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Bender Steven Lee, Casperson Gerald Fries, Hu Lowe Dana Dan, Jiang Xin, Li Gang, North Michael Aidan, Wang Jianying, Wickman Grant, Brams Peter, Huang Haichun, Devaux Brigitte, Chen Haibin, Tanamachi Dawn M, Toy Kristopher, Yang Lan, Sproul Tim W, Yamanaka Mark: Alpha 5 - beta 1 antibodies and their uses. Medarex, Pfizer, Bender Steven Lee, Casperson Gerald Fries, Hu Lowe Dana Dan, Jiang Xin, Li Gang, North Michael Aidan, Wang Jianying, Wickman Grant, Brams Peter, Huang Haichun, Devaux Brigitte, Chen Haibin, Tanamachi Dawn M, Toy Kristopher, Yang Lan, Sproul Tim W, Yamanaka Mark, BRADY James W, August 13, 2009: WO/2009/100110 (5 worldwide citation)

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells ...


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NORTH MICHAEL AIDAN, WANG JIANYING, WICKMAN GRANT RAYMOND, ZHANG JINGCHUAN, AMUNDSON KARIN KRISTINA, BEDIAN VAHE, BELOUSKI SHELLEY SIMS, HU LOWE DANA DAN, JIANG XIN, KARLICEK SHANNON MARIE, KELLERMANN SIRID AIMEE, THOMSON JAMES ARTHUR: Human monoclonal antibodies to activin receptor-like kinase-1 (ALK-1), Humane monoklonale Antikörper gegen activinrezeptorähnliche Kinase-1 (ALK-1), Anticorps monoclonaux humains dirigés contre la kinase-1 du type du récepteur dactivine (ALK-1). AMGEN FREMONT, Pfizer, May 2, 2012: EP2447283-A2

The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular doman (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to h ...


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BENDER STEVEN LEE, CASPERSON GERALD FRIES, HU LOWE DANA DAN, JIANG XIN, LI GANG, NORTH MICHAEL AIDAN, WANG JIANYING, WICKMAN GRANT, BRAMS PETER, HUANG HAICHUN, DEVAUX BRIGITTE, CHEN HAIBIN, TANAMACHI DAWN, TOY KRISTOPHER, YANG LAN, SPROUL TIM W, YAMANAKA MARK: [fr] Anticorps Alpha 5 - beta 1 et leurs utilisations, [de] Alpha-5-Beta-1-Antikörper und ihre Verwendungen, [en] Alpha 5 - beta 1 antibodies and their uses. SQUIBB BRISTOL MYERS CO, Pfizer, September 25, 2013: EP2641612-A1

[en] The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin +-51 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host c ...


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BENDER STEVEN LEE, CASPERSON GERALD FRIES, HU LOWE DANA DAN, JIANG XIN, LI GANG, NORTH MICHAEL AIDAN, WANG JIANYING, WICKMAN GRANT, BRAMS PETER, HUANG HAICHUN, DEVAUX BRIGITTE, CHEN HAIBIN, TANAMACHI DAWN, TOY KRISTOPHER, YANG LAN, SPROUL TIM W, YAMANAKA MARK: [fr] Anticorps Alpha 5 - bêta 1 et leurs utilisations, [de] Alpha-5-beta-1-Antikörper und deren Verwendungen, [en] Alpha 5 - beta 1 antibodies and their uses. SQUIBB BRISTOL MYERS CO, Pfizer, October 16, 2013: EP2650017-A2

[en] The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin +-51 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host c ...


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North Michael Aidan, Amundson Karin Kristina, Bedian Vahe, Belouski Shelley Sims, Hu Lowe Dana Dan, Jiang Xin, Karlicek Shannon Marie, Kellermann Sirid Aimee, Thomson James Arthur, Wang Jianying, Wickman Grant Raymond, Zhang Jingchuan: Human monoclonal antibodies to activin receptor-like kinase-1. Amgen Fremont, Luo Juhua, August 26, 2009: CN200680041490

The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular doman (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to h ...


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North Michael Aidan, Amundson Karin Kristina, Bedian Vahe, Belouski Shelley Sims, Hu Lowe Dana Dan, Jiang Xin, Karlicek Shannon Marie, Kellermann Sirid Aimee, Thomson James Arthur, Wang Jianying, Wickman Grant Raymond, Zhang Jingchuan: Human monoclonal antibodies to activin receptor-like kinase-1. Amgen Fremont, Pfizer, June 25, 2008: EP1933871-A2

The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular doman (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to h ...