineering cells to produce soluble and secretable Golgi processing enzymes instead of naturally occurring membrane-bound enzymes. Cells are genetically engineered to express glycosyltransferases which lack both a membrane anchor and a r


4
James C Paulson, Xiaohong Wen, Brian Livingston, William Gillespie, Sorge Kelm, Alma L Burlingame, Katalin Medzihradszky: Compositions and methods for the identification and synthesis of sialyltransferases. The Regents of the University of California, Amgen, Oppenheimer Wolff & Donnelly, October 5, 1999: US05962294 (57 worldwide citation)

DNA isolates coding for sialyltransferase which contain a conserved region of homology and methods of obtaining such DNA are provided, together with expression systems for recombinant production of sialyltransferase.


5
James C Paulson, Xiaohong Wen, Brian Livingston, Alma L Burlingame, Katalin Medzihradszky, Sorge Kelm, William Gillespie: Compositions and methods for producing sialyltransferases. The Regents of the University of California, Oppenheimer Wolff & Donnelly, January 12, 1999: US05858751 (43 worldwide citation)

DNA isolates coding for sialyltransferase which contain a conserved region of homology and methods of obtaining such DNA are provided, together with expression systems for recombinant production of the various sialyltransferases.


6
James C Paulson, Robert J Bayer, Eric Sjoberg: Practical in vitro sialylation of recombinant glycoproteins. Neose Technologies, Townsend and Townsend and Crew, June 4, 2002: US06399336 (42 worldwide citation)

This invention provides methods for practical in vitro sialylation of glycoproteins, including recombinantly produced glycoproteins. The methods are useful for large-scale modification of sialylation patterns.


7
James C Paulson, Mary S Perez, Federico C A Gaeta, Robert M Ratcliffe: Intercellular adhesion mediators. Cytel Corporation, Townsend and Townsend and Crew, May 19, 1998: US05753631 (39 worldwide citation)

The present invention is directed towards compositions and methods for reducing or controlling inflammation and for treating inflammatory disease processes and other pathological conditions mediated by intercellular adhesion. The compositions of the invention include compounds that selectively bind ...


8
Yukishige Ito, James C Paulson: Use of trans-sialidase and sialyltransferase for synthesis of sialyl.alpha.2.fwdarw.3.beta.galactosides. Cytel, Welsh & Katz, April 25, 1995: US05409817 (25 worldwide citation)

A single vessel cyclic synthesis process for preparation of a sialyl.alpha.2.fwdarw.3.beta.galactoside is disclosed. In accordance with this process, a sialyltransferase acceptor is sialylated in an aqueous reaction medium by an .alpha.(2,3)sialyl transferase and CMP-sialic acid to form a sialyl don ...


9
Reiko F Irie, Tadashi Tai, Donald L Morton, Leslie D Cahan, James C Paulson: Antigenic compositions and methods for using same. Regents of the University of California, Poms Smith Lande & Rose, December 10, 1985: US04557931 (24 worldwide citation)

GM2 is a ganglioside present on the surface of tumors and stimulates an appreciable immune response in mammals. It is useful when coupled with a non-toxic protein carrier or mixed with an adjuvent and injected parenterally of raising the anti-GM2 titer in serum. GM2 is also valuable as a diagnostic ...


10
James C Paulson, Robert D Pfeifer: Diagnostic evaluation, measurement, and analysis of functional activity in body organs that utilize transmembrane ion polarization and depolarization. Julian Caplan, December 29, 1981: US04307726 (11 worldwide citation)

Beams of coherent microwaves or other frequencies of highly directional electromagnetic radiation are passed through the living human body to detect and provide a quantitative analysis of functional activity in the central nervous system and/or in muscle tissue such as that of the heart. Organs to b ...