1
Lev T Perelman, Vadim Backman, Michael S Feld, George Zonios, Irving Itzkan, Ramasamy Manoharan: Measuring tissue morphology. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds P C, July 18, 2000: US06091984 (172 worldwide citation)

The present invention relates to systems and methods for measuring one or more physical characteristics of material such as tissue using optical radiation. The system can use light that is scattered by a tissue layer to determine, for example, the size of nuclei in the tissue layer to aid in the cha ...


2
Irving Itzkan: Laser system for providing target specific energy deposition and damage. Medical Laser Research and Development Corporation, Weingarten Schurgin Gagnebin & Hayes, March 29, 1988: US04733660 (157 worldwide citation)

A hand piece for use with a laser includes a scanning mechanism which controls dosimetry of radiation applied to a target area which is adjustable to limit thermal diffusion from the light absorbing portion of the irradiated target site for selective target specific energy deposition. When used for ...


3
Andrew J Berger, James F Brennan III, Ramanchandra R Dasari, Michael S Feld, Irving Itzkan, Kaz Tanaka, Yang Wang: Apparatus and methods of raman spectroscopy for analysis of blood gases and analytes. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds P C, April 1, 1997: US05615673 (128 worldwide citation)

The present invention relates to systems of methods of measuring selected analytes in blood and tissue using Raman spectroscopy to aid in diagnosis. More particularly, Raman spectra are collected and analyzed to measure the concentration of dissolved gases and other analytes of interest in blood. Me ...


4
Michael S Feld, Irving Itzkan, Douglas Albagli, Joseph A Izatt, Gary B Hayes, Richard Rava: Pulsed laser system for the surgical removal of tissue. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds, May 17, 1994: US05312396 (73 worldwide citation)

Removal of body tissue with a long pulsed lasers is achieved such that sufficient energy to remove tissue is transmitted to the desired body without damaging an optical fiber transmitting the laser radiation. Pairs of pulses having the same or different wavelengths are coupled to more effectively re ...


5
Lev T Perelman, Jun Wu, Yang Wang, Ramachandra Rac Dasari, Irving Itzkan, Michael S Feld: Optical imaging using time gated scattered light. Massachusetts Institute of Technology, Bowditch & Dewey, November 20, 2001: US06321111 (65 worldwide citation)

The present invention relates to the use of time gated scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions of internal body structures for d ...


6
Vadim Backman, Ramanchandra R Dasari, Rajan Gurjar, Irving Itzkan, Lev Perelman, Michael S Feld: Polarized light scattering spectroscopy of tissue. Massachusetts Institute of Technology, Bowditch & Dewey, June 11, 2002: US06404497 (35 worldwide citation)

The present invention relates to the use of polarized light to measure properties of tissue. More particularly, polarized light can be used to detect dysplasia in tissue as the polarization of backscattered light from such tissues is preserved while the contribution of diffusely scattered light from ...


7
Vadim Backman, Ramachandra R Dasari, Rajan Gurjar, Irving Itzkan, Lev Perelman, Michael S Feld: Polarized light scattering spectroscopy of tissue. Massachusetts Institute of Technology, Bowditch & Dewey, September 23, 2003: US06624890 (34 worldwide citation)

The present invention relates to the use of polarized light to measure properties of tissue. More particularly, polarized light can be used to detect dysplasia in tissue as the polarization of back-scattered light from such tissues is preserved while the contribution of diffusely scattered light fro ...


8
Irving Itzkan, Charles T Pike: Laser wavelength stabilization. Jersey Nuclear Avco Isotopes, Weingarten Maxham & Schurgin, June 29, 1976: US03967211 (27 worldwide citation)

A system for stabilizing the frequency of a laser employing the variation in position of interference patterns which results from a variation in laser beam frequency in passing through a Fabry Perot etalon filter. The system is particularly useful for maintaining strict frequency control at a partic ...


9
Irving Itzkan, Herbert P Kent, Michael E Mack, Richard G Morton: Laser ceilometer signal processing means. Avco Everett Research Laboratory, M E Frederick, September 15, 1981: US04289397 (24 worldwide citation)

For use in a pulsed-laser lidar such as a laser ceilometer, there are shown several examples of signal processing means for separating desired pulses due to targets such as clouds from strong background signals due to suspended particles causing poor visibility. The several examples belong to a clas ...


10
Lev T Perelman, Vadim Backman, Michael S Feld, George Zonios, Irving Itzkan, Ramasamy Manoharan: Method for measuring tissue morphology. Massachusetts Institute of Technology, Weingarten Schurgin Gagnebin & Lebovici, July 26, 2005: US06922583 (22 worldwide citation)

The present invention relates to systems and methods for measuring one or more physical characteristics of material such as tissue using optical radiation. The system can use light that is scattered by a tissue layer to determine, for example, the size of nuclei in the tissue layer to aid in the cha ...