1
J Richard Spears, Donna Bourgelais: Method and apparatus for angioplasty. The Beth Israel Hospital, Lorusso & Loud, May 28, 1991: US05019075 (492 worldwide citation)

The region surrounding the balloon utilized in percutaneous transluminal coronary angioplasty is heated by means within the balloon or within the skin of the balloon upon inflation of the balloon such that disrupted tissues of the plaque in the arterial wall are heated in order to fuse together frag ...


2
J Richard Spears: Method and apparatus for angioplasty. The Beth Israel Hospital Association, Lorusso & Loud, January 24, 1989: US04799479 (386 worldwide citation)

The region surrounding the balloon utilized in percutaneous transluminal coronary angioplasty is heated by means within the balloon or within the skin of the balloon upon inflation of the balloon such that disrupted tissues of the plaque in the arterial wall are heated in order to fuse together frag ...


3
Edward L Sinofsky, J Richard Spears, Douglas W Dickinson, Maria S Wagner: Laser balloon catheter. C R Bard, Wolf Greenfield & Sacks, November 7, 1989: US04878492 (136 worldwide citation)

A laser balloon catheter intended primarily for coronary angioplasty includes a flexible tube having an inflatable balloon secured to its distal end, a central shaft within the balloon for carrying a guide wire, an optical fiber for carrying laser radiation through the flexible tube into the balloon ...


4
J Richard Spears, Donna Bourgelais: Method for angioplasty. The Beth Israel Hospital, Lorusso & Loud, July 13, 1993: US05226430 (117 worldwide citation)

The region surrounding the balloon utilized in percutaneous transluminal coronary angioplasty is heated by means within the balloon or within the skin of the balloon upon inflation of the balloon such that disrupted tissues of the plaque in the arterial wall are heated in order to fuse together frag ...


5
J Richard Spears: Method of treatment of artherosclerosis and balloon catheter the same. The Beth Israel Hospital Association, Lorusso & Loud, September 27, 1988: US04773899 (115 worldwide citation)

A method for the treatment of atherosclerosis in a mammal by destruction of atheromatous plaque is disclosed. The disclosed method includes injecting a hematoporphyrin into the mammal for selective uptake into the atheromatous plaque, and delivering light to the diseased vessel so that the light act ...


6
J Richard Spears: Method for diagnosis of atherosclerosis. The Beth Israel Hospital Association, Pahl Lorusso & Loud, March 25, 1986: US04577636 (79 worldwide citation)

Method for diagnosis of the presence of atherosclerosis plaques. The method comprises injection of a hematoporphyrin which is selectively absorbed by atheromotous plaques. The hematoporphyrin is then subjected to light causing it to fluorese and the fluorescence is used to diagnose the presence of t ...


7
J Richard Spears, Philip S Levin, Paul J Zalesky: High pressure perfusion device. Therox, Wayne State University, Pennie & Edmonds, August 25, 1998: US05797876 (75 worldwide citation)

The present invention includes a guidewire device capable of delivering perfusion fluids to a vascular site while at the same time exhibiting handling characteristics associated with existing non-perfusion guidewires. Preferred embodiments include a perfusion guidewire which closely matches the dime ...


8
J Richard Spears, Philip S Levin, Paul J Zalesky, Vincent Divino Jr: High pressure transluminal fluid delivery device. TherOx, Pennie & Edmonds, September 28, 1999: US05957899 (65 worldwide citation)

The present invention includes a fluid delivery device capable of delivering perfusion or other fluids to a vascular site. Preferred embodiments permit delivery of large quantities of fluid without causing recoil of the device, and without causing trauma to the vascular site.


9
J Richard Spears, Philip S Levin, Paul J Zalesky, Vincent Divino Jr: Angioscopy apparatus and methods. Therox, Wayne State University, Fletcher Yoder & Van Someren, September 26, 2000: US06123698 (63 worldwide citation)

The present invention includes a fluid delivery device capable of delivering perfusion or other fluids to a vascular site. Preferred embodiments permit delivery of large quantities of fluid without causing recoil of the device, and without causing trauma to the vascular site.


10
J Richard Spears, Richard Crilly, Ray Rydman, James Gessert, Steve Myrick: Apparatus for oxygenating wastewater. Wayne State University, TherOx, DynamOx, Margaret A Kivinski, March 7, 2006: US07008535 (54 worldwide citation)

A method and apparatus creates gas-enriched fluid that is used to treat wastewater. In one embodiment, the wastewater is withdrawn from a supply of wastewater to be treated, and the wastewater is delivered in an atomized manner to a vessel pressurized with gas to form gas-enriched wastewater. The ga ...