1
Sun Lijun, Borella Christopher, Li Hao, Jiang Jun, Chen Shoujun, Koya Keizo, Inoue Takayo, Du Zhenjian, Foley Kevin, Wu Yaming, Zhang Mei, Ying Weiwen: Isoxazole combretastin derivatives for the treatment of disorders. Synta Pharmaceuticals, Sun Lijun, Borella Christopher, Li Hao, Jiang Jun, Chen Shoujun, Koya Keizo, Inoue Takayo, Du Zhenjian, Foley Kevin, Wu Yaming, Zhang Mei, Ying Weiwen, DAVIS Steven G, August 24, 2006: WO/2006/089177 (40 worldwide citation)

The invention relates to compounds of structural formula (I); or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative ...


2
Kostik Elena, Vaghefi Farid, Liang Guiqing, Koya Keizo, Sun Lijun, Tatsuta Noriaki, Chen Shoujun, Inoue Takayo, Xia Zhi Qiang: Bis(thio-hydrazide amide) salts for treatment of cancers. Synta Pharmaceuticals, Kostik Elena, Vaghefi Farid, Liang Guiqing, Koya Keizo, Sun Lijun, Tatsuta Noriaki, Chen Shoujun, Inoue Takayo, Xia Zhi Qiang, DAVIS Steven G, January 26, 2006: WO/2006/009940 (18 worldwide citation)

Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I) Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R1-R4 are independently -H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted ar ...


3
Tatsuta Noriaki, Koya Keizo, Inoue Takayo: Oral formulations of bis(thiohydrazide amides). Synta Pharmaceuticals, Tatsuta Noriaki, Koya Keizo, Inoue Takayo, DAVID Steven G, May 22, 2009: WO/2009/064374 (11 worldwide citation)

Disclosed herein are oral formulations of bis(thio-hydrazide amides) compounds of the following structural formula (I) : or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R7, R8, Z, and Y are defined herein.


4
KOSTIK ELENA, VAGHEFI FARID, LIANG GUIQING, KOYA KEIZO, SUN LIJUN, TATSUTA NORIAKI, CHEN SHOUJUN, INOUE TAKAYO, XIA ZHI QIANG: [fr] Sels de bis(thio-hydrazide amide) pour le traitement du cancer, [de] Bis(thiohydrazidamid)Salze zur Behandlung von Krebs, [en] Bis(thio-hydrazide amide) salts for treatment of cancers. SYNTA PHARMACEUTICALS, April 6, 2011: EP2305642-A2

[en] Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I) 2 M + or M 2+ Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R 1 -R 4 are independently -H, an aliphatic group, a substituted aliphatic group, an aryl gro ...


5
Inoue Takayo C O Seiko Instrum, Nakamura Hisao C O Seiko Instr: An electronic apparatus and a manufacturing method therefor.. Seiko Instr, March 15, 1995: EP0643407-A1

An electronic apparatus having a switching mechanism comprises a first side pattern (1a) and a second side pattern (1b), formed on a substrate (1). An external operating member (3) is disposed at the side of the electronic apparatus. A conducting member (2a) and an insulating member (2b) are provide ...


6
Fujita Kazuhiro, Inoue Takayo: Switch device for portable electronic equipment. Seiko Instr, May 7, 1997: GB2306787-A

A switch device for portable electronic equipment comprises an operating member 2 movable into and out of a case 1 for operating a slide switch 3 connected to a circuit board 4 within the case 1. The operating member 2 is provided with waterproof packing 5 and has a recess 2a which receives a switch ...


7

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Koya Keizo, Sun Lijun, Kostik Elena, Vaghefi Farid, Chen Shoujun, Tatsuta Noriaki, Liang Guiqing, Inoue Takayo, Xia Zhi Qiang: Bis(thio-hydrazide amide) salts for treatment of cancers. Synta Pharmaceuticals, chendie lan, July 4, 2007: CN200580026445

The invention discloses a binary(sulf-hydrazideamide)binary salt presented as formula (I), Y is a covalent bond or a substituted or unsubstituted linner hydrocarbon. R1-R4 is -H, aliphatic group, substituted aliphatic group, aromatic group or substituted aromatic group, or R1 and R3 combines with bo ...


9
Sun Lijun, Borella Christopher, Li Hao, Jiang Jun, Chen Shoujun, Koya Keizo, Inoue Takayo, Du Zhenjian, Foley Kevin, Wu Yaming, Zhang Mei, Ying Weiwen: Isoxazole combretastatin derivatives for the treatment of proliferative disorders. Synta Pharmaceuticals, shouning, March 12, 2008: CN200680005310

The invention relates to compounds of structural formula (I); or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative ...


10
Kostik Elena, Vaghefi Farid, Liang Guiqing, Koya Keizo, Sun Lijun, Tatsuta Noriaki, Chen Shoujun, Inoue Takayo, Xia Zhi Qiang: Bis(thio-hydrazide amide) salts for treatment of cancers. Synta Pharmaceuticals, May 9, 2007: EP1781604-A1

Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I) Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R