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Oinuma Hitoshi, Yamanaka Motosuke, Miyake Kazutoshi, Hoshiko Tomonori, Minami Norio, Shoji Tadao, Daiku Yoshiharu, Sawada Kohei, Nomoto Kenichi: Sulfonamidolphenyl derivates and therapeutic and preventive agents for arrythmia containing same.. Eisai, March 1, 1989: EP0304888-A1 (10 worldwide citation)

Piperidine compounds of general formula (XX) are provided which are useful as medicaments for the treatment or prophylaxis of arrhythmia. in which R is a lower alkyl and W is: wherein X is -S-, -SO- or -SO2-; R is hydrogen or -(CH2)n-Y; n is an integer of 1 to 5; Y is an aryl, pyridyl or a substitut ...


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Yamanaka Motosuke, Hoshiko Tomonori, Suda Shinji, Yoneda Naoki, Mori Nobuyuki, Shino Mitsumasa, Ishihara Hiroki, Saito Mamoru, Matsuoka Toshiyuki: Pyrrolidine compound and pharmaceutical use.. Eisai, August 8, 1990: EP0381235-A2 (8 worldwide citation)

A pyrrolidine compound having the formula and a pharmacologically acceptable salt thereof is disclosed. It is useful in the pharmaceutical field. in which X is hydrogen, a halogen, or a lower alkyl, Y is -(CH2)n-, n being zero, 1 or 2, -S(O)p-, p being zero, 1 or 2, -O-, or -NH- and R is phenyl, a s ...


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Nomoto Kenichi, Oinuma Hitoshi, Yamanaka Motosuke, Sawada Kohei, Miyake Kazutoshi, Minami Norio, Daiku Yoshiharu, Hoshiko Tomonori, Shoji Tadao: Derives de n-(phenyle substitue)-alcanesulfonamide, N-(substituted phenyl)alkanesulfonamide derivatives. Eisai, SMART & BIGGAR, December 5, 1989: CA1263658

Abstract A novel compound of the general formula isuseful to treat arrhythmia. Image (XX)in which R1 is a lower alkyl and W is: (1) Image (2) Image (3) Image X is -S-, -SO- or -SO2-, R2 is hydrogen or -(CH2)n-Yn is an integer of 1 to 5, Y is an aryl, pyridyl ora substituted pyridyl, X' is -CO- or -C ...


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Sawada Kohei, Nomoto Kenichi, Daiku Yoshiharu, Oinuma Hitoshi, Yamanaka Motosuke, Hoshiko Tomonori, Miyake Kazutoshi, Shoji Tadao, Minami Norio: Derive piperazine et composition pharmaceutique en contenant, Piperidine derivative and pharmaceutical composition containing the same. Eisai, SMART & BIGGAR, May 18, 1993: CA1317941

5702-256 Abstract of the Disclosure A new piperidine compound is pharmacologicallyeffective for treatment of the arrythmia and is definedby the formula: Imagein which R1 is a lower alkyl or a tolyl, R2 ishydrogen, hydroxyl, a lower alkoxy or a lower alkyl, R3 is hydrogen, a lower alkyl, a lower alke ...


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Hoshiko Tomonori, Sato Keizo, Suda Shinji, Oinuma Hitoshi, Yoneda Naoki, Miyake Kazutoshi, Minami Norio, Matsuoka Toshiyuki, Ishihara Hiroki, Mori Nobuyuki, Shino Mitsumasa, Soda Shigeru: Pyrrolidine derivative. Eisai, November 29, 1994: JP1994-329626

PURPOSE: To provide a new pyrrolidine derivative having high affinity to the receptor of dopamine I and useful as an agent for treating and preventing hypertension and cardiac failures. CONSTITUTION: A compound of formula I [Y is -NH-, -(CH2)n- (n is 0-2), -S(O)p- (p is 0-2); R1, R2 are H, OH, -SO2N ...