1
Stephen N Cozzette, Graham Davis, Jeanne A Itak, Imants R Lauks, Randall M Mier, Sylvia Piznik, Nicolaas Smit, Susan J Steiner, Paul Van Der Werf, Henry J Wieck: Wholly microfabricated biosensors and process for the manufacture and use thereof. I Stat Corporation, Pennie & Edmonds, April 6, 1993: US05200051 (651 worldwide citation)

An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers est ...


2
Imants R Lauks, Henry J Wieck, Michael P Zelin, Philip Blyskal: Disposable sensing device for real time fluid analysis. I Stat Corporation, Pennie & Edmonds, March 17, 1992: US05096669 (537 worldwide citation)

A system comprising a disposable device and hand held reader can perform a variety of electrochemical measurements on blood or other fluids. In operation, a fluid sample is drawn into the disposable device through an orifice by capillary action. The orifice is sealed off and the disposable device is ...


3
Stephen N Cozzette, Graham Davis, Jeanne Itak, Imants R Lauks, Randall M Mier, Sylvia Piznik, Nicolaas Smit, Susan Steiner, Paul Van Der Werf, Henry J Wieck: Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor. I Stat Corporation, Pennie & Edmonds, November 5, 1991: US05063081 (500 worldwide citation)

A plurality of uniform microfabricated sensing devices are produced by establishing a plurality of base sensors on a substrate wafer, forming over at least a portion of each base sensor a permselective layer, superimposing a photoformable proteinaceous photoresist layer over a substantial portion of ...


4
Stephen N Cozzette, Graham Davis, Imants R Lauks, Randall M Mier deceased, Sylvia Piznik, Nicolaas Smit, Paul Van Der Werf, Henry J Wieck, Susan Steiner, Jeanne Itak: Process for the manufacture of wholly microfabricated biosensors. i STAT Corporation, Pennie & Edmonds, November 17, 1998: US05837454 (356 worldwide citation)

An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers est ...


5
Stephen N Cozzette, Graham Davis, Imants R Lauks, Randall M Mier, Sylvia Piznik, Nicolaas Smit, Paul Van Der Werf, Henry J Wieck: Process for the manufacture of wholly microfabricated biosensors. i Stat Corporation, Pennie & Edmonds, September 10, 1996: US05554339 (303 worldwide citation)

An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers est ...


6
Graham Davis, Chao Lin, Imants R Lauks, Raymond J Pierce: Microfabricated aperture-based sensor. i Stat Corporation, Gilberto M Pepper Hamilton Villacorta, February 29, 2000: US06030827 (288 worldwide citation)

A chemical sensor includes an enzyme layer, a diffusion layer and an analyte barrier layer positioned over the diffusion layer. Apertures are formed by microfabrication in the analyte barrier layer to allow controlled analyte flux to the diffusion layer.


7
Graham Davis, Imants R Lauks, Raymond J Pierce, Cindra A Widrig: Method of measuring gas concentrations and microfabricated sensing device for practicing same. I Stat Corporation, Lowe Price LeBlanc & Becker, May 7, 1996: US05514253 (259 worldwide citation)

A microfabricated sensing device is disclosed, including methods for using the same for the measurement of the concentration of a gas in a sample. Unique sensor configurations are described which substantially eliminate electrode cross-contamination during operation of the microfabricated sensing de ...


8
Stephen N Cozzette, Graham Davis, Lisa A Holleritter, Imants R Lauks, Sylvia Piznik, Nicolaas J Smit, Jody A Tirinato, Henry J Wieck, Michael P Zelin: Method for analytically utilizing microfabricated sensors during wet-up. I Stat Corporation, Pennie & Edmonds, May 12, 1992: US05112455 (220 worldwide citation)

A method of determining the concentration of a preselected analyte species present in a sample fluid is disclosed, which method comprises: (a) providing an external computational means, a reference electrode and at least one substantially dry-stored sensor capable of exhibiting a response to changes ...


9
Graham Davis, Imants R Lauks, Michael P Zelin: Apparatus for assaying viscosity changes in fluid samples and method of conducting same. i Stat Corporation, Lowe Price LeBlanc & Becker, May 13, 1997: US05628961 (190 worldwide citation)

The present invention relates to an apparatus for conducting a variety of assays that are responsive to a change in the viscosity of a sample fluid and relates to methods of conducting such assays. In particular, the present invention is related to the use of a cartridge for conducting one or more c ...


10
Randall M Mier, Sylvia Piznik, Imants R Lauks, Graham Davis: Method of forming a permselective layer. May 18, 1993: US05212050 (158 worldwide citation)

A method of forming a permselective layer on preselected areas of a substantially planar sensing device is disclosed. The claimed method includes establishing and confining a liquid film, derived from a silane compound mixed in a suitable solvent, within a predetermined area of the sensing device. T ...