1
Asano Osamu, Harada Hitoshi, Hoshino Yorihisa, Yoshikawa Seiji, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Nagata Kaya, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi: Purine derivatives and adenosine a2 receptor antagonists serving as preventives/remedies for diabetes. Eisai, November 22, 2000: EP1054012-A1 (63 worldwide citation)

The present invention provides a preventive or therapeutic agent of a new type for diabetes mellitus and diabetic complications on the basis of an adenosine A2 receptor antagonistic action. A purine compound represented by the formula (I), its pharmacologically acceptable salt or hydrates thereof ha ...


2
Miyazawa Shuhei, Hoshino Yorihisa, Shibata Hisashi, Hirota Kazuo, Kameyama Takaaki, Abe Shinya, Yamanaka Takashi: Aminobenzoic acid derivatives.. Eisai, March 29, 1995: EP0645391-A2 (17 worldwide citation)

To provide a compound which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio. An aminobenzoic acid derivative represented by the general formula (I) or (II) or a pharmacologically acceptable salt thereof: [wherein R represents a gro ...


3
Asano Osamu, Harada Hitoshi, Hoshino Yorihisa, Yoshikawa Seiji, Inoue Takashi, Horizoe Tatsuo, Yasuda Nobuyuki, Nagata Kaya, Nagaoka Junsaku, Murakami Manabu, Kobayashi Seiichi, Ohashi Kaya: Purine compounds and adenosine a2 receptor antagonist as preventive or therapeutic agent for diabetes mellitus. Eisai, April 9, 2003: EP1300147-A1 (12 worldwide citation)

The present invention relates to the use of A2 receptor antagonists and their pharmacologically acceptable salts or hydrates for preparing medicaments for preventing or treating diabetes mellitus or diabetic complications, and for preparing improving agents for impaired glucose tolerance, potentiati ...


4
Hibi Shigeki, Kikuchi Koichi, Hoshino Yorihisa, Soejima Motohiro, Yoshiuchi Tatsuya, Shin Kogyoku, Ono Mutsuko, Takahashi Yoshinori, Shibata Hisashi, Ino Mitsuhiro, Hirakawa Tetsuya: Pyrazolo 1,5-a pyridines and medicines containing the same. Eisai, February 18, 2004: EP1389618-A1 (12 worldwide citation)

Compounds represented by the general formula: Äwherein R represents methoxy, ethyl, methylthio, etc., R, R and R each represent hydrogen, a halogen, etc., R and R each represent -X-X-X (wherein X represents a single bond or -CO-, X represents a single bond, -NR, etc. and X and R each represent hydro ...


5
Miyazawa Shuhei, Hibi Shigeki, Yoshimura Hiroyuki, Mori Takashi, Hoshino Yorihisa, Nagai Mitsuo, Kikuchi Kouichi, Shibata Hisashi, Hirota Kazuo, Yamanaka Takashi, Yamatsu Isao, Mizuno Masanori: Aminobenzoic acid derivatives.. Eisai, August 11, 1993: EP0554794-A1 (7 worldwide citation)

An aminobenzoic acid derivative represented by the following general formulas (I), (I-2) or (I-3), or a pharmacologically acceptable salt thereof, which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio and which is efficacious as a ...


6
Hibi Shigeki, Hoshino Yorihisa, Yoshiuchi Tatsuya, Shin Kogyoku, Kikuchi Kouichi, Soejima Motohiro, Tabata Mutsuko, Takahashi Yoshinori, Shibata Hisashi, Hida Takayuki, Hirakawa Tetsuya, Ino Mitsuhiro: Fused heterotricyclic compounds, process for preparing the compounds and drugs containing the same. Eisai, September 11, 2002: EP1238979-A1 (5 worldwide citation)

The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof. Wherein A, B and D are the same a ...


7
Hibi Shigeki, Hoshino Yorihisa, Kikuchi Koichi, Shin Kogyoku, Takahashi Yoshinori, Fujisawa Masae, Shibata Hisashi, Ino Mitsuhiro: (Ja) 7−フェニルピラゾロピリジン化合物, (En) 7-phenyl pyrazolopyridine compounds. Eisai, Hibi Shigeki, Hoshino Yorihisa, Kikuchi Koichi, Shin Kogyoku, Takahashi Yoshinori, Fujisawa Masae, Shibata Hisashi, Ino Mitsuhiro, HASEGAWA Yoshiki, May 6, 2004: WO/2004/037822 (4 worldwide citation)

(EN) A compound represented by the following general formula, its salt or hydrates thereof: (I) wherein R1 represents methoxy, methyltio, ethyl, etc.; R5 and R6 independently represent each cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and two of R40, R41 and R42 are C1-6 alkoxy while the re ...


8
Hibi Shigeki, Takahashi Yoshinori, Hoshino Yorihisa, Kikuchi Koichi, Soejima Motohiro, Yoshiuchi Tatsuya, Shin Kogyoku, Ono Mutsuko, Shibata Hisashi, Ino Mitsuhiro, Hirakawa Tetsuya: Bicyclic nitrogenous fused-ring compound. Eisai, November 26, 2003: EP1364952-A1 (2 worldwide citation)

The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein R denotes a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group and t ...


9
Hibi Shigeki, Hoshino Yorihisa, Kikuchi Koichi, Shin Kogyoku, Takahashi Yoshinori, Fujisawa Masae, Shibata Hisashi, Ino Mitsuhiro: 7-phenyl pyrazolopyridine compounds. Eisai, July 20, 2005: EP1555265-A1 (2 worldwide citation)

A compound represented by the formula: Äwherein R is methoxy, methylthio, ethyl, etc.; R and R are each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and two of R, R and R are C1-6 alkoxy while the remaining one is methoxymethyl, etc.Ü, a salt thereof, or a hydrate of the foreg ...


10
Hibi Shigeki, Hoshino Yorihisa, Yoshiuchi Tatsuya, Shin Kogyoku, Kikuchi Kouichi, Soejima Motohiro, Tabata Mutsuko, Takahashi Yoshinori, Shibata Hisashi, Hida Takayuki, Hirakawa Tetsuya, Ino Mitsuhiro: Fused heterotricyclic compounds, process for preparing the compounds and drugs containing the same. Eisai, Hibi Shigeki, Hoshino Yorihisa, Yoshiuchi Tatsuya, Shin Kogyoku, Kikuchi Kouichi, Soejima Motohiro, Tabata Mutsuko, Takahashi Yoshinori, Shibata Hisashi, Hida Takayuki, Hirakawa Tetsuya, Ino Mitsuhiro, FURUYA Kaoru, June 14, 2001: WO/2001/042247 (1 worldwide citation)

Compounds represented by general formula (I) are provided, which exhibit antagonism against corticotropin-releasing factor receptor, wherein A, B and C are each independently -(CR?1¿R?2¿)¿m?- (wherein R?1¿ and R?2¿ are each C¿1-6? alkyl or the like, and m is an integer of 1 to 4), -NR?3¿- (wherein R ...