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Makings Lewis R, Hurley Dennis J, Garcia Guzman, Blanco Miguel, Bergeron Daniele M, Nakatani Akiko: Modulators of muscarinic receptors. Vertex Pharmaceuticals Incorporated, Makings Lewis R, Hurley Dennis J, Garcia Guzman, Blanco Miguel, Bergeron Daniele M, Nakatani Akiko, O BRIEN Jonathan P, December 15, 2005: WO/2005/117883 (21 worldwide citation)

The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.


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Wilson Dean M, Termin Andreas P, Gonzalez Jesus E Iii, Fanning Lev T D, Neubert Timothy D, Krenitsky Paul, Joshi Pramod, Hurley Dennis J, Sheth Urvi, Boger Joshua S: Quinazolines useful as modulators of ion channels. Vertex Pharmaceuticals Incorporated, Wilson Dean M, Termin Andreas P, Gonzalez Jesus E Iii, Fanning Lev T D, Neubert Timothy D, Krenitsky Paul, Joshi Pramod, Hurley Dennis J, Sheth Urvi, Boger Joshua S, GOVINDASWAMY Nandakumar, March 16, 2006: WO/2006/028904 (7 worldwide citation)

The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.


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Makings Lewis R, Hurley Dennis J, Raffai Gabriel: Modulators of muscarinic receptors. Vertex Pharmaceuticals Incorporated, Makings Lewis R, Hurley Dennis J, Raffai Gabriel, O BRIEN Jonathan P, February 21, 2008: WO/2008/021375 (2 worldwide citation)

The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.


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Hurley Dennis J, Bergeron Daniele M, Drutu Ioana, Garcia Guzman, Blanco Miguel, Makings Lewis R, Nakatani Akiko, Raffai Gabriel, Silina Alina: Modulators of muscarinic receptors. Vertex Pharmaceuticals Incorporated, Hurley Dennis J, Bergeron Daniele M, Drutu Ioana, Garcia Guzman, Blanco Miguel, Makings Lewis R, Nakatani Akiko, Raffai Gabriel, Silina Alina, O BRIEN Jonathan P, June 1, 2006: WO/2006/058294 (2 worldwide citation)

The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.


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MAKINGS LEWIS R, GARCIA GUZMAN BLANCO MIGUEL, HURLEY DENNIS J, DRUTU IOANA, RAFFAI GABRIEL, BERGERON DANIELE M, NAKATANI AKIKO, TERMIN ANDREAS P, SILINA ALINA: Modulators of muscarinic receptors, Modulatoren von muskarinischen Rezeptoren, Modulateurs des récepteurs muscariniques. VERTEX PHARMA, September 14, 2011: EP2364705-A2

The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith or treating muscarinic receptor mediated diseases.


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MAKINGS LEWIS R, GARCIA GUZMAN BLANCO MIGUEL, HURLEY DENNIS J, DRUTU IOANA, RAFFAI GABRIEL, BERGERON DANIELE M, NAKATANI AKIKO, TERMIN ANDREAS P, SILINA ALINA: Modulators of muscarinic receptors, Modulatoren von muskarinischen Rezeptoren, Modulateurs des recepteurs muscariniques. VERTEX PHARMA, October 12, 2011: EP2374455-A2

The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith or treating muscarinic receptor mediated diseases.


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