1
Nomura Masahiro, Takahashi Yukie, Tanase Takahiro, Miyachi Hiroyuki, Tsunoda Masaki, Ide Tomohiro, Murakami Koji: Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha(ppar). Kyorin Seiyaku, March 6, 2002: EP1184366-A1 (16 worldwide citation)

The invention provides novel substituted phenylpropanoic acid derivatives that activate by binding to receptor as ligands of human peroxisome preliferant-activated receptor alpha (PPAR alpha ), and exhibit potent decreasing action on lipids in blood (cholesterol and triglyceride). It relates to subs ...


2
Fukuda Yasumichi, Asahina Yoshikazu, Katayama Satoru, Shibue Taku, Murakami Koji, Ide Tomohiro: (Ja) ビシクロアミド誘導体, (En) Bicyclic amide derivatives. Kyorin Pharmaceutical, Fukuda Yasumichi, Asahina Yoshikazu, Katayama Satoru, Shibue Taku, Murakami Koji, Ide Tomohiro, KISHIDA Masayuki, August 25, 2005: WO/2005/077900 (8 worldwide citation)

(EN) Novel bicyclic amide derivatives having excellent DPP-IV inhibiting activity or pharmacologically acceptable salts thereof. Namely, novel bicyclic amide derivatives represented by the general formula (1) or pharmacologically acceptable salts thereof (for example, (2S,4S)-1-[[(4-carbamoylbicyclo ...


3
Fukuda Yasumichi, Asahina Yoshikazu, Yokota Kazuya, Murakami Koji, Ide Tomohiro: (Ja) ビシクロ誘導体, (En) Bicyclo derivative. Kyorin Pharmaceutical, Fukuda Yasumichi, Asahina Yoshikazu, Yokota Kazuya, Murakami Koji, Ide Tomohiro, KISHIDA Masayuki, September 9, 2005: WO/2005/082847 (4 worldwide citation)

(EN) Disclosed is a novel bicyclo derivative having excellent DPP-IV inhibitory activity which is represented by the general formula (1) below or a pharmacologically acceptable salt thereof. (Specific examples thereof include (2S,4S)-1-[[N-(4-methylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrol ...


4
Fukuda Yasumichi, Asahina Yoshikazu, Nakamura Ayako, Fujita Kenji, Ide Tomohiro, Kobayashi Fumiyoshi, Kobayashi Shinji, Komatsu Kanji, Yamamoto Masanori: (Ja) グルコキナーゼ活性化物質, (En) Glucokinase-activating substance. Kyorin Pharmaceutical, Teijin Pharma, Fukuda Yasumichi, Asahina Yoshikazu, Nakamura Ayako, Fujita Kenji, Ide Tomohiro, Kobayashi Fumiyoshi, Kobayashi Shinji, Komatsu Kanji, Yamamoto Masanori, MIZUNO Katsufumi, July 3, 2008: WO/2008/078674 (4 worldwide citation)

(EN) Disclosed is a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof, wherein a carbon atom having an asterisk has an R-configuration; R1 and R2 independently represent a hydrogen atom, a halogen atom, an amino group, a hydroxy group, a hydroxyamino group, a nitr ...


5
Nomura Masahiro, Takahashi Yukie, Tanase Takahiro, Miyaji Hiroyuki, Tsunoda Masaki, Ide Tomohiro, Murakami Koji: Substituted phenylpropionic acid derivative as alfa- agonist to human peroxysome proliferator-activated receptor(ppar). Kyorin Pharmaceut, February 27, 2001: JP2001-055367 (3 worldwide citation)

PROBLEM TO BE SOLVED: To provide a new compound that has excellent human peroxysome proliferator-activated receptor α-bond avidity and the transcription activation activity, thus shows hypolipemic action and is useful as an effective and high- safety therapeutic agent for hyperlipemia. SOLUTION: Thi ...


6
Fukuda Yasumichi, Asahina Yoshikazu, Katayama Satoru, Shibue Taku, Murakami Koji, Ide Tomohiro: Bicyclic amide derivatives. Kyorin Seiyaku, November 2, 2006: EP1717225-A1 (3 worldwide citation)

Novel bicycloamide derivatives (general formula (1)) and pharmaceutically acceptable salts thereof effectively inhibit DPP-IV. The bicycloamide derivatives are represented by the general formula (1): Pharmaceutically acceptable salts thereof are also included (Example: (2S,4S)-1-[[(4-carbamoylbicycl ...


7
Nomura Masahiro, Takahashi Yukie, Tanase Takahiro, Miyachi Hiroyuki, Tsunoda Masaki, Ide Tomohiro, Murakami Koji: Derives dacide phenylpropionique substitues comme agonistes du recepteur humain active de la proliferation des peroxysomes (ppar) .alpha., Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor (ppar) .alpha.. Kyorin Pharmaceutical, Kyorin Pharmaceutical, BORDEN LADNER GERVAIS, December 4, 2000: CA2376094 (2 worldwide citation)

The invention provides novel substituted phenylpropanoic acid derivatives that activate by binding to receptor as ligands of human peroxisome preliferant-activated receptor a (PPAR.alpha.), and exhibit potent decreasing action on lipids in blood (cholesterol and triglyceride). It relates to substitu ...


8
Tsunoda Masaki, Ide Tomohiro, Murakami Koji, Anraku Tsuyoshi: (Ja) 脂質代謝異常、肥満および糖尿病の新規な予防または治療剤およびそのための使用, (En) Novel preventive or remedy for lipid metabolism disorder, obesity and diabetes and use therefor. Kyorin Pharmaceutical, Tsunoda Masaki, Ide Tomohiro, Murakami Koji, Anraku Tsuyoshi, KISHIDA Masayuki, August 31, 2006: WO/2006/090756 (2 worldwide citation)

(EN) [PROBLEMS] To provide a preventive or remedy having improved efficacy against lipid metabolism disorder, obesity and diabetes and a method of using the same. [MEANS FOR SOLVING PROBLEMS] Focusing on the multidrug therapy, a medicine is designed by using a novel phenylpropionic acid derivative s ...


9
FUKUDA YASUMICHI, ASAHINA YOSHIKAZU, TAKADOI MASANORI, OHATA KOHEI, IDE TOMOHIRO, KOBAYASHI FUMIYOSHI, KOBAYASHI SHINJI, KOMATSU KANJI, YAMAMOTO MASANORI: [fr] ACTIVATEUR DE GLUCOKINASE, [de] GLUCOKINASE-AKTIVATOR, [en] GLUCOKINASE ACTIVATOR. KYORIN SEIYAKU, TEIJIN PHARMA, November 11, 2009: EP2116533-A1 (1 worldwide citation)

[en] A compound, or a pharmaceutically acceptable salt thereof, represented by the formula (1), (wherein, the carbon atom marked with an * is in the R-configuration, R 1 represents a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, a hydroxyamino group, a nitro group, a cyano group, ...


10
Ide Tomohiro, Sasaki Hisatoshi, Hamaoka Kenko: Display shelf. Kanebo, Japan Marketing Service, C I Kasei, May 23, 2000: JP2000-139642 (1 worldwide citation)

PROBLEM TO BE SOLVED: To provide a display shelf in which length in a width direction can be easily set as desired, a high bearing load can be achieved to enable the display shelf to be solely usable, a high size precision can be achieved, and hanging display using hooks is possible. SOLUTION: A dis ...