1
Horwell David Christopher, Pritchard Martyn Clive, Richardson Reginald Stewart, Roberts Edward, Aranda Julian: N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives.. Warner Lambert Co, January 2, 1991: EP0405537-A1 (58 worldwide citation)

Novel unnatural dipeptoids of alpha -substituted Trp-Phe derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further the compounds are antianxiety agents and antiulcer agents and are agents ...


2
Horwell David Christopher, Scopes David Ian Carter: Pyrimidine derivatives for the treatment of amyloid-related diseases. Senexis, Horwell David Christopher, Scopes David Ian Carter, CHAPMAN Paul W, November 8, 2007: WO/2007/125351 (51 worldwide citation)

The present invention provides (I) These compounds are useful in prevention and treatment of neurodegenerative disorders, such as Alzheimer's, Parkinson's and Huntington's as well as type II diabetes.


3
Horwell David Christopher, Rees David C: 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics.. Warner Lambert Co, June 13, 1990: EP0372466-A2 (49 worldwide citation)

The invention concerns a series of novel 2-amino-monomethoxycyclohexyl amides of the general formula having analgesic and neuroprotective activity. The compounds bind selectively to the kappa opioid receptor. Pharmaceutical compositions containing the compounds, methods of using them, and processes ...


4

5
Horwell David Christopher, Hughes John, Woodruff Geoff Neil: Central cholecystokinin antagonists for treatment of psychiatric disorders.. Warner Lambert Co, February 6, 1991: EP0411668-A2 (21 worldwide citation)

Pharmaceutical compositions and methods of using cholecystokinin-ligands (e.g. lorglumide) as antipsychotic, antianxiety drugs and agents useful in the treatment or prevention of withdrawal symptoms caused by withdrawal of chronic or long term use of diazepam, alcohol, cocaine or nicotine are descri ...


6
Horwell David Christopher, Rees David Charles, Goel Om Prakash: 2-amino-3 or 6-methoxycyclohexyl amide derivatives.. Warner Lambert Co, July 28, 1993: EP0552386-A1 (19 worldwide citation)

The invention concerns novel 2-amino-3- or 6-methoxycyclohexyl amides of the formula having analgesic and neuroprotective activity. The compounds bind selectively to the kappa opioid receptor. Pharmaceutical compositions containing the compounds, methods of using them, and processes for preparing th ...


7
Horwell David Christopher, Rees David C: (substituted)Amino)-8-(substituted)carbonyl)-methylamino-1-oxaspiro (4,5)decanes as diuretics antiinflammatory, and cerebrovascular agents.. Warner Lambert Co, October 24, 1990: EP0393696-A2 (10 worldwide citation)

Methods for using substituted phenoxy-, 1-, and 2-naphthalenyloxy-, indenyl-, indolyl-, benzo[b]-furanyl-, and benzo[b]thienylcarboxamides of 7,8-(substituted-diamino)-1-oxaspiro[4.5]decanes as cerebrovascular, diuretic, and antiinflammatory agents are disclosed. Pharmaceutical compositions employin ...


8
Scopes David Ian Carter, Horwell David Christopher: Pyridine derivatives for the treatment of amyloid-related diseases. Senexis, Scopes David Ian Carter, Horwell David Christopher, CHAPMAN Paul William, April 9, 2009: WO/2009/044160 (9 worldwide citation)

a compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof: wherein X and Y are independently NR5 or O; W and Z are independently a bond or (CH2)mCH(R7)(CH2)n; m = 0-1, n = 0-2; R is hydrogen or halogen; R1 and R2 are independently selected from hydrogen, halogen, CF3, CN, OR ...


9

10
Ratcliffe Giles Stuart, Morrell Andrew Ian, Hartenstein Johannes, Kneen Clare Octavia, Horwell David Christopher, Bryans Justin Stephen: Nouveaux aminoacides cycliques substitues utilises comme agents pharmaceutiques, Novel substituted cyclic amino acids as pharmaceutical agents. Warner Lambert Company, Warner Lambert Company, MACRAE & CO, September 18, 1997: CA2244912 (5 worldwide citation)

Novel substituted cyclic amino acids of formula (I) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, and neuropathological disorders. Processes for the preparation an ...