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Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Birong Zhang, Christine Chabot, Steven Do: Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array BioPharma, Covenentech, Viksnins Harris & Padys PLLP, November 22, 2011: US08063050 (25 worldwide citation)

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatmen ...


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Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Jun Li, Christine Chabot: Pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array BioPharma, Genertech, Viksnins Harris & Padys PLLP, August 23, 2011: US08003651 (22 worldwide citation)

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for ...


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Albert J Robichaud, John M Fevig, Ian S Mitchell, Taekyu Lee, Wenting Chen, Joseph Cacciola: Substituted pyridoindoles as serotonin agonists and antagonists. Bristol Myers Squibb Company, Sammy G Duncan Jr, February 1, 2005: US06849619 (14 worldwide citation)

The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6, R7, R8, R9, X, b, k, and n, and the dashed lines are described herein. The invention is also concerned with pharmaceutical formula ...


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Albert J Robichaud, Taekyu Lee, Wei Deng, Ian S Mitchell, Wenting Chen, Christopher D McClung, Emilie J Calvello, David M Zawrotny: Substituted heterocycle fused gamma-carbolines. Bristol Myers Squibb Company, Sammy G Duncan Jr, July 25, 2006: US07081455 (11 worldwide citation)

The present invention is directed to methods of treating addictive behavior and sleep disorders by administering compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, R7, R8, R9, X, b, k, m, and n, and the dashed lines are descri ...


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Albert J Robichaud, Taekyu Lee, Wei Deng, Ian S Mitchell, Michael G Yang, Simon Haydar, Wenting Chen, Christopher D McClung, Emilie J Calvello, David M Zawrotny: Substituted heterocycle fused γ-carbolines. Bristol Myers Squibb Pharma Company, Sammy G Duncan Jr, February 27, 2007: US07183282 (9 worldwide citation)

The present invention is directed to compounds useful for treating addictive behavior and sleep disorders represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, R7, R8, R9, X, b, k, m, and n, and the dashed lines are described herein. The c ...


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Albert J Robichaud, Taekyu Lee, Wei Deng, Ian S Mitchell, Michael G Yang, Simon Haydar, Wenting Chen, Christopher D McClung, Emilie J Calvello, David M Zawrotny: Substituted heterocycle fused gamma-carbolines. Bristol Myers Squibb Pharma Co, Sammy G Duncan Jr, July 4, 2006: US07071186 (8 worldwide citation)

The present invention is directed to methods of treating addictive behavior and sleep disorders by administering compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, R7, R8, R9, X, b, k, m, and n, and the dashed lines are descri ...