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Takase Yasutaka, Watanabe Nobuhisa, Matsui Makoto, Ikuta Hironori, Kimura Teiji, Saeki Takao, Adachi Hideyuki, Tokumura Tadakazu, Mochida Hisatoshi, Akita Yasunori, Souda Shigeru: Nitrogenous heterocyclic compound.. Eisai, July 27, 1994: EP0607439-A1 (120 worldwide citation)

A nitrogenous heterocyclic compound represented by general formula (I) or a pharmacologically acceptable salt thereof, efficacious in treating various ischemic cardiac diseases, wherein ring A represents a benzene, pyridine or cyclohexane ring; ring B represents a pyridine, pyrimidine or imidazole r ...


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Yoshikawa Seiji, Emori Eita, Matsuura Fumiyoshi, Clark Richard, Ikuta Hironori, Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto, Aoki Mika: Xanthine derivatives as dpp-iv inhibitors. Eisai, August 27, 2003: EP1338595-A2 (68 worldwide citation)

The present invention provides novel compounds exhibiting an excellent DPPIV inhibition effect. The compounds are represented by the formula: wherein, m is 0 or 1; n is 0; R, R, R, R, R, R, R, R, R, R, R, and R each represent a hydrogen atom; X represents an alkynyl group, an aryl group, and such, w ...


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Yoshikawa Seiji, Emori Eita, Matsuura Fumiyoshi, Richard Clark, Ikuta Hironori, Kira Kazunobu, Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto: Novel fused imidazole derivative. Eisai, March 16, 2005: EP1514552-A1 (57 worldwide citation)

The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substi ...


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Kimura Teiji, Watanabe Nobuhisa, Takase Yasutaka, Hayashi Kenji, Matsui Makoto, Ikuta Hironori, Yamagishi Youji, Akasaka Kozo, Tanaka Hiroshi, Ohtsuka Issei, Saeki Takao, Kogushi Motoji, Fujimori Tohru, Saito Isao: Benzene, pyridine and pyrimidine derivative.. Eisai, April 1, 1992: EP0477778-A2 (24 worldwide citation)

A benzene, pyridine or pyrimidine derivative having the below shown formula is novle and useful as an anti-arteriosclerotic agent. wherein R stands for a lower alkyl group, an amino group which may be substituted, or the like; R stands for a group represented by the formula: (wherein R stands for an ...


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Ikuta Hironori, Yamagishi Youji, Akasaka Kozo, Yamatsu Isao, Kobayashi Seiichi, Shirota Hiroshi, Katayama Kouichi: 2-pyrrolidone derivatives, process for preparing them, pharmaceutical composition and use.. Eisai, December 17, 1986: EP0204964-A1 (14 worldwide citation)

Disclosed is a novel 2-pyrrolidone derivative, including 3-(3,5-di-tert-butyl-4-hydroxy-benzylidene)-2-pyrrolidone and an N-substituted one. The substituent includes alkyl, alkoxy, alkynyl, phenyl-alkylene, hydroxy-alkylene and amino-alkylene. It is effective as an anti-inflammatory, analgesic and a ...


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Ozaki Fumihiro, Ishibashi Keiji Parkhill Tsuku, Ikuta Hironori, Ishihara Hiroki, Souda Shigeru: Anthranilic acid derivative. Eisai, December 13, 1995: EP0686625-A1 (12 worldwide citation)

An anthranilic acid derivative having a cGMP-PDE inhibitory activity and represented by general formula (I), or a pharmacologically acceptable salt thereof wherein R, R, R and R represent each independently hydrogen, halogen, hydroxy, optionally halogenated lower alkyl, optionally halogenated lower ...


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Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto, Yoshikawa Seiji, Okada Toshimi, Ikuta Hironori, Koyanagi Mika: Pharmaceutical use of n-carbamoylazole derivatives. Eisai, November 20, 2002: EP1258480-A1 (8 worldwide citation)

The present invention relates to use of 1-carbamoylazole derivatives as medicaments and pharmaceutical compositions containing 1-carbamoylazole derivatives as the active ingredient, based on their DPPIV inhibiting effects. The present invention provides a dipeptidyl peptidase IV inhibiting agent com ...


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Tagami Katsuya, Yoshida Ichiro, Kobayashi Naoki, Fukuda Yoshio, Eguchi Yoshihito, Nakagawa Makoto, Hiyoshi Hironobu, Ikuta Hironori, Kaino Makoto, Hayashi Kenji, Ohtsuka Issei, Abe Shinya, Souda Shigeru: Phosphorus-substituted isoprenoid derivative.. Eisai, August 10, 1994: EP0609440-A1 (7 worldwide citation)

A phosphorus-substituted isoprenoid derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, useful for preventing and treating diseases for which a squalene synthetase inhibition is efficacious. In formula (I), R and R represent each hydrogen, lower alkyl, cyclo ...


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Okada Toshimi, Kurusu Nobuyuki, Tanaka Keigo, Yoshikawa Seiji, Shinmyo Daisuke, Watanabe Nobuhisa, Ikuta Hironori, Hiyoshi Hironobu, Saeki Takao, Yanagimachi Mamoru, Ito Masashi: N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient. Eisai, January 2, 2004: EP1375496-A1 (6 worldwide citation)

The present invention provides an excellent squalene synthase inhibitor. Specifically, it provides a compound (I) represented by the following formula, a salt thereof or a hydrate of them. Wherein R represents an optionally substituted vinyl group or an aromatic ring which may be substituted; n is a ...