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Kucherlapati Raju, Jakobovits Aya: Generation of xenogeneic antibodies.. Cell Genesys, January 2, 1992: EP0463151-A1 (119 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci. The hosts are produced by repetitive transformations of embryonic stem cells by homologous recombination, preferably in conjunction with breeding. Different strategies are employed for recombina ...


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Kucherlapati Raju, Jakobovits Aya, Klapholz Sue, Brenner Daniel G, Capon Daniel J: Human antibodies derived from immunized xenomice. Abgenix, GUNNISON Jane T, October 31, 1996: WO/1996/033735 (14 worldwide citation)

Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed ...


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Kucherlapati Raju, Jakobovits Aya: Generation of xenogeneic antibodies. Cell Genesys, May 8, 1996: EP0710719-A1 (12 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by repetitive transformations of embryonic stem cells by homologou ...


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Raitano Arthur B, Morrison Robert Rendall, Morrison Karen Jane Mayrick, Kanmer Steven B, Challita Eid Pia M, Jia Xiao Chi, Gudas Jean, Jakobovits Aya: Antibodies and related molecules that bind to 24p4c12 proteins. Agensys, Raitano Arthur B, Morrison Robert Rendall, Morrison Karen Jane Mayrick, Kanmer Steven B, Challita Eid Pia M, Jia Xiao Chi, Gudas Jean, Jakobovits Aya, MURASHIGE Kate H, March 12, 2009: WO/2009/033094 (11 worldwide citation)

Antibodies and molecules derived therefrom that bind to 24P4C12 protein and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognosti ...


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Jakobovits Aya, Kucherlapati Raju, Klapholz Sue, Mendez Michael, Green Larry: (k) Regions and antibodies produced therefrom. Abgenix, HALEY James F Jr, June 11, 1998: WO/1998/024893 (10 worldwide citation)

The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (V¿H? and V$g(k)) gene regions. Advantageously, the inclusion of plu ...


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Raitano Arthur B, Challita Eid Pia M, Ge Wangmao, Perez Villar Juan J, Kanner Steven B, Jakobovits Aya: Nucleic acids and corresponding proteins entitled 109p1d4 useful in treatment and detection of cancer. Agensys, Raitano Arthur B, Challita Eid Pia M, Ge Wangmao, Perez Villar Juan J, Kanner Steven B, Jakobovits Aya, DEVERNOE David L, November 18, 2004: WO/2004/098515 (9 worldwide citation)

A novel gene 109P1D4 and its encoded protein, and variants thereof, are described wherein 109P1D4 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table i. Consequently, 109P1D4 provides a diagnostic, prognostic, prophylactic and/or the ...


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Kuncherlapati Raju, Jakobovits Aya, Klapholz Sue, Brenner Daniel G, Capon Daniel J: Generation of xenogeneic antibodies. Cell Genesys, BENZ William H, February 3, 1994: WO/1994/002602 (9 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...


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Dennis Mark S, Rubinfeld Bonnee, Polakis Paul, Jakobovits Aya: Antibodies and immunoconjugates and uses therefor. Genentech, Dennis Mark S, Rubinfeld Bonnee, Polakis Paul, Jakobovits Aya, DREGER Ginger R, May 2, 2008: WO/2008/052187 (8 worldwide citation)

Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.


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Kucherlapati Raju, Jakobovits Aya, Klapholz Sue, Brenner Daniel G, Capon Daniel J: Human antibodies derived from immunized xenomice. Abgenix, GUNNISON Jane T, October 31, 1996: WO/1996/034096 (8 worldwide citation)

Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipula ...