1
Ivan Osorio, Mark G Frei: Vagal nerve stimulation techniques for treatment of epileptic seizures. Banner & Witcoff, January 22, 2002: US06341236 (588 worldwide citation)

A system and method for using electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vag ...


2
Josef Dorfmeister, Mark Frei, David Lerner, Ivan Osorio, John Ralston: System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject. University of Kansas, Donald R Schoonover, November 30, 1999: US05995868 (361 worldwide citation)

A system (10) analyzes signals representative of a subject's brain activity in a signal processor (12) for information indicating the subject's current activity state and for predicting a change in the activity state. One preferred embodiment uses a combination of nonlinear filtering methods to perf ...


3
Ivan Osorio, Mark G Frei: Vagal nerve stimulation techniques for treatment of epileptic seizures. Banner & Witcoff, December 30, 2003: US06671556 (334 worldwide citation)

The present invention uses electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus ...


4
Ivan Osorio, Mark G Frei: Vagal nerve stimulation techniques for treatment of epileptic seizures. Banner & Witcoff, July 1, 2003: US06587727 (237 worldwide citation)

The present invention uses electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus ...


5

6
Ivan Osorio, Naresh C Bhavaraju: Stimulation methodologies and apparatus for control of brain states. Flint Hills Scientific L L C, Donald R Schonover, August 23, 2005: US06934580 (189 worldwide citation)

A system of accessing the brain of a subject to record and/or stimulate brain stares thereof. The system includes control means, first accessing means having a plurality of contact surfaces configured to operatively connect the control means to the brain of the subject to provide three-dimensional s ...


7
Mark G Frei, Ivan Osorio, Mark T Rise, Jonathon E Giftakis, Nina M Graves, David L Carlson, Randy M Jensen: Channel-selective blanking for a medical device system. Medtronic, Banner & Witcoff, July 10, 2007: US07242983 (177 worldwide citation)

Apparatuses and methods selectively blank a neurological channel of a medical device system in the treatment of a nervous system disorder. A selected signal of a selected channel may be blanked if it is determined that the selected signal may be affected by an artifact when the medical device system ...


8
Ivan Osorio, Mark G Frei: Vagal nerve stimulation techniques for treatment of epileptic seizures. Donald R Schoonover, July 19, 2005: US06920357 (166 worldwide citation)

The present invention uses electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus ...


9
Ivan Osorio, Naresh C Bhavaraju: Unitized electrode with three-dimensional multi-site, multi-modal capabilities for detection and control of brain state changes. Flint Hills Scientific L L C, Donald R Schoonover, February 28, 2006: US07006859 (165 worldwide citation)

An electrode with three-dimensional capabilities for detection and control of brain state changes of a subject. The electrode includes a disk portion having an upper surface and a lower surface, and a shaft portion secured to and extending perpendicularly outwardly from the lower surface of the disk ...


10
Ivan Osorio, Mark G Frei: Vagal nerve stimulation techniques for treatment of epileptic seizures. Flint Hills Scientific L L C, Donald R Schoonover, November 1, 2005: US06961618 (163 worldwide citation)

The present invention uses electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus ...