1
Matsuo Takashi, Itaya Nobushige, Okuno Yositosi, Mizutani Toshio, Ohno Nobuo, Kitamura Shigeyoshi: Alpha-cyanobenzyl cyclopropanecarboxylates. Sumitomo Chemical Company, Stevens Davis Miller & Mosher, September 10, 1974: US3835176 (112 worldwide citation)

.alpha.-Cyanobenzyl cyclopropanecarboxylates of the formula, ##SPC1##Wherein A is oxygen atom or methylene group, R.sub.1 and R.sub.2 are respectively hydrogen atom, a halogen atom or a lower alkyl group, R.sub.3 is hydrogen atom or methyl group, R.sub.4 is hydrogen atom, methyl group, phenyl group ...


2
Itaya Nobushige, Kamoshita Katsuzo, Mizutani Toshio, Kitamura Shigeyoshi, Nakai Shinji, Kameda Nobuyuki, Fujimoto Keimi, Okuno Yositosi: Cyclopropanecarboxylic acid esters. Sumitomo Chemical Company, May 30, 1972: US3666789 (52 worldwide citation)

Novel cyclopropanecarboxylic acid esters having an excellent insecticidal activity and harmless property to mammals and cattles, of the formulawherein Y is oxygen or sulfur atom, R.sub.1 is hydrogen atom or methyl group, R.sub.2 is methyl, 2-methyl-1-propenyl, 2-methoxycarbonyl-1-propenyl, phenyl or ...


3
Sugi Kiyoshi, Itaya Nobushige, Katsura Tadashi, Igi Masami, Yamazaki Shigeya, Ishibashi Taro, Yamaoka Teiji, Kawada Yoshihiro, Tagami Yayoi: Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation. Sumika Fine Chemicals, December 17, 1997: EP0812827-A1 (22 worldwide citation)

A piperidine derivative, which can be used as an intermediate for pharmaceuticals such as paroxetine useful as antidepressants, represented by the general formula (I): wherein R is hydrogen atom, benzyloxycarbonyl group or tert-butoxycarbonyl group; R is hydroxymethyl group, an alkylsulfonyloxymethy ...


4
Mizutani Toshio, Itaya Nobushige, Ohno Nobuo, Matsuo Takashi, Kitamura Shigeyoshi, Okuno Yositosi: Cyclopropanecarboxylates. Sumitomo Chemical Company, Craig & Antonelli, January 21, 1975: US3862174 (12 worldwide citation)

A cyclopropanecarboxylate of the formula: ##SPC1##Wherein R.sub.1 is methyl, R.sub.2 is lower alkoxymethyl, lower alkenoxymethyl, lower alkynoxymethyl or acyl such as lower alkanoyl, lower alkenylcarbonyl or lower alkynylcarbonyl or, when taken together with the adjacent carbon atom, R.sub.1 and R.s ...


5
Okuno Yoshitoshi, Itaya Nobushige, Mizutani Toshio: Novel cyclopropanecarboxylate. Sumitomo Chemical Company, Stevens Davis Miller & Mosher, April 8, 1975: US3876681 (11 worldwide citation)

A compound of the formula, ##SPC1##Wherein R is hydrogen or methyl group, which is harmless to warm-blooded animals, useful as an active ingredient of insecticides, particularly in the form of fumigant, and prepared by reacting a compound of the formula, ##SPC2##With a compound of the formula, ##SPC ...


6
Miyamoto Hideto, Sugi Kiyoshi, Itaya Nobushige: Production of sertraline hydrochloride. Sumika Fine Chemicals, January 25, 2000: JP2000-026378 (11 worldwide citation)

PROBLEM TO BE SOLVED: To obtain a sertraline hydrochloride having excellent solubility in various solvents and bioavailability and a crystal structure of metastable form by dissolving a sertraline free base in a solvent or suspending a sertraline organic acid salt in a solvent and introducing hydroc ...


7
Itaya Nobushige, Mizutani Toshio, Kitamura Shigeyoshi, Okuno Yositosi, Fujimoto Keimei: 5-propargylthenyl cyclopropanecarboxylates. Sumitomo Chemical Company, June 20, 1972: US3671548 (9 worldwide citation)

A thiophene derivative having the formula, ##SPC1##Wherein R.sub.1 is hydrogen or methyl, and R.sub.2 is methyl, 2-methyl-1-propenyl or 2-methoxycarbonyl-1-propenyl when R.sub.1 is hydrogen, and R.sub.2 is methyl when R.sub.1 is methyl, which may be used as insecticides with high insecticidal activi ...


8
Ueda Kenzo, Mizutani Toshio, Itaya Nobushige, Okuno Yositosi: Certain substituted chrysanthemates as insecticides. Sumitomo Chemical Company, Stevens Davis Miller & Mosher, February 18, 1975: US3867542 (9 worldwide citation)

A compound of the formula, ##SPC1##Wherein R.sub.1 is a methyl, R.sub.2 is a C.sub.1 -C.sub.5 alkoxymethyl, a C.sub.3 -C.sub.5 alkenoxymethyl, a C.sub.3 -C.sub.5 alkynoxymethyl, a C.sub.1 -C.sub.5 alkylcarboxyl, a C.sub.2 -C.sub.5 alkenylcarbonyl or a C.sub.2 -C.sub.5 alkynylcarbonyl, or R.sub.1 and ...


9
Ohno Nobuo, Itaya Nobushige, Mizutani Toshio, Okuno Yositosi, Fujimoto Keimei, Kawanami Toru: Certain furylmethyl and thenyl esters of certain cyclopropane carboxylic acids. Sumitomo Chemical Company, Stevens Davis Miller & Mosher, December 31, 1974: US3857863 (7 worldwide citation)

A cyclopropanecarboxylate represented by the formula, ##SPC1##Wherein R.sub.1 is hydrogen atom, methyl or ethyl group, R.sub.2 is methyl, ethyl, 2-methyl-1-propenyl or 2-methoxycarbonyl-1-propenyl group when R.sub.1 is hydrogen atom, or R.sub.2 is methyl or ethyl group when R.sub.1 is methyl or ethy ...


10
Miyamoto Hideto, Sugi Kiyoshi, Itaya Nobushige: Sertraline hydrochloride methanolated substance and sertraline hydrochloride ethanolated substance and their production. Sumika Fine Chemicals, January 25, 2000: JP2000-026379 (7 worldwide citation)

PROBLEM TO BE SOLVED: To obtain sertraline hydrochloride crystal useful as an antidepressant and to provide a method for industrially producing sertraline hydrochloride crystal. SOLUTION: (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1- naphthylamine hydrochloride methanolated substance ...