1
Do Quyen Quyen Thuy, Guo Chuangxing, Humphries Paul Stuart, Marakovits Joseph Timothy, Dong Liming, Hou Xinjun, Johnson Mary Catherine: Benzimidazole or indole amides as inhibitors of pin1. Pfizer, Do Quyen Quyen Thuy, Guo Chuangxing, Humphries Paul Stuart, Marakovits Joseph Timothy, Dong Liming, Hou Xinjun, Johnson Mary Catherine, FULLER Grover F Jr, April 20, 2006: WO/2006/040646 (7 worldwide citation)

The invention relates to compounds of the formula (1) and to pharmaceutically acceptable salts and solvates thereof, wherein the variables are defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula (1) and to pharma ...


2
Guo Chuangxing, Dagostino Eleanor Ferronyalka, Dong Liming, Hou Xinjun, Margosiak Stephen Anthony: Phosphate/sulfate ester compounds and pharmaceutical compositions for inhibiting protein interacting nima (pin1). Pfizer, Guo Chuangxing, Dagostino Eleanor Ferronyalka, Dong Liming, Hou Xinjun, Margosiak Stephen Anthony, LUMB J Trevor, October 14, 2004: WO/2004/087720 (6 worldwide citation)

Phosphate/sulfate ester compounds that modulate and/or inhibit the activity of protein interacting NIMA (PIN1), and to pharmaceutical compositions containing such compounds are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to ...


3
Guo Chuangxing, Augelli Szafran Corinne E, Barta Nancy Sue, Bender Steven Lee, Bigge Christopher Franklin, Caprathe Bradley William, Chatterjee Arindam, Deal Judith, Dong Liming, Fay Lorraine Kathleen, Hou Xinjun, Hudack Raymond Andrew Jr: Heterobicycles fkbp-ligands. Agouron Pharma, June 2, 2004: EP1423119-A1

Diazabicyclo[3.3.1]nonane derivatives that inhibit the peptidyl-prolyl isomerase enzyme activity associated with FK-506 binding proteins (FKBP) are described for treating neurological disorders. Also described are compounds useful for preparing such inhibitors.


4
Guo Chuangxing, Dagostino Eleanor Ferronyalka, Dong Liming, Hou Xinjun, Margosiak Stephen Anthony: Phosphate/sulfate ester compounds and pharmaceutical compositions for inhibiting protein interacting nima (pin1). Pfizer, December 14, 2005: EP1603926-A1

Phosphate/sulfate ester compounds that modulate and/or inhibit the activity of protein interacting NIMA (PIN1), and to pharmaceutical compositions containing such compounds are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to ...


5
Matthews David Allen, Dagostino Eleanor Ferro Nyalka, Ferre Rose Ann, Gaur Smita, Guo Chuangxing, Hou Xinjun, Margosiak Stephen, Mroczkowski Barbara, Nakayama Grace Reiko, Parge Hans Erich, Zhu Jeff Xianchao: Pin1 peptidyl-prolyl isomerase polypeptides, their crystal structures, and use thereof for drug design. Pfizer, April 13, 2005: EP1521825-A2

Polypeptides containing the PIN1 peptidyl-prolyl isomerase domain but not containing the PIN1 WW domain are described. Also described are crystal structures of these polypeptides, including the crystal structure of a PIN1 PPlaseaigand complex. The structure coordinate data derived from these crystal ...


6
Matthews David Allan, Dagostino Eleanor Ferronyalka, Ferre Rose Ann, Gaur Smita, Guo Chuangxing, Hou Xinjun, Margosiak Stephen, Mroczkowski Barbara, Nakayama Grace Reiko, Parge Hans Erich, Zhu Jeff Xianchao: Pin1 peptidyl-prolyl isomerase polypeptides, their crystal structures, and use thereof for drug design. Pfizer, Matthews David Allan, Dagostino Eleanor Ferronyalka, Ferre Rose Ann, Gaur Smita, Guo Chuangxing, Hou Xinjun, Margosiak Stephen, Mroczkowski Barbara, Nakayama Grace Reiko, Parge Hans Erich, Zhu Jeff Xianchao, LUMB J Trevor, January 15, 2004: WO/2004/005315

Polypeptides containing the PIN1 peptidyl-prolyl isomerase domain but not containing the PIN1 WW domain are described. Also described are crystal structures of these polypeptides, including the crystal structure of a PIN1 PPlaseaigand complex. The structure coordinate data derived from these crystal ...


7

8
Guo Chuangxing, Dong Liming, Hou Xinjun J, Vanderpool Darin Louis, Villafranca Jesus Ernest: Compounds, compositions, and methods for stimulating neuronal growth and elongation. Agouron Pharmaceuticals, WOODWARD David W, June 7, 2001: WO/2001/040185

The present invention relates to compounds of formula (I) wherein A, B, X, D are defined in claim 1, and pharmaceutical compositions containing them for stimulating neuroite outgrowth in nerve cells leading to nerve regeneration. These methods, compounds and compositions inhibit rotamase enzyme acti ...


9
Guo Chuangxing, Dong Liming, Hou Xinjun J, Vanderpool Darin Louis, Villafranca Jesus Ernest: Compounds, compositions, and methods for stimulating neuronal growth and elongation. Agouron Pharma, September 11, 2002: EP1237869-A1

The present invention relates to compounds of formula (I) wherein A, B, X, D are defined in claim 1, and pharmaceutical compositions containing them for stimulating neuroite outgrowth in nerve cells leading to nerve regeneration. These methods, compounds and compositions inhibit rotamase enzyme acti ...