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Kiyoto Sumio, Nishikawa Motoaki, Iwami Morita, Terano Hiroshi, Kohsaka Masanobu, Imanaka Hiroshi: Biologically active ws 6049 substances, a process for the production thereof and their pharmaceutical compositions.. Fujisawa Pharmaceutical Co, November 30, 1983: EP0095154-A1 (64 worldwide citation)

Biologically active WS 6049 substances obtainable by culturing a strain belonging to the genus Actinomadura in an aqueous nutrient medium under aerobic conditions and recovering WS 6049-A substance and/or WS 6049-B substance. The invention also relates to a process for preparing the new substances a ...


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Isogai Takao, Fukagawa Masao, Iwami Morita, Aramori Ichiro, Kojo Hitoshi: Process for producing 7-aminocephem compound or salts thereof.. Fujisawa Pharmaceutical Co, July 10, 1991: EP0436355-A2 (9 worldwide citation)

A process for producing 7-aminocephem compounds, or salts thereof, which comprises cultivating in a nutrient medium a microorganism capable of producing a 7-aminocephem compound of the formula: wherein R is acetoxy, hydroxy or hydrogen, and recovering the compound (I) or a salt thereof from the cult ...


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Okamoto Masanori, Iwami Morita, Takase Shigehiro, Uchida Itsuo, Umehara Kazuyoshi, Kohsaka Masanobu, Imanaka Hiroshi No Sakurai: New nitro aliphatic compounds, process for preparation thereof and use thereof.. Fujisawa Pharmaceutical Co, July 11, 1984: EP0113106-A1 (8 worldwide citation)

A compound of the formula or its pharmaceutically acceptable salt: wherein R is hydrogen, lower alkyl or lower alkoxylphenyl, R is hydrogen or lower alkyl, R and R are each hydrogen, or together to form a bond for getting a group of the formula: wherein R and R are each as defined below, R is lower ...


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Iwami Morita, Aramori Ichiro, Fukagawa Masao, Isogai Takao, Kojo Hitoshi: Cephalosporin c acylase.. Fujisawa Pharmaceutical Co, March 18, 1992: EP0475652-A2 (8 worldwide citation)

A cephalosporin C acylase with the following characteristics: (a) has ability to catalyze the enzymatic conversion of cephalosporin C, glutaryl 7-ACA, adipyl 7-ACA, succinyl 7-ACA, N-acetylcephalosporin C, N-benzoylcephalosporin C and cephalothin into 7-amino cephalosporanic acid, (b) is composed of ...


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Aramori Ichiro, Fukagawa Masao, Ono Hiroki, Ishitani Yosuke, Tsumura Mana, Iwami Morita, Kojo Hitoshi: Gl-7aca acylase.. Fujisawa Pharmaceutical Co, April 29, 1992: EP0482844-A2 (3 worldwide citation)

A GL-7ACA acylase having the following characteristics: (a) has ability to catalyze the enzymatic conversion of glutaryl 7-ACA, adipyl 7-ACA, and succinyl 7-ACA, into 7-aminocephalosporanic acid, (b) has a molecular weight of 70,000 dalton (SDS-PAGE) and (c) has N-terminal amino acid sequence thereo ...


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Nishikawa Motoaki, Iwami Morita, Yoshida Keizo, Kohsaka Masanobu: Ws 7739 substances, their preparation and pharmaceutical composition containing the same.. Fujisawa Pharmaceutical Co, May 22, 1985: EP0142121-A2 (2 worldwide citation)

New biologically active substances - called WS 7739 - having pharmacological activity are prepared by fermentation of a strain belonging to the genus Streptomyces, e.g. Streptomyces phaeofaciens subsp. matsuenensis no. 7739 FERM BP 660 in a nutrient medium containing sources of assimilable carbon an ...


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KATO SACHI , MATSUMOTO YOSHIMI , NAOKI HIDEO , IWAMI MORITA : [de] NEUARTIGES MIKROBIELLES PRODUKT MIT ANTIMYKOTISCHER WIRKUNG, [en] NOVEL MICROBIAL PRODUCT HAVING ANTIFUNGAL ACTIVITY, [fr] NOUVEAU PRODUIT MICROBIEN AYANT UNE ACTIVITÉ ANTIFONGIQUE. SEED RES INST  , OP BIO FACTORY  , July 6, 2016: EP3040338-A1 (1 worldwide citation)

[en] Provided are a compound having a novel mother nucleus, which can be a promising drug discovery seed compound, use thereof as an antifungal agent, and a production method thereof and the like. A compound represented by the following formula: or a pharmaceutically acceptable salt thereof, and an ...


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ISHIKAWA AKIHIKO , IWAMI MORITA : [de] OXAZIRIDINE VERBINDUNG UND DEREN HERSTELLUNG, [en] OXAZIRIDINE COMPOUND AND PRODUCTION METHOD THEREOF, [fr] COMPOSÉ DUN OXAZIRIDINE ET ET SON PROCÉDÉ DE PRODUCTION. SEED RES INST  , November 15, 2017: EP3243825-A1

[en] Provided are an oxaziridine compound showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, and a production method thereof. A compound represented by the formula 1: wherein X is a single bond, -C(H)(R 6 )- or -C(H)(R 7 )-C(H)(R 8 )-; and R 1 ...


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Kohsaka Masanobu, Takase Shigehiro, Uchida Itsuo, Terano Hiroshi, Iwami Morita, Hashimoto Masashi, Yamashita Michio, Komori Tadaaki: Composes tetracycliques; leur preparation et composition pharmaceutique qui en renferme, Tetracyclo compounds, a process for their production and a pharmaceutical composition containing the same. Fujisawa Pharmaceutical, OGILVY RENAULT SENCRLSRL, January 17, 1989: CA1248897

Abstract1. Title of Invention: NEW TETRACYCLO COMPOUNDS, A PROCESS FOR THEIRPRODUCTION AND A PHARMACEUTICAL COMPOSITIONCONTAINING THE SAME2. New tetracyclo compounds of the formula : Image (I)in which R1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl,arylaminomethyl, carboxy, pr ...