1
Ioannis V Yannas, John F Burke, Philip L Gordon, Chor Huang: Multilayer membrane useful as synthetic skin. Massachusetts Institute of Technology, Arthur A Smith Jr, Martin M Santa, David E Brook, November 29, 1977: US04060081 (279 worldwide citation)

A multilayer membrane, which is useful as synthetic skin, is disclosed herein. A first layer is formed from a material which does not provoke an immune response and which is also insoluble and nondegradable in the presence of body fluids and/or body enzymes. Preferred materials for the first layer a ...


2
Ioannis V Yannas, John F Burke: Cell-seeding procedures involving fibrous lattices. Massachusetts Institute of Technology, Arthur A Smith Jr, David E Brook, July 10, 1984: US04458678 (213 worldwide citation)

This invention relates to the introduction of viable cells into a fibrous lattice by surgical, force-utilizing, or other manipulative techniques, all of which are referred to herein as "seeding." One embodiment comprises an autografting technique which involves intact tissue. Other embodiments which ...


3
Ioannis V Yannas, Philip L Gordon, Chor Huang, Frederick H Silver, John F Burke: Crosslinked collagen-mucopolysaccharide composite materials. Massachusetts Institute of Technology, Arthur A Smith Jr, David E Brook, July 28, 1981: US04280954 (199 worldwide citation)

Composite materials are disclosed which are formed by contacting collagen with a mucopolysaccharide and subsequently covalently crosslinking the resultant polymer. These composite materials have a balance of mechanical, chemical and physiological properties which make them useful in surgical sutures ...


4
Ioannis V Yannas: Multilayer bioreplaceable blood vessel prosthesis. Massachusetts Institute of Technology, Paul J Cook, February 20, 1990: US04902289 (170 worldwide citation)

Process for forming a multilayer blood vessel prosthesis. Each layer is formed from bioreplaceable materials which include those produced by contacting collagen with an aminopolysaccharide and subsequently covalently crosslinking the resluting polymer, polymers of hydroxyacetic acid and the like. Cr ...


5
Ioannis V Yannas, John F Burke, Dennis P Orgill, Eugene M Skrabut: Method of promoting the regeneration of tissue at a wound. Massachusetts Institute of Technology, Arthur A Smith Jr, David E Brook, December 6, 1983: US04418691 (136 worldwide citation)

This invention comprises the use of centrifugal force to introduce viable cells into a fibrous lattice, as well as fibrous lattices that are seeded with cells by the use of centrifugal force. A variety of fibrous lattices may be seeded by the methods of this invention, such as a highly porous lattic ...


6
Ioannis V Yannas, John F Burke: Method of using a fibrous lattice. Massachusetts Institute of Technology, Arthur A Smith Jr, David E Brook, March 19, 1985: US04505266 (113 worldwide citation)

This invention relates to the introduction of viable cells into a fibrous lattice by surgical, force-utilizing, or other manipulative techniques, all of which are referred to herein as "seeding." One embodiment comprises an autografting technique which involves intact tissue. Other embodiments which ...


7
Ioannis V Yannas, Martin J Forbes: Procedures for preparing composite materials from collagen and glycosaminoglycan. Massachusetts Institute of Technology, Arthur A Smith Jr, David E Brook, September 21, 1982: US04350629 (91 worldwide citation)

This invention relates to crosslinked collagen and glycosaminoglycan materials, and to procedures for preparing such materials. It has been discovered that if collagen fibrils in an aqueous acidic solution are contacted with a crosslinking agent before being contacted with glycosaminoglycan, the mat ...


8
Dennis P Orgill, Charles E Butler, Mark Barlow, Scott Ritterbush, Ioannis V Yannas, Carolyn C Compton: Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft. Brigham & Womens Hospital, Massachusetts Institute of Technology, Shriners Hospitals for Crippled Children, Hamilton Brook Smith & Reynolds P C, February 10, 1998: US05716411 (85 worldwide citation)

The present invention relates to a method of skin regeneration of a wound or burn in an animal or human. This method comprises the steps of initially covering the wound with a collagen glycosaminoglycan matrix, allowing infiltration of the grafted GC matrix by mesenchymal cells and blood vessels fro ...


9
Ioannis V Yannas, James F Kirk: Method for the preparation of collagen-glycosaminoglycan composite materials. Massachusetts Institute of Technology, Arthur A Smith Jr, Thomas J Engellenner, Richard Neeley, May 15, 1984: US04448718 (80 worldwide citation)

A process for preparing a crosslinked collagen-glycosaminoglycan composite material which comprises forming an uncrosslinked composite material from collagen and a glycosaminoglycan and contacting the uncrosslinked composite with a gaseous aldehyde until a crosslinked product having an M.sub.c of fr ...


10
Dennis P Orgill, Charles E Butler, Mark Barlow, Scott Ritterbush, Ioannis V Yannas, Carolyn C Compton: Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft. Brigham & Women s Hospital, Shriners Hospital for Crippled Children, Massachusetts Institute of Technology, Integra LifeSciences Corporation, Hamilton Brook Smith & Reynolds, February 6, 1996: US05489304 (69 worldwide citation)

The present invention relates to a method of skin regeneration of a wound or burn in an animal or human. This method comprises the steps of initially covering the wound with a collagen glycosaminoglycan matrix, allowing infiltration of the grafted GC matrix by mesenchymal cells and blood vessels fro ...