1
Howard M Chandler: Barrier-controlled assay device. SmithKline Diagnostics, William H May, Gary T Hampson, March 4, 1997: US05607863 (92 worldwide citation)

An assay device for detection and/or determination of an analyte in a test sample uses a barrier containing an aperture to control the application of reagents to the device for greater reproducibility of results. In its simplest form, the device comprises: (1) a chromatographic medium having a first ...


2
Howard M Chandler, Roger N Piasio, Karen Prouty: Immunochromatographic assay device. SmithKline Diagnostics, William H May, P R Merchant & Gould Harder, March 2, 1999: US05877028 (63 worldwide citation)

A chromatographic assay device for use with immunoassays allows rapid and convenient assays of analytes of biological interest, and permits extractions to be carried out in situ, avoiding the use of separate extraction vessels. The device has a wide dynamic range and avoids interference from particu ...


3
Howard M Chandler: Assay device. Beckman Coulter, William H May, Margaret A Merchant & Gould Kivinski, January 25, 2000: US06017767 (61 worldwide citation)

A chromatographic assay device for use with immunoassays allows rapid and convenient assays of analytes of biological interest, and permits extractions to be carried out in situ, avoiding the use of separate extraction vessels. The device has a wide dynamic range and avoids interference from particu ...


4
Howard M Chandler: Interrupted-flow assay device. SmithKline Diagnostics, Merchant Gould Smith Edell Welter & Schmidt, November 21, 1995: US05468648 (47 worldwide citation)

The present invention provides chromatographic assay devices that can perform multiple assays simultaneously in the same test strip, as well as methods for their use. One of the assays can be an immunological assay to detect an antigen, such as human chorionic gonadotropin, while another assay can b ...


5
Howard M Chandler: Competitive immunoassay device. SmithKline Diagnostics, William H May, Arnold Merchant & Gould Grant, July 15, 1997: US05648274 (46 worldwide citation)

A chromatographic assay device for detection and/or determination of an analyte in a competitive immunoassay gives a semiquantitative or quantitative indication of analyte concentration in a single assay device while also giving a positive indication that flow has occurred properly through the devic ...


6
Daniel Fitzgerald, Howard M Chandler, Larry LaPointe: Opposable-element chromatographic assay device for detection of analytes in whole blood samples. Beckman Coulter, William H May, D David Hill, Hogan & Hartson, March 4, 2003: US06528321 (46 worldwide citation)

A chromatographic assay device according to the present invention provides a unidirectional immunoassay for an analyte in a whole blood sample with improved sensitivity and freedom from interference. Such a device comprises: (1) a first opposable component including: (a) a sample application zone co ...


7
Howard M Chandler: Device for performing quantitative chemical and immunochemical assays. Allelix, Ridout & Maybee, April 29, 1986: US04585623 (44 worldwide citation)

The invention provides a device for performing chemical or immunochemical assays quickly and on site. The device comprises a plastic molded body which may be miniaturized. The device is provided with a plurality of tubes for containing assay reagents, a small bore tube in which the assay is carried ...


8
Howard M Chandler: Device for performing qualitative enzyme immunoassays. Allelix, Ridout & Maybee, May 12, 1987: US04665034 (39 worldwide citation)

The invention relates to a device and method for performing qualitative enzyme immunoassays. The device comprises at least one tube having antibody, antigen or hapten attached to an internal surface thereof. A first syringe is connectable to a first end of the tube or tubes and supplies a flow of te ...


9
Howard M Chandler: Opposable-element assay device employing conductive barrier. Smithkline Diagnostics, William H May, P R Merchant & Gould Harder, February 9, 1999: US05869345 (37 worldwide citation)

A chromatographic assay device for use with immunoassays allows rapid and convenient assays of analytes of biological interest, and permits extractions to be carried out in situ, avoiding the use of separate extraction vessels. The device has a wide dynamic range and avoids interference from particu ...


10
Howard M Chandler: Opposable-element assay devices, kits, and methods employing them. Beckman Coulter, William H May, Margaret A Merchant & Gould Kivinski, December 7, 1999: US05998220 (36 worldwide citation)

A chromatographic assay device for use with immunoassays allows rapid and convenient assays of analytes of biological interest, and permits extractions to be carried out in situ, avoiding the use of separate extraction vessels. The device has a wide dynamic range and avoids interference from particu ...