1
Irving J Higgins, Hugh A O Hill, Elliot V Plotkin: Sensor for components of a liquid mixture. Genetics International, October 8, 1985: US04545382 (760 worldwide citation)

A sensor electrode to detect one or more components in a liquid mixture comprises an electrically conductive material having at least an an external surface, the combination of an enzyme catalytic for a reaction of the desired component, and a mediator compound which transfers electrons from the enz ...


2
Hugh A O Hill, Irving J Higgins, James M McCann, Graham Davis: Strip electrode including screen printing of a single layer. MediSense, Fish & Richardson, April 23, 1996: US05509410 (736 worldwide citation)

A sensor system that detects a current representative of a compound in a liquid mixture features a two-electrode strip adapted for releasable attachment to signal readout circuitry. The strip comprises an elongated support (preferably flat) adapted for releasable attachment to the readout circuitry; ...


3
Irving J Higgins, Hugh A O Hill, Elliot V Plotkin: Sensor for components of a liquid mixture. Genetics International, December 8, 1987: US04711245 (683 worldwide citation)

This invention relates to equipment and methods for detecting the presence of, measuring the amount of, and/or monitoring the level of, one or more selected components in a liquid mixture, employing an electrode sensing system.


4
Irving J Higgins, Hugh A O Hill: Enzymatic processes. National Research Development Corporation, Oblon Fisher Spivak McClelland & Maier, March 9, 1982: US04318784 (202 worldwide citation)

There are provided processes for carrying out enzymatic reactions, especially processes for the oxidative or reductive transformation of organic compounds catalyzed by enzymes, in which the enzymes require a continuing supply of reducing equivalents to regenerate reduced enzyme species in enzymatica ...


5
Timothy D Gibson, John R Woodward, Irving J Higgins, William J Aston, David A Griffiths: Colorimetric enzymic analysis. Cranfield Biotechnology, Nikaido Marmelstein Murray & Oram, June 18, 1996: US05527509 (11 worldwide citation)

A colorimetric enzymic analytical test element comprises a support and a plurality of reaction zones incorporating a dried enzyme composition, dyestuff and reagent adapted to provide a substantial dosage independent colorimetric display when the concentration of an analyte applied to the elements ex ...


6
Irving J Higgins: Biotransformations using methane-utilizing bacteria. Imperial Chemical, Cushman Darby & Cushman, April 6, 1982: US04323649 (8 worldwide citation)

A process for the partial degradation of complex cyclicorganic compounds such as 1-phenylheptane and m-chlorotoluene using methane-utilizing microorganisms or enzyme extracts thereof containing the enzymes methane mono-oxygenase and/or a de-halogenase. The preferred microorganism is Methylosinus tri ...


7
Irving J Higgins: Microbiological oxidations. Imperial Chemical, Cushman Darby & Cushman, June 19, 1984: US04455373 (7 worldwide citation)

Microbiological oxidations of organic compounds including C6 to C28 alkanes, C2 to C18 alkenes and cyclic compounds such as cyclohexane and benzene carried out using as catalysts methane-utilizing bacteria adapted to utilize methanol as a carbon source. The application also covers methane-utilizing ...


8
Irving J Higgins: Microbiological oxidation process. Imperial Chemical, Cushman Darby & Cushman, September 25, 1984: US04473643 (2 worldwide citation)

A process of oxidizing a hydrocarbon which is an alkane or alkene or substituted alkane or alkene by contacting it with a culture of a bacterium as deposited under accession number NCIB 11613 or a mutant or derivative thereof which is capable of utilizing an alkane having from 6 to 28 carbon atoms a ...