1
Teeling Jessica, Ruuls Sigrid, Glennie Martin, Van de, Winkel Jan G J, Parren Paul, Petersen Jorgen, Baadsgaard Ole D M Sc, Huang Haichun: Human monoclonal antibodies against cd20. Genmab, Teeling Jessica, Ruuls Sigrid, Glennie Martin, Van de, Winkel Jan G J, Parren Paul, Petersen Jorgen, Baadsgaard Ole D M Sc, Huang Haichun, DECONTI Giulio A, April 29, 2004: WO/2004/035607 (49 worldwide citation)

Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotype ...


2
Wild Kenneth D Jr, Treanor James J S, Huang Haichun, Inoue Heather, Zhang Tie J, Martin Frank: Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors. Amgen, Wild Kenneth D Jr, Treanor James J S, Huang Haichun, Inoue Heather, Zhang Tie J, Martin Frank, DERRY Jason J, March 3, 2005: WO/2005/019266 (40 worldwide citation)

This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related ...


3
Varnum Brian, Vezina Chris, Witte Alison, Qian Xueming, Martin Frank, Huang Haichun, Elliott Gary: Therapeutic human anti-il-1r1 monoclonal antibody. Amgen, Varnum Brian, Vezina Chris, Witte Alison, Qian Xueming, Martin Frank, Huang Haichun, Elliott Gary, DERRY Jason J, March 18, 2004: WO/2004/022718 (38 worldwide citation)

Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 ...


4
Korman Alan J, Selby Mark J, Wang Changyu, Srinivasan Mohan, Passmore David B, Huang Haichun, Chen Haibin: Human monoclonal antibodies to programmed death ligand 1 (pd-l1). Medarex, Korman Alan J, Selby Mark J, Wang Changyu, Srinivasan Mohan, Passmore David B, Huang Haichun, Chen Haibin, FEHLNER Paul L, January 11, 2007: WO/2007/005874 (30 worldwide citation)

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to PD-Ll with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of ...


5
Terrett Jonathan Alexander, Lu Li Sheng, King David John, Cardarelli Josephine M, Pan Chin, Huang Haichun, Coccia Marco A: Human monoclonal antibodies to cd70. Medarex, Terrett Jonathan Alexander, Lu Li Sheng, King David John, Cardarelli Josephine M, Pan Chin, Huang Haichun, Coccia Marco A, FEHLNER Paul F, April 5, 2007: WO/2007/038637 (24 worldwide citation)

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of t ...


6
Boyd Sharon Elaine, Chen Liang, Gangwar Sanjeev, Guerlavais Vincent, Horgan Kilian, Sufi Bilal, Huang Haichun, King David John, Pan Chin, Cardarelli Josephine M: Antibody-drug conjugates and methods of use. Medarex, Boyd Sharon Elaine, Chen Liang, Gangwar Sanjeev, Guerlavais Vincent, Horgan Kilian, Sufi Bilal, Huang Haichun, King David John, Pan Chin, Cardarelli Josephine M, BLACK Bruce E, April 5, 2007: WO/2007/038658 (21 worldwide citation)

The present disclosure provides antibody-drug conjugates that are potent cytotoxins, wherein the drug is linked to the antibody through a linker. The disclosure is also directed to compositions containing the antibody-drug conjugates, and to methods of treatment using them.


7
Deshpande Shrikant, Huang Haichun, Srinivasan Mohan, Cardarelli Josephine M, Wang Changyu, Passmore David, Rangan Vangipuram S, Lane Thomas E, Keirstead Hans S, Liu Michael T: Ip-10 antibodies and their uses. Medarex, Deshpande Shrikant, Huang Haichun, Srinivasan Mohan, Cardarelli Josephine M, Wang Changyu, Passmore David, Rangan Vangipuram S, Lane Thomas E, Keirstead Hans S, Liu Michael T, DECONTI Giulio A, June 30, 2005: WO/2005/058815 (17 worldwide citation)

The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP- 10 with high affinity, inhibit the binding of IP- 10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibo ...


8
Huang Haichun, Holmes Steven, Mason Sean: Human monoclonal antibodies to heparanase. Medarex, Celltech R & D, Huang Haichun, Holmes Steven, Mason Sean, DECONTI Giulio A, May 27, 2004: WO/2004/043989 (17 worldwide citation)

Isolated human monoclonal antibodies which bind to and inhibit human heparanase, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple is ...


9

10
Rao Naik Chetana, King David John, Liu Jie, Huang Haichun, Passmore David B, Bell Alasdair Fraser, Cardarelli Josephine M, Pan Chin, Thi Do To Uyen, Chen Sharline: Cd19 antibodies and their uses. Medarex, Rao Naik Chetana, King David John, Liu Jie, Huang Haichun, Passmore David B, Bell Alasdair Fraser, Cardarelli Josephine M, Pan Chin, Thi Do To Uyen, Chen Sharline, BAKER BOTTS, January 4, 2007: WO/2007/002223 (11 worldwide citation)

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD 19 with high affinity. Nucleic acid molecules encoding such CD 19 antibodies, expression vectors, host cells and methods for expressing the CD 19 antibodies are also ...